Search
Now showing items 1-20 of 29
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and 1-phenylpropyl-4- benzylpiperazine...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
-terminal vectors as a candidate of choice for specific in vivo targeting of the tumors overexpressing GRP-receptors. The positive outcome from this study may be the driving force for switching the focus to the development of the receptor targeting research using...
Spectroscopic studies of transmembrane helical peptides and LC-MS/MS method development and validation for PFAS quantitation
(University of Missouri--Columbia, 2022)
of widespread contaminants in the ecosystem, which may cause adverse health effects under high levels of exposure. HPLC-MS/MS is commonly used for accurate and reproducible PFAS quantitation in water systems. Triple quadrupole and q-ToF mass analyzers...
Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty ...
Spatially resolved and bulk zinc analysis in biological samples of patients at different stages of Alzheimer's disease by high resolution inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2008)
-matched normal control (NC) subjects using HR-ICPMS. There are significant changes in zinc levels from subjects with MCI compared to subjects from NC group. The studies indicate that zinc homeostasis is altered early in the progression of AD and may play a role...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Molecular dynamics simulations of shock-induced pore collapse in single crystal [beta]-HMX
(University of Missouri--Columbia, 2023)
This thesis presents all-atom classical molecular dynamics (MD) simulations of shock-wave passage across a pore-type defect in single-crystal [beta]-1,3,5,7-tetranitro-1,3,5,7-tetraocane ([beta]-HMX). The purpose of this ...
Deantiaromatization as a driving force in an electrocyclization of cyclopentadienone and the total synthesis of 1-epi-esco-pseudopteroxazole
(University of Missouri--Columbia, 2007)
Deantiaromatization has been successfully demonstrated as a driving force in an electrocyclization of cyclopentadienones. The reaction was found to be general for a number of substrates and provides a unique way to access ...
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
series of known benzotriazine compounds, and have found a few with a moderate fluorescence quantum yield and molar extinction coefficient. Our novel effort toward hypoxia directed fluorescent small molecule probes may be useful for imaging in cancer...
Novel techniques for cold/ultracold molecular collisions
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This thesis presents the successful implementation of a slice velocity map imaging apparatus capable of performing molecular beam scattering experiments ...
Polyionic nanoclays as tailorable hybrid organic-inorganic platforms
(University of Missouri--Columbia, 2021)
We disclose the synthesis, characterization, and application of an imidazolium-based hybrid inorganic-organic layered magnesium phyllo(organo)silicate nanosheets, coined polyionic nanoclays (PINCs), as an emergent class ...
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] Fluorescence sensing plays an important role in a wide variety of fields such as medical science, chemical biology, food industry and so on. Several new fluorescent probes were developed to target ...
Investigation of the thermostability and activity of biomolecules in bio-friendly deep eutectic solvents
(University of Missouri--Columbia, 2023)
The solvent environment of a biomolecule is critical to its optimal performance in various scenarios, including biocatalysis, drug delivery, therapeutics, and biosensing. This dissertation mainly discusses the implementation ...
Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
. Early biological studies suggested that fasicularin's cytotoxic properties may stem from its ability to damage cellular DNA. Here in our laboratory, we have shown by sequencing gel studies that treatment of a 5'- [superscript 32]P-labeled DNA duplex...
Sustainable chemical approaches to two-dimensional nanosheets and mesoporous platforms and catalysts
(University of Missouri--Columbia, 2017)
, there is widespread recognition of the need to adopt cleaner, sustainable practices to enhance the quality and control of commercial products through a knowledge based approach. The goal for the researchers in sustainable chemistry is to meet the objective without...
Acrylate synthesis from carbon dioxide - ethylene coupling catalyzed by first-row transition metal complexes
(University of Missouri--Columbia, 2021)
family of low valent Fe complexes were found to facilitate CO2-ethylene coupling. However, the insertion of two CO2 units was observed, resulting in the formation of the dicarboxylate product methylmalonic acid (MMA). A one electron oxidation was found...
Radiotracers for examining biological functions of plants and microbes
(University of Missouri--Columbia, 2021)
Tracers are used for qualitative and quantitative investigation of a system. Radiotracers have a radionuclide to observe chemical or biological processes by detection of the radionuclide's decay energy. They are non-disruptive ...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Anisotropic organic materials are attracting increasing interesting for their highly electro-optic characteristics. We are especially interested in ...
2,1-Benzothiazines : preparation and reactivity
(University of Missouri--Columbia, 2010)
of efforts toward the syntheses of several families of enantiomerically pure 2,1-benzothiazine ligands. These ligands are unique in that they contain a chiral sulfoximine. Several 2,1-benzothiazine ligands were prepared in single one-pot syntheses and others...
Oxidative molecular layer deposition of redox-active thin-film polymers
(University of Missouri--Columbia, 2022)
Thin film materials research for a more sustainable future is growing rapidly and new techniques for depositing these films are beginning to surface. One such technique is highlight in this body of work using gaseous ...