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Fully automated deep supervised and unsupervised learning approaches for 3D protein cryo-EM density map reconstruction
(University of Missouri--Columbia, 2019)
One of the most important components of the human body is the protein. Protein uses for building and repairing tissues, making enzymes and hormones. It is the essential building block of bones, muscles, cartilages, skin ...
Establishing a foundation for large DNA transfer to artificial minichromosomes and B insert platforms in maize
(University of Missouri--Columbia, 2019)
In plants, conventional genetic engineering methods limit the number of available traits that could potentially improve the quality of agriculture. Agrobacterium-mediated transformation and biolistic bombardment are tools ...
Modulation of HBV infection and replication by cell-derived factors
(University of Missouri--Columbia, 2019)
infection. For example, HBV chronic infection is responsible for most of the cases of hepatocellular carcinomas. HBV is a small DNA virus and considered the prototype of family Hepadnaviridae. HBV genome is composed of partially double-stranded, relaxed-circular...
Investigating pore-forming peptides using the atomic force microscope
(University of Missouri--Columbia, 2019)
In my projects, I used the Atomic Force Microscope (AFM) to image the effects of pore-forming peptides and I used the Focused Ion Beam (FIB) to modify AFM cantilevers to increase the precision of force spectroscopy ...
Insights into atomic orbital polarization in polyatomic dissociation from DC slide velocity map imaging
(University of Missouri--Columbia, 2019)
surface (PES) since they completely embody the forces between the constituent atoms. .. Photodissociation of small molecules has been studied using variety of detection methods, such as, photofragment translational spectroscopy, [4,5] Laser...
Machine learning methods for 3D object classification and segmentation
(University of Missouri--Columbia, 2018)
Object understanding is a fundamental problem in computer vision and it has been extensively researched in recent years thanks to the availability of powerful GPUs and labelled data, especially in the context of images. ...
Computational studies of three chemical systems
(University of Missouri--Columbia, 2011)
is the study of pyrogallol[4]arene with R-groups R=H and R=phenyl. This macrocycle self-assembles into dimeric and hexameric nanocapsules. Several different structures for the macrocycle and its subunits, their relative energies, and their solvent interactions...
4D printing of stimulus-responsive polymeric materials
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Rising beyond 3D printing techniques, 4D printing can fabricate complex structures with inks made of stimulus-responsive polymeric materials. Thus, after printed...
Performance tests on asphalt mixtures at multiple temperatures and development of pavement temperature maps
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Thermal cracking and rutting are deteriorations that significantly affect asphalt pavements in the United States (US). Thermal cracking is ...
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic substituents was investigated...
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)
Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic ...
The early imperial ceramics as evidence for life at Roman Sardis
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Historical testimonia tell us that in the year 17 CE, an earthquake struck in Western Asia Minor and destroyed the city of Sardis. Recent excavations ...
Air-side heat transfer enhancement by self-agitators
(University of Missouri--Columbia, 2019)
, the best overall performance was obtained with twelve-row CHSAs with a pitch of 12.5mm, which caused a 68% enhancement in thermal-hydraulic characteristic compared to the clean channel at the same Reynolds number....
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
for in vivo imaging of GRP receptor positive tumors. A series of peptides that differed in their C-terminal ends or 6th position amino acid, were synthesized and coupled to the chelate, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
-like nanostructures, respectively, when the IL employed involves a coordinated and non-coordinated IL anion, respectively. Next, Chapter 4 has focused on exploitation of a purposefully designed IL-inspired surfactant, acting dually as a reducing and stabilizing agent...
Investigating the role of arginine 21 in the structure and function of human [alpha]A-crystallin
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ...
Investigating the role of arginine 21 in the structure and function of human [alpha]a-crystallin
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ...
Reconstructing activity patterns in prehistoric Jomon people using long bone cross-sectional geometry
(University of Missouri--Columbia, 2010)
This thesis uses long bone diaphyseal morphology to test hypotheses regarding behavior and functional adaptation among Jomon period hunter-gatherers from the Yoshigo site in Japan. Cross-sectional properties of Jomon femora ...
The use of geomorphological and pedological soil characteristics to assess planar borrowing at a Mandan Indian village, North Dakota
(University of Missouri--Columbia, 2011)
The Double Ditch State Historic Site is situated in a loess landscape immediately east of the Missouri River near Bismarck, North Dakota. The site was occupied from ca AD 1450 to 1785 by Mandan Indians, Plains Villagers ...
Conservation and allocation of slope in gravity sanitary sewer design
(University of Missouri--Columbia, 2010)
Gravity sanitary sewers are traditionally designed in a relatively direct route from source to destination after considering property boundary/easement constraints and topographic features. A methodology is presented in ...