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2,1-Benzothiazines : preparation and reactivity
(University of Missouri--Columbia, 2010)
The synthesis of chiral ligands to tune the reactivity and stereoselectivity of many catalytic asymmetric reactions has been given considerable attention in synthetic organic chemistry over the past decade. This report ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ...
Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty ...
Characterizing and understanding self-assembling, nanocapsule host-guest systems
(University of Missouri--Columbia, 2010)
Supramolecular, self-assembled nanocapsules have been shown to be capable of entrapping fluorescent guests. Previous solid- and solution-state research, focusing on hydrogen-bonded C-alkylpyrogallol[4]arenes (PgC6)nanocapsules, ...
Novel macrocyclic compounds as building blocks in supramolecular chemistry
(University of Missouri--Columbia, 2010)
Resorcinarenes and pyrogallolarenes have been widely used as building blocks for novel synthetic receptors and supramolecular self-assemblies. To explore new chemistry of these compounds, new substituted macrocyclic arenes ...
Development of a pH sensitive coumarin based chemosensor
(University of Missouri--Columbia, 2010)
Fluorescent probes have found several uses in monitoring the physiological state of cells. Recently, the Glass lab has developed a fluorescent sensor capable of binding norepinephrine in chromaffin cell vesicles. This ...
Radioanalytical multi-elemental analysis : new methodology and archaeometric applications
(University of Missouri--Columbia, 2010)
Several projects are covered in this dissertation: the application of instrumental neutron activation analysis (INAA) and rigorous statistical analyses to the sourcing of Egyptian limestone and Kenyan obsidian, and the ...
Development of long wavelength fluorescent sensors
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The design, synthesis and spectroscopic properties of several long wavelength/NIR fluorescent sensors are discussed. Amongst them, the metal ...
Synthesis of fluorescent 7-amino-2,1-benzothiazines and total synthesis of buddledone A
(University of Missouri--Columbia, 2011)
The development of new fluorescent compounds has been reported continuously due to their application as sensors and optical devices for material, biological and chemical applications. This dissertation reports the syntheses ...
Formal total synthesis of pseudopteroxale : progress toward total synthesis of hamigeran B
(University of Missouri--Columbia, 2011)
In the first chapter, a formal total synthesis of pseudopteroxazole is presented, highlightening an E-selective Horner-Emmons reaction, a Buchwald-Hartwig coupling, and a diastereoselective intramolecular Michael addition. ...
Structural basis of substrate recognition and inactivation in phosphatases
(University of Missouri--Columbia, 2011)
Phosphatases are ubiquitous enzymes that catalyze the transfer of phosphoryl group to water. In addition to being one of the most important and fundamental reactions in biological systems, phosphatases are critical to ...
Determination of trace elements levels in human plasma and radiated mice tongue by inductively coupled plasma-mass-spectrometry (ICP-MS)
(University of Missouri--Columbia, 2012)
An analytical method that uses a minimum150 μL of human plasma samples for the trace elements Fe, Cu, Zn, Mg and ultratrace elements Mn, Co, Cd, Pb was developed. The method was evaluated using both high resolution sector ...
Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)
Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ...
Discovery of small molecules that regulate the activity of protein tyrosine phosphatases
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes responsible for dephosphorylating phosphotyrosine residues through a phosphocysteine ...
Chemical mechanisms of DNA damaging natural products
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Natural products provide both novel molecular structures and new mechanisms that have significant therapeutical implications. The work described here ...
Tan A : a fluorogenic probe for thiaminase I activity
(University of Missouri--Columbia, 2012)
Vitamin B1 plays important role in cell metabolism. Deficiency of vitamin B1 can cause ailments in living organism, including EMS (Early Mortality Syndrom) in the predatory fish salmon in the Great Lakes. Deficiency of ...
Computational studies of three chemical systems
(University of Missouri--Columbia, 2011)
The subject of this dissertation is the use of electronic structure calculations to examine and supplement the experimental observations of three different chemical systems. Both ab initio and DFT methods have been employed. ...
Studies of the chemistry of sulfoximines, 2, 1 benzothiazines and cyclopentadienones
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The N-Acylation of a sulfoximine with carboxylic acids was accomplished with boric acid and several boronic acids. Aliphatic acids give fair yields ...
Measurement of trace element levels in noctuid larvae in response to baculovirus infections
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] While a number of studies have examined the effects of viral infections on the trace element status of mammals, very little is known about the roles ...
Alkene oxidation by platinum (II) oxo/hydroxo complexes
(University of Missouri--Columbia, 2011)
The facile reaction between tetranuclear Pt-oxo complex [(COD)4Pt4([mu]2-O)2Cl2]2[BF4]2 (1) and norbornene (NB) yields the stable platinaoxetane [(COD)2Pt2(OC7H10)Cl][BF4] (2) in quantitative yield. A rapid reaction between ...