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Integrin adhesion response to chemical and mechanical stimulation
(University of Missouri--Columbia, 2017)
It is well recognized that arterial stiffness increases with aging and aging-related diseases, such as hypertension. The mechanisms for the increase in stiffness have been largely thought to be the result of changes in the ...
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)
T2DM is a chronic disease characterized by low-grade inflammation in adipose tissue. Recent investigations have shown that a variety of immune cells can accumulate in adipose tissue contributing to the development of chronic ...
Functional recovery of the microcirculation during skeletal muscle regeneration
(University of Missouri--Columbia, 2018)
Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during ...
Sodium-Glucose Cotransporter 2 Inhibitors regulate vascular cell function
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Vascular disease is the major cause of morbidity and mortality in diabetic patients. Although numerous factors contribute to the development of ...
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)
Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ...