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Studies of the chemistry of Tröger's base, cyclopentadienones, and 2,1-benzothiazines
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The sequential alkylation of Tröger's base was developed for the synthesis of symmetric dialkylation analogs. The products from this reaction were ...
Study of the chemistry of 2,1-benzothiazines and toward the total synthesis of elisapterosin B
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Using enantiomerically pure benzothiazines as templates, enantiomerically pure cyclobutanes were prepared. Such compounds are potentially interesting ...
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)
Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic ...
pH sensitive fluorescent sensors
(University of Missouri--Columbia, 2007)
Pheochromocytoma is a cancer of the adrenal gland. Pheochromoocytomas produce a variety of catecholamines, including norepinephrine. The result is high blood pressure which is caused by the release of catecholamines into ...
Spectroscopic studies of transmembrane helical peptides and LC-MS/MS method development and validation for PFAS quantitation
(University of Missouri--Columbia, 2022)
Water hydrogen bonding (H-bonding) to [alpha]-helical transmembrane (TM) peptides is fundamental to understanding the behavior and function of [alpha]-helical peptides, disease pathways, and the development of new drugs. ...
Mixed quantum-classical simulations of intersystem crossing in the exit channel and vibrational adaptive sampling configuration interaction
(University of Missouri--Columbia, 2022)
A computational study using mixed quantum-classical surface hopping simulations was performed for the reaction of O(3P) with dimethylamine and trimethylamine. These reactions produce an OH radical and while the OH radical ...
Deantiaromatization as a driving force in an electrocyclization of cyclopentadienone and the total synthesis of 1-epi-esco-pseudopteroxazole
(University of Missouri--Columbia, 2007)
Deantiaromatization has been successfully demonstrated as a driving force in an electrocyclization of cyclopentadienones. The reaction was found to be general for a number of substrates and provides a unique way to access ...
Separation and identification of peptides by integrated multidimensional liquid chromatography-mass spectrometry (IMDLC-MS)
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Integrated multidimensional liquid chromatography (IMDLC) is an innovative method used for separation of tryptic peptides. In this method a two-component ...
Ammonia elimination from protonated nucleobases
(University of Missouri--Columbia, 2007)
The dediazoniations of the diazonium ion 1 of 4-aminopyrimidine and of the tautomeric cytosinediazonium ions 2 and 3 are facile and result in the formations of cations 4, 5, and 6. The pyrimidine ring-opening of 4, 5 and ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
to effectively reduce TcO[subscript 4][superscript -] - to TcO[subscript 2] with high capacity (867 mg Tc (VII) / g FeS) and fast kinetics. The TcO[subscript 4][superscript -] - -FeS reaction is a surface mediated reaction with pH dependence. The long...
Advancing Uranium(III) reductive chemistry through hetroleptic metallocene aryloxide ligand frameworks
(University of Missouri--Columbia, 2023)
This dissertation looks at the reductive chemistry of Uranium (III)bis- pentamethylcyclopentadienyl arylox-ide complexes. For chapter two, the reactivity of two metallocene aryloxide U(III) complexes, [(C5Me5)2U(O-Ar)], R ...
Investigation of the thermostability and activity of biomolecules in bio-friendly deep eutectic solvents
(University of Missouri--Columbia, 2023)
The solvent environment of a biomolecule is critical to its optimal performance in various scenarios, including biocatalysis, drug delivery, therapeutics, and biosensing. This dissertation mainly discusses the implementation ...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Over the past decades, the Green Chemistry and Sustainability concept has aroused researchers to denounce their traditional ways of thinking regarding ...
Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
(University of Missouri--Columbia, 2019)
The overexpression of certain peptide receptors on cancers cells can be exploited for the development of radiopharmaceuticals that are selectively delivered to cancer cells for diagnostic imaging or therapeutic purposes. ...
Development of selective fluorescent sensors for detection of biologically relevant analytes
(University of Missouri--Columbia, 2023)
Fluorescent sensing has become an important tool in the detection and monitoring of biological materials. Specifically, fluorescent sensing has allowed us to make inroads into understanding the complex roles of proteins ...
Biomimetic reactions relevant to the study of abasic sites in DNA
(University of Missouri--Columbia, 2020)
Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While ...
Development of highly selective fluorescent sensors for detection of glycolipids in vesicles and visualization of glutamate for neuronal imaging
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Fluorescent sensors are very useful tools for exploring chemical biology and advanced medical research. Herein, we propose four different ...
Applications of elemental analysis for archaeometric studies : analytical and statistical methods for understanding geochemical trends in ceramics, ochre and obsidian
(University of Missouri--Columbia, 2006)
Three areas are covered in this dissertation: elemental analysis of Caborn-Welborn ceramics, elemental analysis and geochemical characterization of ochres, and construction and implementation of a portable XRF instrument ...
Phosphinimines as potential technetium environmental sensors
(University of Missouri--Columbia, 2007)
Phosphinimines, R₃P=NSiMe₃, undergo hydrolysis to form the phosphiniminiumcation, R₃P=NH₂+, which forms the ion pair [R₃P=NH₂+][X-] in the presence of an anion.Preliminary studies show that in the presence of TcO₄-, ...
2,1-Benzothiazines : preparation and reactivity
(University of Missouri--Columbia, 2010)
The synthesis of chiral ligands to tune the reactivity and stereoselectivity of many catalytic asymmetric reactions has been given considerable attention in synthetic organic chemistry over the past decade. This report ...