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Maladaptation of cardiac and skeletal muscle in chronic disease : effects of exercise
(University of Missouri--Columbia, 2007)
The human genome is adapted for daily physical activity (85). Thus, a sedentary lifestyle is capable of promoting detrimental consequences to human health. The linkage between lack of sufficient physical activity and the ...
Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine
(University of Missouri--Columbia, 2007)
distinct, mechanisms. The aims of this dissertation addressed the hypothesis that H₂S elicits a preconditioning stimulus and protects against I/R injury through an eNOS-/p38 MAPK-/K channel-/HO-1 dependent mechanism....
The effects of physical activity on adipose tissue metabolism and DNA methylation
(University of Missouri--Columbia, 2009)
The increased prevalence of obesity and diabetes threatens both the real and economic health of Western counties. There were two major goals of this dissertation, 1) to determine if in response to inactivity and hyperphagia ...
Metabolic and functional consequences of adenylate kinase deficiency in skeletal muscle
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The primary function of skeletal muscle is to generate tension, and this ultimately occurs through ATP utilization. An increase in ADP and a depression ...
Molecular mechanisms of tumor invasion in three-dimensional collagen matrices
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cancer remains a significant cause of morbidity and mortality worldwide, and invasion and metastasis substantially contribute to poor prognosis and ...