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Creation of 'Super Avastin': A New Nanomedicine Approach for the Treatment of PXE and AMD [abstract]
(2010-02)
Nanomedicine is an emerging medical area that utilizes nanoparticles for the detection and treatment of diseases. The ubiquitous place of gold in Nanomedicine stems from its chemical ability to serve in an unoxidized state ...
Towards the Biological Synthesis of fullerene molecules [abstract]
(2010)
This invention describes the synthesis of carbon fullerene molecules and nanotubes using biological or enzymatic means. Presently carbon nanotubes are synthesized by either chemical vapor deposition or by electrical discharge ...
Nanostructures for Diagnostics and Delivery [abstract]
(2010)
Nanostructures are increasingly being recognized for their novel applications in biological systems including nanomedicine— the application of nanoscale technologies for diagnosis, treatment and prevention of diseases. ...
Engineering Optimal Islets for Transplantation for Type 1 Diabetes [abstract]
(2010-03)
Islet transplantation offers an improvement in the quality of life for those suffering from type 1 diabetes. It is found that islet cells may die during or soon after transplantation. Studies in our lab have shown that small islets are superior...
Use of Aggregation Prediction in Protein Formulations for Excipient Design
(2010-03)
immune responses in patients. Excipients are additive molecules that are not therapeutically active, but can increase the stability of protein formulations. An ideal excipient binds with aggregation prone regions on the protein to limit interaction...
UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT) [abstract]
(2010-03)
, Medicine, Nursing, Biological Sciences, and Computing and Engineering that focus on dental and musculoskeletal health. The Center of Excellence integrates basic and clinical investigators into a powerful translational team to prevent and treat diseases...
Quantitative Profiling of S-Nitrosylated Proteins in Parkinson's Disease Paradigms for the Effects of Botanical Phenolics [abstract]
(2010-02)
A convergent feature for most aging-related neurological diseases, such as Parkinson's Disease (PD), is excessive generation of free radicals - reactive nitrogen and oxygen species, which can contribute to neuronal cell ...
Dangerous Drug Reactions on the S&A iPhone App [abstract]
(2010)
The S&A drug database for handhelds, sold to dermatologists for 8 years, was uploaded as a new iPhone application (app), February 2010. Our program notes all warnings at the several FDA levels: boxed warnings, bold warnings, warnings, and adverse...
Dose escalation safety study of Nanotax® in dogs [abstract]
(2010)
circulation. The circulating half life is short which may be a result of clearance by the reticuloendothelial system. Final postmortem evaluation will be performed to determine whether the drug has accumulated in any organ system. We will use data generated...
Mechanism-based Inhibitor of Matrix Metalloproteinase-9 Rescues Brain from Focal Cerebral Ischemia-induced Damage and Improve Neurological Outcomes in Mice [abstract]
(2010-02)
Stroke is the third leading cause of death in the US and the primary cause of long-term disability. Acute ischemic stroke, the most common form of stroke, is caused by clotting in the cerebral arteries leading to brain ...
A Novel Method to Monitor Sequential Displacement of Capped Ligands in Gold Nanoparticles [abstract]
(2010-02)
Nanochemistry of ligand displacement reactions has attracted much attention in recent years for the development of myriad of new gold nanomaterials. Gold nanoparticles have shown applications ranging from tumor imaging ...
A Comparative Study between Antibody and Peptide Conjugated Gold Nanoparticles for In Vivo Targeting of EGFR in Pancreatic Cancer Bearing Mice Models [abstract]
(2010-03)
Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States due to its severe aggressiveness and lethal malignancy. Epidermal Growth Factor Receptor (EGFR) is over expressed in more than 95% ...
Clinical Translation of Nanopharmaceuticals for Cancer Therapy [abstract]
(2010-02)
The most recent study involving 77,000 North American men has shown that regular prostate specific antigen (PSA) screening did not provide accurate diagnosis of prostate cancer and therefore did not save lives of cancer ...
Early Breast Cancer Detection Using Fluorescence Mediated Tomographic Imaging [abstract]
(2010)
Development of reliable technologies for early detection and screening of breast cancer is significant since the overall accuracy of traditional mammography remains low for diagnosis of benign and malignant lesions. In ...
Cytotoxic Oleanane-type Triterpenen Saponins with N-acetyl Sugar from Albizia inundata [abstract]
(2010)
Bioassay-guided fractionation of a CH2Cl2-MeOH extract of the aerial part of Albizia inundata , collected in Argentina, resulted in the isolation of two new oleanane-type triterpene saponins with N-acetyl sugar (1, 2) and ...
Skeletal Muscle - Bone Crosstalk Regulating Osteocyte Function [abstract]
(2010-03)
Osteocytes are thought to be the primary cell in bone that responds to mechanical loading and the traditional view is that skeletal muscle's role relative to bone is in the application of those loads. We have hypothesized ...
Temporal trends in the management of severe hyperglycemia among patients hospitalized with acute myocardial infarction [abstract]
(2010)
Background: Elevated blood glucose (BG) is associated with an adverse prognosis in acute myocardial infarction (AMI) patients. While guidelines recommend insulin therapy to lower markedly elevated BG in AMI patients, it ...
Cancer stem cells in malignant peripheral nerve sheath tumor: Biology and therapeutic ramifications [abstract]
(2010-03)
Although monoclonal in origin, most tumors appear to contain heterogeneous populations of cancer cells. One possible explanation of this tumor heterogeneity is that human tumors are not merely monoclonal expansions of a ...
Antitumor withanolides from Withania somnifera [abstract]
(2010)
Surgery, University of Kansas Medical Center, Kansas City, Kansas 66160
Withania somnifera L. Dunal (Solanaceae) is an Indian plant commonly known as “ashwagandha”. This traditional plant has been used in Ayurvedic medicine ...
Maternal exercise during pregnancy and the influences on cardiac autonomic control [abstract]
(2010)
Background: Our previous research found decreased fetal heart rate (fHR) and increased heart rate variability (HRV) as a result of regular maternal aerobic exercise. These results suggest exposure to exercise throughout ...