Search
Now showing items 1-20 of 31
Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
(University of Missouri -- Kansas City, 2018)
Acetaminophen (APAP) is a commonly used analgesic responsible for over 56,000
overdose-related emergency room visits annually. A long asymptomatic period and limited
treatment options result in a high rate of liver ...
Management, and Health Status Outcomes Of Obese Patients With Symptomatic Peripheral Artery Disease: Insight From The Portrait Registry
(University of Missouri -- Kansas City, 2018)
Obesity is present in 36.2%, 20.4 % and 29.0% of adults in the US, Netherlands and
Australia respectively. Obesity is a risk factor for cardiovascular disease and related
complications. The management and health status ...
Use of National Electronic Health Record (EHR) Data Warehouse to Identify Inappropriate HbA1c Orders for Sickle cell Disease Patients
(University of Missouri--Kansas City, 2018)
The glycated Hemoglobin (HbA1c) test is one of the most important diagnostic
and prognostic strategies for monitoring diabetes. However, the clinical utility of this test
is questionable for sickle cell disease patients, ...
Effect of Angina Under-recognition on Treatment Escalation in Outpatients with Stable Ischemic Heart Disease
(University of Missouri--Kansas City, 2017)
Almost a third of outpatients with chronic coronary artery disease (CAD) report
having angina in the prior month, which is frequently under-recognized by their
cardiologists. Whether under-recognition is associated ...
Decisional Conflict in Peripheral Arterial Disease: Association with Treatment Choice and Health Status
(University of Missouri--Kansas City, 2017)
Background: Symptom relief in peripheral arterial disease (PAD) can be obtained by
invasive options such as endovascular stenting as well as exercise, and PAD medications.
Each of these options have their own risks and ...
Menstruation and Contraception Patterns of Female Adolescent Transplant Patients
(University of Missouri--Kansas City, 2017)
BACKGROUND
New data and guidelines support the use of contraception in adolescents on immunosuppressants, however, there is no data regarding base knowledge and attitude toward contraception in this particular patient ...
Longer Right Colon Withdrawal Time and Retroflexion Duration Significantly Increases Adenoma Detection Rate: A Randomized Controlled Trial at Three Endoscopy Centers
(University of Missouri--Kansas City, 2018)
Purpose
Detection of adenomas is the foundation of colorectal cancer screening utilizing
screening colonoscopies. Adenoma detection rate (ADR) is an increasingly utilized core
quality measure for colonoscopies. ...
Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis
(University of Missouri--Kansas City, 2017)
Purpose/Objectives
Orbital cellulitis is an infection of the orbit that can lead to rare, but life-altering
complications. Previous studies have suggested that corticosteroids may improve recovery in
patients with ...
Are Functional Limitations Predictive of Use of Complementary and Alternative Medicine by Chronic Pain Patients?
(University of Missouri--Kansas City, 2017)
Chronic pain is an escalating problem in the United States, with a prevalence
of over 100 million people at an annual cost of $560 – 635 billion per year in medical
costs and lost productivity. Some of the consequences ...
Comparison of Patient-Reported Angina with Provider Assigned Canadian Cardiovascular Society Angina Class Before and After Revascularization
(University of Missouri--Kansas City, 2016)
Background: The Canadian Cardiovascular Society (CCS) classification system for angina is a critical
determinant of revascularization appropriateness. A major limitation of CCS is that it rates
patients’ symptoms from ...
Risk of Expectant Management and Optimal Timing of Delivery in Low-risk Term Pregnancies: A Population-based Study
(University of Missouri -- Kansas City, 2018)
Introduction
The benefits of the current obstetric recommendation to avoid elective deliveries
before 39 weeks of gestation in pregnant women have been questioned by several authors.1
5 Multiple concerns such as ...
The Association of Socioeconomic Status with Mortality and Hospital Length of Stay in Patients with Parapneumonic Empyema
(University of Missouri -- Kansas City, 2018)
Background: Parapneumonic empyema is an uncommon but serious complication of
pneumonia. Anecdotal evidence suggests that the prevalence of empyema may be on the rise.
The aim of this study is to estimate the current ...
Health Status Implications for Comorbid Diabetes in Patients with Symptomatic Peripheral Artery Disease: Insights from the PORTRAIT Registry
(University of Missouri -- Kansas City, 2018)
Patients with peripheral artery disease (PAD) and coexisting diabetes mellitus (DM) have an increased rate of PAD progression and reduced walking performance as compared with non-diabetic PAD patients. It is unknown, ...
A genetic linkage map of the fungus phycomyces blakesleeanus for gene identification by map-based cloning
(University of Missouri--Kansas City, 2012)
The Mucoromycotina is one of the basal lineages in the fungi, all of which are poorly understood. Mucormycosis is a life threatening infection caused by fungi of the order Mucorales, the most common species of which is ...
Identification of novel coding single nucleotide polymorphisms associated with acute respiratory distress syndrome
(2014-07-28)
ARDS is a lung condition characterized by impaired gas exchange with systemic release of inflammatory mediators, causing inflammation, hypoxemia and multiple organ failure. Disease susceptibility and progression are poorly ...
A Qualitative investigation of patients' transitional states of engagement in HIV-related medical care
(2014-03-20)
This qualitative study was designed to investigate the factors related to engagement in HIV-related medical care and specifically periods that can be characterized as transitions in and out of care. Data were collected ...
A Comparison of ADRR Scores in Very Young, School-age, and Adolescent Children with Type 1 Diabetes Mellitus
(2014-09-30)
Glycemic variability (GV) in children is remarkably dissimilar to GV in adults,
and furthermore is unique to age-specific pediatric groups. The Average Daily Risk
Range score has been shown to be a good indicator of GV ...
The utility of umbilical artery doppler in preterm premature rupture of membranes
(2013)
Preterm premature rupture of membranes (PPROM) is a common complication of
pregnancy and occurs in up to a third of all preterm births. Currently, there is no way to
predict how long a patient will remain pregnant after ...
Bleeding Risk Following Percutaneous Intervention in Patients with Diabetes Prescribed Dual Anti Platelet Therapy
(2015-07-28)
Patients with diabetes (DM) experience higher rates of in-stent restenosis and
therefore greater benefit from drug eluting stent (DES) implant at the time of percutaneous
coronary intervention (PCI). DES stent implantation ...
Guideline-Directed Statin Therapy in Patients with New or Worsening Symptoms of Peripheral Artery Disease
(University of Missouri -- Kansas City, 2018)
Objective: The ACC/AHA cholesterol guidelines recommend patients with peripheral artery
disease (PAD) be treated with a moderate to high-intensity statin. The extent to which PAD
patients with new or worsening ...