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Gene therapy in spinal muscular atrophy : RNA-based strategies to modulate the pre-mRNA splicing of survival motor neuron
(University of Missouri--Columbia, 2008)
Gene expression is the required process in eukaryotes in which DNA is transcribed into pre-mRNA, spliced to produce "mature" mRNA and translated into proteins. Inaccuracies in splicing events are receiving more attention ...
Protein processing strategies by adeno-associated virus type 5 (AAV5) and the effects of the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex on AAV protein stability
(University of Missouri--Columbia, 2008)
We report the initial identification of the ubiquitination of a parvovirus non-structural protein by the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex. The small Rep and capsid proteins of adeno-associated ...
Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae
(University of Missouri--Columbia, 2010)
GLC7 is an essential gene in Saccharomyces cerevisiae that encodes the catalytic subunit of protein phosphatase-1. Glc7 is conditionally activated by phospho-Glc8, which is phosphorylated by the cyclin dependent kinase, ...
Hormonal and genetic regulation of Helicobacter hepaticus-induced intestinal inflammation
(University of Missouri--Columbia, 2010)
Inflammatory Bowel Diseases (IBDs) affect millions of people worldwide and are characterized by a chronic intestinal inflammation resulting from a dysregulated immune response to environmental stimuli in genetically ...
Development of gene therapy for Duchenne muscular dystrophy heart disease in the MDX mouse model
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a fatal genetic muscle disease with no cure. DMD results from mutations in a critical muscle protein called ...
Exploring the cell surface : identification and characterization of lipoproteins in Mycoplasma mycoides subsp. mycoides large colony, Mycoplasma mycoides subsp. capri, and Mycoplasma capricolum subsp. capricolum
(University of Missouri--Columbia, 2009)
The Mycoplasma mycoides cluster is a group of genetically and antigenically related pathogenic bacteria that infect ruminants. The M. mycoides cluster members that are the focus of this discussion are three caprine pathogens: ...
Insights into understanding malaria parasite biology : characterization of the Plasmodium protein, MAL13P1.319
(University of Missouri--Columbia, 2011)
Malaria is responsible for approximately 250 million human infections and about a million deaths annually and is caused by the protozoan parasite Plasmodium, with P. falciparum the most pathogenic form of human malaria. ...
Identification and characterization of Boone Cardiovirus, a novel virus of laboratory rats
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cardioviruses are members of the Picornaviridae family capable of causing several forms of disease including myocarditis, encephalitis, diabetes, fetal ...
On the role of cytokines and route of antigen delivery on the modulation of experimental autoimmune encephalomyelitis
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Experimental autoimmune encephalomyelitis (EAE) is a mouse model of the human autoimmune disease multiple sclerosis and is caused by myelin-reactive T ...
Sequence and secondary structural analysis of a novel class of RNA aptamers that inhibit reverse transcriptase
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] RNA aptamers are synthetic RNAs selected for their ability to bind a molecular target. Reverse Transcriptase (RT) is the major target of antiretroviral ...
Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The germline specific RNA helicase GLH-1, a constitutive P-granule component, and DCR-1, the riboendonuclease responsible for processing small RNAs ...
Mechanisms of central and peripheral immune tolerance
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The decision of a stem cell to develop into the myeloid or lymphoid lineage has been postulated to occur in the bone marrow. However, a marker of ...
The role of apoptosis during inflammation resolution in Lyme arthritis
(University of Missouri--Columbia, 2019)
Experimental Lyme arthritis is induced by the infection of C3H mice with the spirochete, Borrelia burgdorferi, and is a valuable model to study the regulation of inflammation during bacterial infection. While the lab has ...
BTrCP is required for HIV-1 Vpu modulation of CD4, GaLV Env, and BST-2/Tetherin
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] The HIV-1 accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, ...
Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)
Coxiella burnetii is an obligate intracellular Gram-negative bacterial pathogen and the causative agent of human Q fever. This disease presents acutely as a flu-like illness, although it can escalate to a chronic and often ...
The influence of type II cytokines in central tolerance
(University of Missouri--Columbia, 2021)
While the genetic elements of many autoimmune conditions have been established, many environmental factors remain a mystery. Exposure to certain infections has been implicated as a possible explanation for the significantly ...
Inhibition and comprehensive analysis of hiv-1 vpu, examination of retroviral trafficking, and characterization of sars-cov-2 genetic material in wastewater
(University of Missouri--Columbia, 2021)
Both HIV-1 and SARS-CoV-2 have been responsible for millions of infectionrelated deaths. Despite advances in treatment for both viruses, neither has a cure, and those living with the disease can unknowingly spread the ...
Interactions between helicobacter-induced inflammation acute changes in the gut microbiota, and colorectal cancer in Smad3-/- mice
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, accounting for 551,269 deaths in 2018 alone. One ...
Investigating the deleterious role of B lymphocytes during brucella infection
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Brucellosis is a disease known for inducing chronic, often life-long, infections. While it is clear the host immune response fails to clear ...
Refinement of an established large-animal model to understand the tick-pathogen-host interface
(University of Missouri--Columbia, 2021)
Ticks are globally distributed vectors of important pathogens of human and animal health. Since the discovery of tick resistance in 1918, the field has sought continuously for the development of effective biologic control ...