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Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
(University of Missouri--Kansas City, 2012)
Alcohol abuse is known to induce liver diseases and neurodegeneration. Chronic alcohol use during medication is known to decrease drug efficacy and increase toxicity. In addition, alcohol is known to interact with other ...
Docosahexaenoic acid and lipid peroxidation products : insights from studies with microglial cells and mouse brain
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Oxidative stress is known to play an important role in neurodegenerative diseases. Microglia are the primary innate immune cells in the central nervous ...
A Paradoxical Reality: The Blessings and Burdens of the African American Female Educational Leader
(University of Missouri -- Kansas City, 2018)
The African-American female educational leadership experience is an interesting and
unique journey toward personal and professional achievement. This journey proves to be
quite precarious in that it is not unusual for ...
End-tidal carbon dioxide in the diagnosis of acute pulmonary embolism in hospitalized adult patients
(University of Missouri--Columbia, 2018)
Pulmonary embolism (PE) causes 100,000 deaths and contributes to over 4 billion dollars of annual healthcare costs. Acute PE is a diagnostic challenge as symptoms vary widely and are often nonspecific. Definitive diagnosis ...
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop a protein-based siRNA
nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently
discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...
Solar adoption in the rural Midwest : the diffusion of solar photovoltaic technology in two Midwestern states
(University of Missouri--Columbia, 2018)
In a nation of diverse geographies, many regions across the United States' vast rural landscapes have expressed support for the current administration's policies. At the same time, these rural areas have displayed a slow ...
Pictorial representations of monkeys and simianesque creatures in Greek art
(University of Missouri--Columbia, 2018)
"Primates are visually disturbing to many--at least I thought so when I was young. Their physical and behavioral similarities with humans were uncomfortable and jarring to my developing mind. As an adult, however, I have ...
A projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarii is critical for cardiorespiratory responses to hypoxia
(University of Missouri--Columbia, 2019)
The arterial chemoreflex is an essential protective mechanism for adaptive responses to hypoxia. Stimulation of peripheral chemoreceptors initiates a reflex response that generates compensatory physiological responses, ...