Cytotoxic Oleanane-type Triterpenen Saponins with N-acetyl Sugar from Albizia inundata [abstract]

Abstract

Bioassay-guided fractionation of a CH2Cl2-MeOH extract of the aerial part of Albizia inundata , collected in Argentina, resulted in the isolation of two new oleanane-type triterpene saponins with N-acetyl sugar (1, 2) and seven known saponins (3-9). Their structures were established on the basis of extensive 2D NMR (HSQC, COSY or DQF-COSY, TOCSY, HMBC), ESIMS and chemical methods. Saponins 1-4 showed cytotoxicity against the in JMAR, MDA 1986, UM-SCC-2 and JHU011 human head and neck squamous cells using the MTS assay.