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Analysis of interactions between the germline RNA helicases (GLHs) and their regulators KGB-1 and CSN-5 in Caenorhabditis elegans
(University of Missouri--Columbia, 2006)
, KGB-1, interacts with the GLH proteins, and the null kgb-1(um3) strain results in sterile worms at high temperatures; the germlines of these worms contain endomitotic replicating oocytes (EMO). We find that in kgb-1(um3) adults, while GLH-4 levels...
Viral envelope proteins and the HIV-1 accessory gene Vpu mediate selectivity of viral and host proteins in retroviral assembly
(University of Missouri--Columbia, 2012)
, where an HIV-1 accessory gene known as Vpu restricts the envelope protein from gibbon ape leukemia virus (GaLV Env) from assembling with HIV-1. Further studies from our lab demonstrated that Vpu recognizes GaLV Env in a manner almost identical to CD4...
Dicer interacts with the P-granule component GLH-1 : both localize to C. elegans nuclear pores and to stress-induced oocyte RNP granules
(University of Missouri--Columbia, 2010)
of GLH-1, are regulated by proteosomal degradation and are much increased when the Jun N-terminal kinase KGB-1 is missing in the kgb-1(um3) null. In the adult C. elegans germline DCR-1 is located throughout the cytoplasm as well as at the inner nuclear...
Serum resistance of an invasive nontypeable H. influenzae
(University of Missouri--Columbia, 2004)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Since the introduction of Haemophilus influenzae b polysaccharide-protein conjugate vaccines, the incidence of invasive H. influenzae disease dramatically decreased. Currently...
Microbial pathogen contamination in mouse gametes and embryos
(University of Missouri--Columbia, 2008)
Large numbers of transgenic and knockout mice have been generated. Cryopreservation provides an efficient and effective way to maintain these unique genetically modified rodent lines. However, there is a great risk of ...
An essential role in germline development for a P-granule associated novel protein in the model organism Caenorhabditis elegans and RNAi in the ubiquitous parasitic nematode Ascaris suum
(University of Missouri--Columbia, 2009)
The germline RNA helicases (GLHs) are constitutive components of P granules and important for fertility in C. elegans. Discovered as a GLH-1 partner, the P-granule associated novel protein (PAN-1) is important both in ...
Characterization of cellular pathways in spinal muscular atrophy
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is an autosomal recessive genetic disease, and is the leading genetic cause of death in infants. SMA is a severe neuromuscular disease...
Two aspects of peripheral immune tolerance : systemic and mucosal tolerance mechanisms
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune disease have not been...
Functional characterization of two putative mobile elements of the 'Mycoplasma mycoides cluster'
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Horizontal gene transfer has played a major role in bacterial evolution, including in the genus Mycoplasma, which is comprised of some of the simplest and smallest free...
Examination of neonatal immunity in IL-13 receptor alpha 1 deficient mice
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Recent work in our lab has demonstrated a role for interleukin-13 receptor alpha 1 (IL-13R[alpha]1) in the induction of apoptosis of T helper type 1 (Th1) cells in the neonatal...
Characterization of the role of adenovirus-5 (Ad-5) gene products E2A, E4ORF6 and VA RNA on adeno-associated virus type 5 (AAV5) transcription, translation and replication
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] AAV5 is the most distinct serotype of the AAVs differing from the prototype virus AAV2 at the nucleotide level. We show that in AAV5 the Rep transcripts terminate in the middle...