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Reactivity of lesions derived from abasic (AP) sites in DNA
(University of Missouri--Columbia, 2021)
DNA is vital to cellular function. Therefore, maintaining the integrity of the structure of DNA is of the utmost importance. Damage to the DNA is unavoidable and can be detrimental to organisms. Abasic (Ap) sites are the ...
Radiotracers for examining biological functions of plants and microbes
(University of Missouri--Columbia, 2021)
Tracers are used for qualitative and quantitative investigation of a system. Radiotracers have a radionuclide to observe chemical or biological processes by detection of the radionuclide's decay energy. They are non-disruptive ...
Structural and kinetic studies of human aldh7a1 and aldh9a1
(University of Missouri--Columbia, 2021)
The regulation and detoxification of endogenously and exogenously derived aldehydes is paramount to cellular survival due to the highly reactive nature of aldehydes as electrophiles. Human aldehyde dehydrogenases (ALDHs) ...
An evaluation of the need for critically refined purification procedures in fluorescent carbon dot syntheses : the ramifications of the ubiquitous presence of reaction by-products on quenchometric and light harvesting applications
(University of Missouri--Columbia, 2021)
Fluorescent carbon dots constitute a novel and intriguing class of nanocarbons that display unique optical properties and can be purportedly generated from virtually any carbon-containing source. For example, the thermal ...
Probing synthesis of L-ascorbic acid in Arabidopsis thaliana genotypes
(University of Missouri--Columbia, 2021)
L-Ascorbic acid (L-AsA), also known as vitamin C, is a crucial vitamin for both plants and animals due to its antioxidant properties and abilities to scavenge harmful reactive oxygen species (ROS). However, some animals ...
Acrylate synthesis from carbon dioxide - ethylene coupling catalyzed by first-row transition metal complexes
(University of Missouri--Columbia, 2021)
Carbon dioxide (CO2) is an abundant and renewable carbon source than can be used as feedstock for the synthesis of value-added materials. One such material is acrylic acid, and acrylate derivatives, which can be used in ...
Lipid vesicle fusion as a vehicle to study transmembrane protein interactions
(University of Missouri--Columbia, 2021)
Alzheimer's disease, among other neurologically degenerative diseases, has been linked to protein-enzyme interactions that originate within the transmembrane domain of a cell. The lipid environment that houses these ...
The adsorption of environmental pollutants in gas and aqueous media utilizing nano-scale materials
(University of Missouri--Columbia, 2021)
In this body of work, the synthesis and characterization of several nanoporous materials have been described, as well as the application of these materials towards environmentally positive means. Largely, this work involves ...
Near infrared fluorescent sensors for selective glucose recognition
(University of Missouri--Columbia, 2021)
With diabetes becoming a major health concern worldwide, it is growing clear that novel technologies are needed to monitor blood glucose in a manner that is continuous, real-time, and long-term --all while alleviating the ...
Lc-ms/ms method development for quantitation of nicotine in toenails as a biomaker for secondhand smoke and standard lipoprotein mimetic models
(University of Missouri--Columbia, 2021)
Passive smoke or (secondhand smoke) is defined as when a non-smoker is unintentionally exposed to a smoking environment from cigarettes, cigars, or pipes. Passive smoke can result in adverse health effects leading to heart ...
Synthesis, characterization, and reactivity of actinide complexes bearing An-E bonds (An = Th, U; E = P, As)
(University of Missouri--Columbia, 2021)
Organoactinide complexes bearing An-E (An = Th, U; E = P, As) bonds were synthesized and reactivity studies were performed with various unsaturated and industrially/environmentally relevant small molecules in an effort to ...
LC-MS/MS method development for quantitative analysis of cyanogenic glycosides in elderberry and lipid peroxidation products in mice
(University of Missouri--Columbia, 2021)
Cyanogenic glycosides (CNGs) are naturally occurring plant molecules (nitrogenous plant secondary metabolites) which consist of an aglycone and a sugar moiety. Hydrogen cyanide (HCN) is released from these compounds following ...
Synthesis and characterization of pn monoanionic ligands and their reactivity with actinides
(University of Missouri--Columbia, 2021)
Organoactinide complexes have gained much popularity in the recent decades particularly in the field of nuclear waste sequestration. With the increase of nuclear power along side other residual nuclear waste from power ...
Polyionic nanoclays as tailorable hybrid organic-inorganic platforms
(University of Missouri--Columbia, 2021)
We disclose the synthesis, characterization, and application of an imidazolium-based hybrid inorganic-organic layered magnesium phyllo(organo)silicate nanosheets, coined polyionic nanoclays (PINCs), as an emergent class ...
Synthesis and spectroelectrochemical study of novel polyhedral borane derivatives
(University of Missouri--Columbia, 2021)
The substitution chemistry of dodecahydro-closo-dodecaborate (2-) and decahydro-closodecaborate (2-) as well as the spectroelectrochemical properties of the resulted compounds which we refer to herein as "polyaryl boranes" ...