As part of our efforts toward clinical translation of GA-198AuNP, our studies are focused on therapeutic efficacy of nanoparticulate GA198AuNP agent in dogs with prostatic carcinoma. The overall goal is to gain clinical ...

Purpose: Recently, point mutations in surface-exposed tyrosine residues have been shown to increase AAV transduction significantly. We examined the efficacy of conventional AAV8 and next generation tyrosine-mutant AAV8 ...

Background: Obstructive sleep apnea (OSA) has been linked to many cardiovascular diseases. Recent studies have linked OSA, endothelial dysfunction, and elevated CRP. The link between OSA and venous thromboembolic events ...

Recent work in the lab has demonstrated the requirement of MT1-MMP in the generation of proteolytic spaces within collagen I matrices, which we have termed vascular guidance tunnels. These tunnels are formed as a consequence ...

Designing effective orthopaedic implants requires detailed knowledge of variation in human bone form. Incomplete characterization of this variation can result in implants - such as femoral intramedullary nails - that may ...

Numerous barriers to public health exist in low-income communities, including but not limited to the access and affordability of healthy foods; access and affordability of local exercise facilities; and safe, pedestrian-friendly ...

Background: Nationally, half of patients with chronic disease use the Internet, however little is known about what promotes or inhibits patient use of the Internet for health information. Methods: To learn more about why ...

Introduction: There is limited literature about hospice medical directors. As a required member of the hospice interdisciplinary team, their background, experience and role appears to be quite varied. The research questions ...

The project "Pedicle Screw Placement with Intraoperative EMG Monitoring" is a retrospective study that hopes to narrow the findings of previous studies done to find EMG threshold readings in milliamps that correlate to ...

The pediatric neck mass is a common finding which includes a wide differential diagnosis. Determining the etiology based off of clinical examination alone is often difficult due to the asymptomatic nature of most masses. ...

There is very little application of photodynamic therapy to pediatric brain tumors, thus it is important to explore the localization of the commonly used photosensitizer Photofrin in a novel cell line in vitro. To date ...

This research is a collaboration between Department of Oral Biology in the School of Dentistry at UMKC, Department of Chemistry in The College of Arts and Sciences at UMKC, Department of Chemistry at Missouri Science and ...

Authentic embryonic stem cells (ESC) have probably never been derived from the inner cell mass (ICM) of pig, despite over 25 years of effort. Recently, several groups, including ours, have reported derivation of induced ...

Blood supply to virtually all tissues depends on endothelial cells, which form the linings of blood vessels. Growth and formation of endothelial cells occurs in two ways. Vasculogenesis describes the initial proliferation ...

Tumor cells can undergo adaptation to the hypoxia environment created by rapid growth of tumor cells to persist growing. A main regulator of hypoxia induced gene expression is hypoxia-inducible factor (HIF), and HIF can ...

Background: Elevated blood glucose (BG) is associated with an adverse prognosis in acute myocardial infarction (AMI) patients. While guidelines recommend insulin therapy to lower markedly elevated BG in AMI patients, it ...

Development of efficacious receptor-targeting contrast agents is particularly important for early detection of prostate cancers. When using non-invasive magnetic resonance imaging (MRI) for molecular imaging, sensitivity ...

The temporomandibular joint (TMJ) is one of the most complex joints in the mammalian body. Major changes in diet during weaning and corresponding responses of connective tissues of the feeding apparatus are incompletely ...

OSCC is one of the top 10 causes of cancer deaths worldwide, with only a 50% 5-year survival rate, necessitating the discovery of novel biomarkers and therapeutic targets. Using cDNA microarray analyses, we identified ...

Introduction: Recent studies have suggested a link between low serum vitamin D levels and insulin resistance. Moreover, those who are overweight or obese tend to have a high prevalence of insufficient or fully deficient ...