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DNA interstrand crosslinks arising from DAN strand breaks at true abasic sites in duplex DNA
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic sites (apurinic/apyrimidinic sites, Ap sites) are one of the most common forms of lesions found in genomic DNA. For the past decade, Gates group ...
Boron quantitative analysis and imaging analysis in plants
(University of Missouri--Columbia, 2017)
Boron is a very important nutrient element in plants, and thus it plays a key role in the world's food supply. Both boron deficiency and boron toxicity will cause plants to decrease their crop yield or even cause plants ...
Anisotropic shock response of 1,3,5-Triamino-2,4,6-Trinitrobenzene (TATB)
(University of Missouri--Columbia, 2018)
All-atom molecular dynamics simulations were used to study shock wave loading in both oriented single crystals and two orientations with the presence of a grain boundary of the highly anisotropic triclinic molecular crystal ...
Crossed-beam chemical reaction dynamics probed with universal and state resolved ion imaging
(University of Missouri--Columbia, 2018)
The main goal of chemical reaction dynamics is to unravel the intimate motions of individual atoms during a chemical transformation. This information must generally be inferred from indirect macroscopic measurement. Very ...
Synthesis and properties of small molecules designed to covalently capture native and oxidized forms of protein tyrosine phosphatase 1B (PTP1B)
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Protein tyrosine phosphatase 1B (PTP1B) is a validated target for the treatment of type 2 diabetes and obesity. The discovery of selective inhibitors ...
Sustainable chemical approaches to two-dimensional nanosheets and mesoporous platforms and catalysts
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Green Chemistry, also called as Sustainable Chemistry, envisions minimum hazard to improve the efficiency and performance of materials while designing ...
Development of fluorescent sensors for the detection of hydrophobic amines and glycolipids
(University of Missouri--Columbia, 2017)
A novel fluorescent sensor was designed and synthesized to detect hydrophobic amines and was used to extract them from synthetically prepared vesicles. This sensor had a higher affinity for diamines than primary amines, ...
Structural basis of stability of human immunodeficiency virus type 1 (HIV-1) capsid
(University of Missouri--Columbia, 2017)
Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). Since its discovery in early 1980, many advances have been made in the prevention and management of HIV/AIDS. ...
In vitro characterization of metal-binding and glutathione-binding proteins and their potential use to study transition metal homeostasis in plants
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Protein purification is vital for the characterization of the function, structure, and interactions of a protein.(Berg et al. 2002) Before a specific ...
Coordination chemistry of actinides and fission products (lanthanides and molybdenum) with neutral or acidic phosphine oxide ligands
(University of Missouri--Columbia, 2017)
Reprocessing in the nuclear fuel cycle is becoming essential considering the increasing demands for energy world-wide and the role nuclear energy will have in the future. Reprocessing not only aids in prolonging the supply ...
LC-MS/MS method development for quantification of bioactive compounds in elderberry and garlic botanicals
(University of Missouri--Columbia, 2016)
Elderberry (Sambucus nigra spp.) juice contains a variety of polyphenols mostly anthocyanins. In order to understand the variation of polyphenol levels by genotype, various elderberry juice samples were analyzed for total ...
Synthesis and reactivity of actinide phosphorano-stabilized carbene and phosphido complexes
(University of Missouri--Columbia, 2018)
Nuclear power plants have been operated in the United States for over 60 years, generating over 800 terawatt-hours of energy per year. However, there is still no reliable process to recycle the spent nuclear fuel. This ...
Synthesis and photochemistry of PT (IV) hydroxo complexes
(University of Missouri--Columbia, 2015)
Global energy consumption and the production of clean renewable energy have become greater challenges. Sunlight-induced splitting of water into H2 and O2 is one of the leading strategies to achieve clean and renewable ...
Deep ultraviolet resonance Raman spectroscopy as a tool for biomolecule analysis
(University of Missouri--Columbia, 2017)
Cholesterol is a major component of membranes, reducing their fluidity at higher concentrations. The UV Raman vibrational mode of the carbon-carbon double bond in cholesterol occurs at 1675 cm-1 is strongly resonance ...
Economical synthesis of carbon nanoparticles
(University of Missouri--Columbia, 2016)
One of the core values of a capitalistic market is cost efficiency which is tried and true even in cursed with discovering and developing materials as inexpensive as possible. Now, this is for a multitude of reasons but ...
Mechanistic and computational studies of ferroin, simple organic acids, and bromine oxides : elucidating the complex electrochemical dance in an oscillating reaction
(University of Missouri--Columbia, 2016)
Before the year 1950, many chemists in their 'right mind' held the archaic belief that all chemical reactions proceed strictly from reactants to products, though some could be coaxed into reverse. What we now know colloquially ...
Gold-catalyzed generation of vinylthionium ions and the development of an organocatalytic, asymmetric (4+3)-cycloaddition reaction
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] An allylic benzoate ester was prepared and used as a progenitor of vinylthionium ions for (4+3)-cycloaddition reactions. The chemistry was limited to ...
The development of exo-affinity labeling agents, inactivators of protein tyrosine phosphatase 1B
(University of Missouri--Columbia, 2016)
The phosphorylation of a tyrosine substrate is one of the most crucial reactions that regulate numerous biological processes. The phosphorylation is controlled by protein tyrosine kinases (PTKs) and protein tyrosine ...
Fluorescent sensors for the detection of glucosamine and thiaminase
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Fluorescence chemical sensing is a highly important tool in science and industry with many applications in pharmaceutical screening, cell respiration, ...
Molecular dynamics simulations of the shock response of the energetic materials pentaerythritol tetranitrate and hexahydro-1,3,5-trinitro-1,3,5-s-triazine
(University of Missouri--Columbia, 2016)
Energetic materials are the key active ingredients in explosive formulations. Understanding the response of energetic materials is vital for the design of safe and reliable explosives. It is a challenge to experimentally ...