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Spatially resolved and bulk zinc analysis in biological samples of patients at different stages of Alzheimer's disease by high resolution inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2008)
-matched normal control (NC) subjects using HR-ICPMS. There are significant changes in zinc levels from subjects with MCI compared to subjects from NC group. The studies indicate that zinc homeostasis is altered early in the progression of AD and may play a role...
Evaluating the suitability of the human toenail as a biomonitor for manganese status: the one source cohort
(University of Missouri--Columbia, 2007)
in the status of Mn, a necessary trace nutrient which may also have toxic effects upon overexposure, stems from two recent developments: first, a greater awareness of the role of Mn-based enzymes in human health, and second, a renewed controversy over the use...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
-terminal vectors as a candidate of choice for specific in vivo targeting of the tumors overexpressing GRP-receptors. The positive outcome from this study may be the driving force for switching the focus to the development of the receptor targeting research using...
From carbon to copper : studies of novel nanomaterials
(University of Missouri--Columbia, 2007)
Nanomaterials are materials on the order of 10-9 m that are currently being investigated for use in a wide range of applications in the growing field of nanotechnology. This dissertation documents the synthesis, characterization, ...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Supramolecular chemists can be thought of as the architects of the nano-scale world. We are primary concerned with the design and construction of ...
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)
). Radioimmunoimaging and therapy commonly use antibodies (or antibody fragments) as targeting biomolecules, and may take a few days to accumulate in tumor cells. Thus they require radionuclides with longer half-lives. Arsenic-72 ([beta]+, 26 hour half-life) and 77As...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ...
Polyionic nanoclays as tailorable hybrid organic-inorganic platforms
(University of Missouri--Columbia, 2021)
We disclose the synthesis, characterization, and application of an imidazolium-based hybrid inorganic-organic layered magnesium phyllo(organo)silicate nanosheets, coined polyionic nanoclays (PINCs), as an emergent class ...
Measurement of radionuclides in biological tissues from occupationally exposed individuals
(University of Missouri--Columbia, 2022)
may provide information on the grade of the plutonium material an individual was exposed to. The measurement of radionuclides in brain tissue is of interest to the health physics community for developing internal dosimetry models. Examining...
The adsorption of environmental pollutants in gas and aqueous media utilizing nano-scale materials
(University of Missouri--Columbia, 2021)
In this body of work, the synthesis and characterization of several nanoporous materials have been described, as well as the application of these materials towards environmentally positive means. Largely, this work involves ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] Fluorescence sensing plays an important role in a wide variety of fields such as medical science, chemical biology, food industry and so on. Several new fluorescent probes were developed to target ...
Deantiaromatization as a driving force in an electrocyclization of cyclopentadienone and the total synthesis of 1-epi-esco-pseudopteroxazole
(University of Missouri--Columbia, 2007)
Deantiaromatization has been successfully demonstrated as a driving force in an electrocyclization of cyclopentadienones. The reaction was found to be general for a number of substrates and provides a unique way to access ...
Investigation of the replacement of cysteine residues in DOTA-(Tyr³)-octreotate: synthesis, characterization and evaluation of biological activities
(University of Missouri--Columbia, 2006)
Modification of the peptide sequence of DOTA-Tyr³-octreotate is carried out by substituting the cysteine moieties with D-Cysteine, L-Penicillamine and D-Penicillamine in one or both positions to study the effect of this ...
Computational studies of three chemical systems
(University of Missouri--Columbia, 2011)
The subject of this dissertation is the use of electronic structure calculations to examine and supplement the experimental observations of three different chemical systems. Both ab initio and DFT methods have been employed. ...
Palladium nanoparticles encapsulated with resveratrol-derived phenols and polyphenols for targeted prostate cancer therapy
(University of Missouri--Columbia, 2019)
of the Res-PdNP-4, intraperitoneal (IP) delivery and direct injection into the tumor may show a better response as has been the case with many different types of nanoparticles. In conclusion, the therapeutic efficacy results showed that Res-PdNP-4 have...
An evaluation of the need for critically refined purification procedures in fluorescent carbon dot syntheses : the ramifications of the ubiquitous presence of reaction by-products on quenchometric and light harvesting applications
(University of Missouri--Columbia, 2021)
Fluorescent carbon dots constitute a novel and intriguing class of nanocarbons that display unique optical properties and can be purportedly generated from virtually any carbon-containing source. For example, the thermal ...
Ab-initio and thermodynamic study of 123I-MIBG and 76Br-MBBG : choosing an effective tracer and theoretical study of the binding mechanism of 1-allyl 2-Thiourea as a functional monomer of Methyl Nitrate template
(University of Missouri--Columbia, 2023)
The study of mechanisms of reactions, how molecules bind, reaction energetics, and thermochemistry of chemical reactions is possible computationally. This is because computational methods are well able to help understand ...
Experimental and theoretical studies of CO2 capture from air and of crystalline, ferroelectric, non-linear optical materials
(University of Missouri--Columbia, 2022)
The combination of experimental and computational chemistry gives us a chance to explore organic materials with more breadth and depth. In this dissertation, we studied different organic materials with both experimental ...
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)
This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re( ...