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Now showing items 1-15 of 15
Lc-ms/ms method development for quantitation of nicotine in toenails as a biomaker for secondhand smoke and standard lipoprotein mimetic models
(University of Missouri--Columbia, 2021)
, lung cancer, and other major diseases. Smoke from active smokers has been extensively investigated by a number of researchers. These studies have examined methods for the analysis of nicotine and its metabolites. In contrast, the development of methods...
Insights into atomic orbital polarization in polyatomic dissociation from DC slide velocity map imaging
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "The field of chemical reaction dynamics is based upon understanding the details of elementary chemical reactions. It seeks to answer fundamental questions such as, what...
Spectroscopic studies of transmembrane helical peptides and LC-MS/MS method development and validation for PFAS quantitation
(University of Missouri--Columbia, 2022)
Water hydrogen bonding (H-bonding) to [alpha]-helical transmembrane (TM) peptides is fundamental to understanding the behavior and function of [alpha]-helical peptides, disease pathways, and the development of new drugs. ...
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
Tirapazamine (TPZ) is currently undergoing a variety of phase I, II, and III clinical trials for the treatment of various human cancers. TPZ derives its medicinal activity by inducing DNA damage in poorly oxygenated tumor ...
Oxidative DNA damage by 1-hydroxyphenazine, virulence factor of Pseudomonas aeruginosa : towards a molecular understanding of the bacterial virulence factor 1-hydroxyphenazine
(University of Missouri--Columbia, 2008)
1-Hydroxyphenazine is a secondary metabolite and virulence factor of Pseudomonas aeruginosa. This organism colonizes the airways of the patients of cystic fibrosis and causes progressive destruction of the airways. It is ...
Studies of natural products that reveal novel strategies for efficient modification of DNA
(University of Missouri--Columbia, 2006)
DNA is the central molecule in cells. The correct function of cells depends on the structure of DNA. DNA damaging natural products often show cytotoxic or mutagenic properties, which many times land them medicinal value ...
A study of bacterial cellulose confined ionic liquid and deep eutectic solvent gel materials
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Pollutants have become more prevalent in the air, water, and ground, necessitating the development of technologies that would help, limit, reverse, monitor, measure...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Over the past decades, the Green Chemistry and Sustainability concept has aroused researchers to denounce their traditional ways of thinking regarding chemical processes...
Investigation of the thermostability and activity of biomolecules in bio-friendly deep eutectic solvents
(University of Missouri--Columbia, 2023)
The solvent environment of a biomolecule is critical to its optimal performance in various scenarios, including biocatalysis, drug delivery, therapeutics, and biosensing. This dissertation mainly discusses the implementation ...
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family that has two subtypes: sigma1 and sigma2. Sigma1 receptors are involved in several physiological functions such as psychosis and depression. Sigma2 receptors are expressed in ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the applicability for each drug...
An evaluation of the need for critically refined purification procedures in fluorescent carbon dot syntheses : the ramifications of the ubiquitous presence of reaction by-products on quenchometric and light harvesting applications
(University of Missouri--Columbia, 2021)
Fluorescent carbon dots constitute a novel and intriguing class of nanocarbons that display unique optical properties and can be purportedly generated from virtually any carbon-containing source. For example, the thermal ...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating new radionuclides...
Anion and solvent influences on the self-assembly of copper(I) coordination solids
(University of Missouri--Columbia, 2005)
The investigation of solvent and anion influences on the self-assembly of copper(I) coordination solids are presented. As these extended solids vary in structural design as reactions conditions are varied, both those ...
High valent uranium dioxo and imido complexes : synthesis and structure
(University of Missouri--Columbia, 2008)
Early actinide elements have attracted considerable attention in recent years due to the need for rigorous advancements in spent nuclear fuel recycling and remediation technologies, and for their emerging versatility in ...