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Purification and characterization of A[beta] and probing the interactions between myricetin and A[beta] using various spectroscopic methods
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Worldwide, millions of people suffer from symptoms of memory loss and confusion associated with Alzheimer's disease (AD). Mounting evidence suggests ...
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
by replacing the left phenylpropyl group of SA4503 with an N-iodoallyl group yielded a sigma1 selective ligand (1h-7, E-IA-DM-PE-PIPZ) that had appropriate lipophilicity for penetrating the blood brain barrier in the CNS. The in vivo studies using...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
spherical multicomponent assemblies via the selfassembly approach. Chapter 2 will describe the formation of very large molecular capsules based upon the self-assembly of six macrocycles called the C-alkylpyrogallol[4]arenes. These molecular capsules are held...
Computational studies of three chemical systems
(University of Missouri--Columbia, 2011)
is the study of pyrogallol[4]arene with R-groups R=H and R=phenyl. This macrocycle self-assembles into dimeric and hexameric nanocapsules. Several different structures for the macrocycle and its subunits, their relative energies, and their solvent interactions...
Insights into atomic orbital polarization in polyatomic dissociation from DC slide velocity map imaging
(University of Missouri--Columbia, 2019)
surface (PES) since they completely embody the forces between the constituent atoms. .. Photodissociation of small molecules has been studied using variety of detection methods, such as, photofragment translational spectroscopy, [4,5] Laser...
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic substituents was investigated...
Studies of natural products that reveal novel strategies for efficient modification of DNA
(University of Missouri--Columbia, 2006)
novel molecular recognition features of the natural product azinomycin using similar tools (Chapter 4). We characterized novel, reversible chemical reactions of leinamycin (Chapter 3). Amongst these were reversible DNA-alkylation and reversible adduct...
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)
Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
to effectively reduce TcO[subscript 4][superscript -] - to TcO[subscript 2] with high capacity (867 mg Tc (VII) / g FeS) and fast kinetics. The TcO[subscript 4][superscript -] - -FeS reaction is a surface mediated reaction with pH dependence. The long...
Spectroscopic investigations of the beta-amyloid peptide
(University of Missouri--Columbia, 2008)
The focus of this project is two-fold: examining the native structures of three different fragments of the beta-amyloid (A[beta]) peptide, and attempting to overcome some of the difficulties encountered in such an examination. ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
for in vivo imaging of GRP receptor positive tumors. A series of peptides that differed in their C-terminal ends or 6th position amino acid, were synthesized and coupled to the chelate, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA...
High valent uranium dioxo and imido complexes : synthesis and structure
(University of Missouri--Columbia, 2008)
Early actinide elements have attracted considerable attention in recent years due to the need for rigorous advancements in spent nuclear fuel recycling and remediation technologies, and for their emerging versatility in ...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
-like nanostructures, respectively, when the IL employed involves a coordinated and non-coordinated IL anion, respectively. Next, Chapter 4 has focused on exploitation of a purposefully designed IL-inspired surfactant, acting dually as a reducing and stabilizing agent...
pH sensitive fluorescent sensors
(University of Missouri--Columbia, 2007)
and remain off (pH=5.5). When stimulated the cell will exocytose the sensor and at pH=7.4, the sensor will fluoresce. The synthesis of pH sensitive fluorescent chemosensors for amines and their properties is described....
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
on the benzotriazine-1-oxide substrates involving various 3-aryl, and 3-cyclopropyl boronic acid to build a series of TPZ analogues. In addition to this work, we prepared novel 3-cyclopropyl-1,2,4-benzotriazine 1,4- dioxide which damages DNA under bioreductive hypoxic...
Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents
(University of Missouri--Columbia, 2008)
Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ...
Biologically relevant chemistry of sulfur heterocycles : from redox regulation of PTP1B to the biological activity of s-deoxy leinamycin
(University of Missouri--Columbia, 2008)
Protein tyrosine phosphatase 1B (PTP1B) is an important member of protein tyrosine phosphatase (PTPs) family that shares a conserved catalytic cysteine thiol residue. PTP1B acts as a negative regulator of insulin mediated ...
Oxidative DNA damage by 1-hydroxyphenazine, virulence factor of Pseudomonas aeruginosa : towards a molecular understanding of the bacterial virulence factor 1-hydroxyphenazine
(University of Missouri--Columbia, 2008)
1-Hydroxyphenazine is a secondary metabolite and virulence factor of Pseudomonas aeruginosa. This organism colonizes the airways of the patients of cystic fibrosis and causes progressive destruction of the airways. It is ...
Anion and solvent influences on the self-assembly of copper(I) coordination solids
(University of Missouri--Columbia, 2005)
and the reaction conditions involved will be discussed. This presentation will be divided into four major sections. The first section covers an in-depth look at those structural variances found among the copper(I) coordination solids synthesized using 4,4...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ...