Search
Now showing items 1-20 of 30
Cyclotron produced nuclides for PET imaging and radiotracer studies
(University of Missouri--Columbia, 2015)
Sucrose was labeled at three different positions with radioactive fluorine, F-18, and applied to corn plants to study the transport of sugar in maize and to better understand the basic transport mechanism. The transport ...
ICP-MS analysis of fission product diffusion in graphite for high-temperature gas-cooled reactors
(University of Missouri--Columbia, 2015)
High-temperature gas-cooled reactors (HTGRs) are one of the candidates being considered for the replacement of current nuclear reactor designs. Diffusion coefficients for fission products in HTGR graphite are required for ...
Structural and functional studies of proline catabolic enzymes and human aldehyde dehydrogenases
(University of Missouri--Columbia, 2015)
Oxidation of amino acids, like proline catabolism, is a central part of energy metabolism. Proline is oxidized to glutamate by two enzymes: proline dehydrogenase (PRODH) and 1-pyrroline-5-carboxylate dehydrogenase (P5CDH). ...
Chlorine and singlet oxygen photoelimination from organoplatinum(IV) complexes
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Solar energy is the most promising carbon neutral energy source for the future. Splitting of simple molecules like HX (X = Cl, Br) has become an ...
Kinetics and mechanisms associated with redox regulation of protein tyrosine phosphatase 1B (PTP1B)
(University of Missouri--Columbia, 2015)
Here, we report on the kinetics and mechanisms associated with redox regulation of the protein tyrosine phosphatase PTP1B. We determined rates of thiol- and phosphinemediated recovery of catalytic activity from the ...
Characterization of acyclic rhodium tetrathioether ligans systems for 105Rh(III)
(University of Missouri--Columbia, 2015)
Rhodium-105 is a 36 hr half-life beta emitter potentially useful for radiotherapy. Previously, the reaction of 105 Rh-cholride with a linear tetrathioether ligand resulted in several species. Evaluation of this reaction ...
Investigating Technetium-99m/Rhenium(V)-Cyclized Octreotide analogues using experimental and computational methods
(University of Missouri--Columbia, 2015)
Radiolabeled peptides have been of long-standing interest as cancer imaging and radiotherapy agents. Two radioactive isotopes of rhenium are potentially useful for peptide-targeted radiotherapy. Re-186 has a half-life of ...
Spectroscopic distinguishability, forced degradation kinetics and lc-ms/ms degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns
(University of Missouri--Columbia, 2015)
5-Fluorouracil (5-FU) is a commonly used antiviral and anticancer drug. 5-FU is believed to exist in various tautomeric forms, which are believed to contribute to 5-FU's cytotoxicity. In order to understand the activity ...
Fluorine-18 capture by substituted BODIPY derivatives
(University of Missouri--Columbia, 2015)
For the medical community to effectively decrease the number of deaths caused by cancer each year, we must develop tools that allow for the early detection of biological abnormalities. Earlier detection is key to increasing ...
Arsenic for potential diagnostic imaging and radiotherapy
(University of Missouri--Columbia, 2015)
Targeted agents hold promise for non-invasive in vivo imaging, therapy, and monitoring of diseases. Foundational work focused on imaging and therapy of cancer has centered primarily on the use of 18F, 90Y, 99mTc, and 131I ...
Chemistry dissertation (not yet available)
(University of Missouri--Columbia, 2015)
Energy transfer and gas diffusion at gas-liquid interfaces
(University of Missouri--Columbia, 2015)
The interactions of gasses and liquids play an important role in many systems in chemistry. Gas-liquid surface scattering techniques are a useful tool towards the investigation of energy transfer resulting from gas-liquid ...
Synthesis and reactivity of copper(i) amidinate complexes
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Group 11 transition metals are used daily throughout our bodies and as additives in many common products. One biological function of copper, a group ...
Nuclear forensic applications of uranium oxide chemistry and morphology
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The entire nuclear fuel cycle is a chemistry-intensive process, from accessing the raw materials from ore, to enriching and forming the fuels, to the ...
Synthesis and photochemistry of PT (IV) hydroxo complexes
(University of Missouri--Columbia, 2015)
Global energy consumption and the production of clean renewable energy have become greater challenges. Sunlight-induced splitting of water into H2 and O2 is one of the leading strategies to achieve clean and renewable ...
Radiochemical and analytical methods of analysis of radiological dispersal devices
(University of Missouri--Columbia, 2015)
The events on September 11th 2001 and subsequent attacks in America and around the world have brought a renewed interest in the nation's security including the concern over the use of a nuclear or a radiological dispersal ...
Synthesis of exo-affinity labeling agents of protein tyrosine phosphatase non-receptor type 1
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Protein-tyrosine phosphatase 1B (PTP1B) is a negative regulator in the insulin signaling cascade. A lot of research has focused on inhibiting PTP1B ...
Computational studies of five macromolecular systems
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] C-alkylpyrogallol[4]arenes have been studied by DFT computations and the results compared to experimental observations. Local minima of different ...
On the kinetics and mechanisms associated with covalent inactivation of protein tyrosine phosphatase 1b (ptp1b) by dietary phytochemicals and affinity labeling molecules
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Phytochemical are compounds that occur naturally in plants. These compounds are what give many foods their distinct color and flavor. There are five ...
Strategies for the attachment of organic functional groups to silicon surfaces and measurement of vapor pressure of ionic liquids
(University of Missouri--Columbia, 2015)
Surface modifications of silicon surfaces have been studied for several decades. There are several approaches for attaching organic molecules with specific functionalities to these surfaces, utilizing both the selectivity ...