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Nanostructures for Diagnostics and Delivery [abstract]
(2010)
Nanostructures are increasingly being recognized for their novel applications in biological systems including nanomedicine— the application of nanoscale technologies for diagnosis, treatment and prevention of diseases. ...
Creation of 'Super Avastin': A New Nanomedicine Approach for the Treatment of PXE and AMD [abstract]
(2010-02)
Nanomedicine is an emerging medical area that utilizes nanoparticles for the detection and treatment of diseases. The ubiquitous place of gold in Nanomedicine stems from its chemical ability to serve in an unoxidized state ...
Acid-sensing ion channels as a novel target for drug addiction [abstract]
(2010-03)
Improving the treatment and prevention of drug addiction is an important goal for modern medicine. Ion channels have recently become very attractive targets in the search of new pharmacotherapies. Extracellular proton ...
An Electro-magnetic cell stimulator [abstract]
(2010-03)
A device to stimulate bone and muscle cell growth and possibly for treatment of bone and muscle injuries is presented. The device, called EStim, generates electric and magnetic pulses at programmable intervals. This device ...
Clinical Translation of Nanopharmaceuticals for Cancer Therapy [abstract]
(2010-02)
The most recent study involving 77,000 North American men has shown that regular prostate specific antigen (PSA) screening did not provide accurate diagnosis of prostate cancer and therefore did not save lives of cancer ...
Translational Approach to Examine the Importance of Aerobic Fitness on Nonalcoholic Fatty Liver Disease [abstract]
(2010)
Low cardiorespiratory fitness, independent of physical activity levels, is the best predictor of early mortality and is linked to type 2 diabetes and CVD. In the absence of exercise training, it is believed that genetic ...
The use of the Nintendo Wii for balance and cognition as a trement modality in occupational therapy in persons with multiple sclerosis for increased independence in activities of daily living [abstract]
(2010-03)
Objective: Examine the effectiveness of the Nintendo Wii on balance and cognition deficits to increase independence in activities of daily living for an individual with MS. Design: ABA single subject experimental design ...
Targeting the guanylate cyclase c receptor with an agonist peptide from enterotoxegenic Y. Enterocolitica [abstract]
(2010-03)
Heat-stable enterotoxin peptides (ST's) are expressed by enterotoxigenic strains of bacteria in order to co-opt an endogenous ligand-receptor system that regulates fluid homeostasis within the gut. Bacteria such as E. coli, ...
Applications of Energetic Materials and Copper Oxide Nanorods for Decontamination [abstract]
(2010-03)
We demonstrate the potential of nanoenergetic coatings and CuO nanorods to decontaminate surfaces infected with bacteria. The methods of decontamination include (i) fast combustion of an energetic paint applied on contaminated ...
Investigation and Optimization of Silorane-Based Polymer System [abstract]
(2010-03)
This research is a collaboration between Department of Oral Biology in the School of Dentistry at UMKC, Department of Chemistry in The College of Arts and Sciences at UMKC, Department of Chemistry at Missouri Science and ...
Derivation and characterization of LIF and FGF2 dependent Porcine Induced Pluripotent Stem Cells [abstract]
(2010-02)
Authentic embryonic stem cells (ESC) have probably never been derived from the inner cell mass (ICM) of pig, despite over 25 years of effort. Recently, several groups, including ours, have reported derivation of induced ...
Development of an in vitro model of quail vasculogenesis [abstract]
(2010-02)
Blood supply to virtually all tissues depends on endothelial cells, which form the linings of blood vessels. Growth and formation of endothelial cells occurs in two ways. Vasculogenesis describes the initial proliferation ...
Estrogen receptor and estrogen related receptor may corporatley regulate hypoxic gene expression [abstract]
(2010-03)
Tumor cells can undergo adaptation to the hypoxia environment created by rapid growth of tumor cells to persist growing. A main regulator of hypoxia induced gene expression is hypoxia-inducible factor (HIF), and HIF can ...
Geographic distribution of Show Me Healthy Women providers and breast cancer incidence and mortality in Missouri counties [abstract]
(2010)
Breast cancer is the second most common cause of cancer death among US women. Regular mammography is the most effective method to reduce mortality. However, uninsured women face substantial barriers to receiving regular ...
Getting over a hangover : how do wake promoting neurons in the basal forebrain affect ethanol induced sleep? [abstract]
(2010)
Hangover is a common clinical manifestation of heavy alcohol use. Sleepiness/drowsiness is a common symptom of hangover; however its neuroanatomical substrate is unknown. The basal forebrain (BF) cholinergic neurons play ...
The experience of initiating and being on dialysis among the elderly [abstract]
(2010)
Chronic kidney disease (CKD) is a disease that requires extreme treatment measures to ensure survival for the patients it afflicts. These measures include dialysis and/or kidney transplantation. Since 1973, the federal ...
The impact of "July effect" on "failure to rescue" : do patients who undergo coronary artery bypass grafting at teaching hospitals face a selective disadvantage? [abstract]
(2010)
The new academic cycle in July is associated with the commencement of postgraduate medical education. Although this is presumed to be associated with poor patient outcomes, supportive evidence is limited for Cardiac surgery ...
Lectin affinity binding of pseudononas aeruginosa with polyacrylamide neoglycoconjugates [abstract]
(2010)
The main clinical feature of cystic fibrosis (CF) is a chronic progressive lung disease caused mainly by Pseudomonas aeruginosa (PA) infection. The mechanism of bacterial invasion is not very clear. It's been shown that ...
Coordinate regulation of GATA3 and CD4+ T-helper 2 (TH2) cytokine gene expression by the RNA-binding protein HuR [abstract]
(2010)
Asthma and other allergic inflammation diseases are major contributors to hospitalizations and deaths worldwide. These diseases are the result of over reactive immune responses initiating pro inflammatory mediators. These ...
Beta cell dysfunction, oxidative stress and S6K1 activation in pancreas in the Zucker obese rat model [abstract]
(2010)
Insulin resistance and beta cell dysfunction are leading components in the pathogenesis of type 2 diabetes mellitus. Over-nutrition leads to activation of the mTOR/S6K1. S6K1 activation leads to serine phosphorylation of ...