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Novel macrocyclic compounds as building blocks in supramolecular chemistry
(University of Missouri--Columbia, 2010)
Resorcinarenes and pyrogallolarenes have been widely used as building blocks for novel synthetic receptors and supramolecular self-assemblies. To explore new chemistry of these compounds, new substituted macrocyclic arenes ...
Preparation of polymeric boron-containing nanoparticles by emulsion polymerization for application in boron neutron capture therapy (BNCT)
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Boron neutron capture therapy (BNCT) is based on the nuclear capture reaction of isotope [superscript 10]B irradiated by low energy thermal neutron ...
Development of a pH sensitive coumarin based chemosensor
(University of Missouri--Columbia, 2010)
Fluorescent probes have found several uses in monitoring the physiological state of cells. Recently, the Glass lab has developed a fluorescent sensor capable of binding norepinephrine in chromaffin cell vesicles. This ...
Radionuclide production for radioisotope micro-power source technologies
(University of Missouri--Columbia, 2008)
Radioisotope micro-power sources (RIMS) hold great promise for the development of small power sources for use in numerous applications, including micro electromechanical (MEMS) systems, due to the five orders of magnitude ...
Sixteen valence-electron species containing boron: structural diversity abounds
(University of Missouri--Columbia, 2005)
[B, C, F, H₂] and [B, N, O, H₂] have been investigated via high level ab initio calculations. Both cyclic and acyclic connectivities have been examined for the singlet state. Chemical intuition suggests a ketene-like ...
Structural studies of acid phosphatases from pathogenic bacteria
(University of Missouri--Columbia, 2007)
Acid phosphatases are important, ubiquitous, and diverse group of enzymes that catalyze the transfer of phosphoryl from phosphomonoester to water forming inorganic phosphate and alcohol. These enzymes play critical roles ...
Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)
Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ...
Characterizing and understanding self-assembling, nanocapsule host-guest systems
(University of Missouri--Columbia, 2010)
Supramolecular, self-assembled nanocapsules have been shown to be capable of entrapping fluorescent guests. Previous solid- and solution-state research, focusing on hydrogen-bonded C-alkylpyrogallol[4]arenes (PgC6)nanocapsules, ...
Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty ...
Spectroscopic investigations of dendritic polymers as molecular containers
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Previous research has shown the fluorescent probe phenol blue will associate with the dendritic polymers polypropyleneimine (PPI) and polyamidoamine ...
Oxidation & 1, 5-hydride shift of sulfoximine derivatives
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oxidation of N-alkyl and N-aryl sulfoximines and 1,5-hydride shift of S-alkenyl sulfoximines have been studied. Oxidation of N-alkyl sulfoximines using ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ...
Determination of trace elements levels in plasma from larvae in the course of baculoviral and bacterial infections by inductively coupled plasma-mass spectrometry (ICP-MS)
(University of Missouri--Columbia, 2009)
While a number of studies have examined the effect of infections on the trace elements status of mammals, not any similar study in insects are found. In this study, we used inductively coupled plasma-mass spectrometry ...
Variable-temperature [superscript 1]H-NMR and AB initio study of 5-amino-imidazole-4-carboxamide (AICA) : competing paths for amide-H scrambling
(University of Missouri--Columbia, 2008)
5(4)-aminoimidazole-4(5)-carboxamide (AICA and TAICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular. Biotic nucleobase synthesis has been studied ...
Core-based hyperbranched polyethyleneimine coating in capillary electrophoresis
(University of Missouri--Columbia, 2009)
In capillary electrophoresis (CE), chemical and dynamic modification of a fused silica surface can be used to control the electroosmotic flow (EOF), to minimize the interaction of analytes with the capillary surface and ...
Rhenium complexes with O, N, S ligands
(University of Missouri--Columbia, 2006)
The main focus of this thesis is the synthesis and characterization of nonradioactive rhenium complexes containing O, N, S ligands. Chapter 2 describes the rhenium labeling of four somatostatin analogues. Confirmation for ...
Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The novel molecular architecture of dendrimers facilitates use in many applications. Using the solvatochromic probe phenol blue, the first direct ...
pH sensitive fluorescent sensors
(University of Missouri--Columbia, 2007)
Pheochromocytoma is a cancer of the adrenal gland. Pheochromoocytomas produce a variety of catecholamines, including norepinephrine. The result is high blood pressure which is caused by the release of catecholamines into ...
Structure and synthesis of four supramolecular structures involving Cu(I) and 4,7-phenanthroline
(University of Missouri--Columbia, 2007)
The design and synthesis of supramolecular species with discrete geometric shapes has been an area of much interest and research in recent years. Three isolated species of square shaped molecules and one infinite network ...
Synthesis of silyloxyacrolein for [4+3] cycloaddition and preparation of carbonate closomer
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Followed by Funk's method, I synthesized silyloxyacroleins and used them as dienophiles to react with different dienes in [4+3] cycloaddition reaction. ...