Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2008 Dissertations (MU)
    • 2008 MU dissertations - Freely available online
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2008 Dissertations (MU)
    • 2008 MU dissertations - Freely available online
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Spatially resolved and bulk zinc analysis in biological samples of patients at different stages of Alzheimer's disease by high resolution inductively coupled plasma mass spectrometry

    Dong, Jiang, 1980-
    View/Open
    [PDF] public.pdf (2.040Kb)
    [PDF] short.pdf (12.79Kb)
    [PDF] research.pdf (1.027Mb)
    Date
    2008
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    One hypothesis that has gained considerable attention in the pathogenesis of Alzheimer's disease (AD) is trace element toxicity, and various elements, including zinc, have become the foci of renewed interest. The first study is analysis of spatially resolved zinc from senile plaques (SP) and neurofibrillary tangles (NFT) using laser ablation high resolution inductively coupled plasma mass spectrometer (LA-HR-ICPMS). By using matrix matched thin film standards, zinc was quantified in SP, NFT and adjacent neuropils in subjects with mild cognitive impairment (MCI). In addition, zinc was quantified in neuropils from age-matched normal control (NC) subjects. There are significant increases of zinc in MCI SP and MCI NFT compared to surrounding neuropils, suggesting a role of zinc in the pathogenesis of AD. The second study is bulk zinc analysis in human serum, cerebrospinal fluid (CSF) and brain tissues from subjects with mild cognitive impairment (MCI), early AD (EAD), late-stage AD (LAD) and age-matched normal control (NC) subjects using HR-ICPMS. There are significant changes in zinc levels from subjects with MCI compared to subjects from NC group. The studies indicate that zinc homeostasis is altered early in the progression of AD and may play a role in the pathogenesis of AD.
    URI
    https://hdl.handle.net/10355/6622
    https://doi.org/10.32469/10355/6622
    Degree
    Ph. D.
    Thesis Department
    Chemistry (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2008 MU dissertations - Freely available online
    • Chemistry electronic theses and dissertations (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems