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Investigation of the replacement of cysteine residues in DOTA-(Tyr³)-octreotate: synthesis, characterization and evaluation of biological activities
(University of Missouri--Columbia, 2006)
Modification of the peptide sequence of DOTA-Tyr³-octreotate is carried out by substituting the cysteine moieties with D-Cysteine, L-Penicillamine and D-Penicillamine in one or both positions to study the effect of this ...
Studies of natural products that reveal novel strategies for efficient modification of DNA
(University of Missouri--Columbia, 2006)
DNA is the central molecule in cells. The correct function of cells depends on the structure of DNA. DNA damaging natural products often show cytotoxic or mutagenic properties, which many times land them medicinal value ...
Applications of elemental analysis for archaeometric studies : analytical and statistical methods for understanding geochemical trends in ceramics, ochre and obsidian
(University of Missouri--Columbia, 2006)
Three areas are covered in this dissertation: elemental analysis of Caborn-Welborn ceramics, elemental analysis and geochemical characterization of ochres, and construction and implementation of a portable XRF instrument ...
Structural supramolecular constructs of spheres and tubes
(University of Missouri--Columbia, 2006)
This thesis examines four different molecular systems that are in part or substrates for larger structural motifs that resemble spheres or tubes. The first project used donut shaped cucurbituril and through functionalization ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Studies of the chemistry of Tröger's base, cyclopentadienones, and 2,1-benzothiazines
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The sequential alkylation of Tröger's base was developed for the synthesis of symmetric dialkylation analogs. The products from this reaction were ...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Superscript 105]RH has attractive nuclear and chemical properties to be investigated as a nuclide for development of potential radiopharmaceuticals. ...
Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In recent years a great deal of interest has been focused on the exposure to nitrous acid (HNO2), nitric oxide (NO) and other nitrosating species ...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an ...
Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Leinamycin is a structurally novel natural product isolated from the Streptomyces with potent antitumor and antibiotic activity. In a thiol rich ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...
Structural studies of acid phosphatases from pathogenic bacteria
(University of Missouri--Columbia, 2007)
Acid phosphatases are important, ubiquitous, and diverse group of enzymes that catalyze the transfer of phosphoryl from phosphomonoester to water forming inorganic phosphate and alcohol. These enzymes play critical roles ...
Evaluating the suitability of the human toenail as a biomonitor for manganese status: the one source cohort
(University of Missouri--Columbia, 2007)
Numerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the hypothesis that Mn intake is reflected in toenail ...
Investigation of K₀ NAA at MURR and investigation of the toenail as a biomonitor for Mg, Zn, Cu, Se and Hg
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chapter 1: The K[subscript 0] method of neutron activation analysis (INAA) requires a stable core and neutron flux parameterization. The stability of ...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Anisotropic organic materials are attracting increasing interesting for their highly electro-optic characteristics. We are especially interested in ...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Supramolecular chemists can be thought of as the architects of the nano-scale world. We are primary concerned with the design and construction of ...
Organo nickel and platinum chemistry at the edge of corannulene
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corannulene (C[subscript 20]H[subscript 10]), a polycyclic aromatic hydrocarbon (PAH) is a bowl shaped fullerene fragment. This work involves investigations ...
Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents
(University of Missouri--Columbia, 2008)
Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ...
High valent uranium dioxo and imido complexes : synthesis and structure
(University of Missouri--Columbia, 2008)
Early actinide elements have attracted considerable attention in recent years due to the need for rigorous advancements in spent nuclear fuel recycling and remediation technologies, and for their emerging versatility in ...
Copper (I) coordination networks synthesized with solid-solid reactions
(University of Missouri--Columbia, 2008)
The use of solid-solid reactions in the development of one-, two-, and three dimensional Cu(I) coordination networks are discussed. The solid-solid reactions were monitored by a variety of instrumental techniques to achieve ...