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The effect of troponin I phosphorylation on the steepness of the Frank-Starling relationship
(University of Missouri--Columbia, 2013)
Heart failure begins with a reduction in the contractile strength of the cardiac myocytes (systolic dysfunction.) Cardiac myofibrils compensate via sympathetic activation to maintain adequate cardiac output. Beta-adrenergic ...
Myofibrillar regulatory mechanisms of stretch activation in mammalian striated muscle
(University of Missouri--Columbia, 2017)
Stretch activation is described as a delayed increase in force after an imposed stretch. This process is essential in the flight muscles of many insects and is also observed, to some degree, in mammalian striated muscles. ...
The contribution of titin to striated muscle shortening
(University of Missouri--Columbia, 2008)
Striated muscle shortens under various loads (i.e., performs work), which allows movement of the skeleton and pumping of blood throughout the circulatory system. The amount of work that a muscle can do is determined by the ...
Thick filament regulation of myocardial contraction
(University of Missouri--Columbia, 2006)
The ability of the heart to function as a pump is governed by mechanisms intrinsic to individual cardiac myocytes. The experiments in this dissertation were designed to examine the effects of sarcomere length and thick ...
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function
(University of Missouri--Columbia, 2005)
During times of low blood flow (ischemia), concentrations of wastes increase in tissues, which can lead to decreased striated muscle contractile function. Acute cardiac contractile dysfunction during ischemia is likely ...