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Deciphering of packing signal hypothesis in bacterophage RNA recognition by the MS2 capsid protein in virus assembly
(University of Missouri -- Kansas City, 2018)
MS2 is a classical example of a single-stranded RNA virus for which the genomic
RNA plays pivotal roles in the virus assembly process. Multiple dispersed RNA se
quence/structure motifs, packaging signals (PSs) varying ...
Evaluation of Cement-Based Reactive Media for Contaminant Remediation
(University of Missouri -- Kansas City, 2018)
Water contaminated with heavy metals, arsenic, and other industrial pollutants
poses a severe risk to human health. Reactive media present an opportunity to intercept
contaminants but have high material or environmental ...
Implementation of Solution and Solid Sate Nuclear Magnetic Resonance (NMR) Spectroscopic Techniques for Quantitative and Qualitative Analysis of Molecular Species
(University of Missouri -- Kansas City, 2019)
In this dissertation, spectroscopy has been used to solve a variety of problems in different
domains of science. Therefore, each chapter consists of different examples that have been
addressed using different concepts ...
Metals hosts in the Pennsylvanian Hushpuckney and Stark Black Shales from Selected Areas in Kansas City
(University of Missouri--Kansas City, 2017)
The Hushpuckney Shale of the Swope Formation and the Stark Shale of the Dennis
Formation, two black shales in the Pennsylvanian Kansas City group, contain elevated
concentrations of transition and based metal elements, ...
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)
Prostate cancer is the most common male malignancy and remains the second-leading
cause of death due to cancer in American men. While surgery and radiation are effective in
prostate cancer therapy at early stages, the ...
Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop various systems to deliver small
interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and
liver fibrosis. siRNAs targeting vascular endothelial ...
Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
(University of Missouri -- Kansas City, 2019)
Overall aim of this research project is to develop folic acid targeted nanomicelles
loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye.
Retinoblastoma and uveitis are diseases that ...
Evaluation of the Anti-Fibrotic Activity of PCBP2 siRNA in Primary Hepatic Stellate Cells and Discovery of Anti-PD-L1 Peptide and Nanobody for Immunotherapy
(University of Missouri -- Kansas City, 2018)
There are two major research objectives in this dissertation. Our laboratory
recently discovered a small interfering RNA (siRNA) that silences the poly (rC) binding
protein 2 (PCBP2) gene. It is hypothesized that silencing ...
Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
(University of Missouri--Kansas City, 2012-10-02)
Herpes simplex virus infections (HSV) in the eye are one of the leading causes of blindness across the world. Current available treatment options to treat HSV infections are solutions of trifluorothymidine (TFT), idoxuridine ...
Engineering of Human Acid Phosphatase Enzyme Sensitive Nanomedicine for HIV/AIDS Prevention by Topical Route
(University of Missouri -- Kansas City, 2018)
This study is divided into two aims. Aim #1 focuses on the development and
characterization of tenofovir (TFV) loaded a stimuli sensitive nanomedicine against male to
female HIV/AIDS infection. Aim #2 focus on the ...
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to present two approaches to identify Hepatic
Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and
systematic evolution of ligands by exponential ...
Performance standards for walk-in coolers and freezers in the United States as a function of local weather conditions
(University of Missouri--Kansas City, 2011-05-26)
Walk-in coolers and freezers are medium (~35º F) and low (~-10º F to -20º F)
temperature commercial food preservation equipment, with high market demand. There is
considerable potential for energy savings through ...
Effects of pressure and temperature on the yield strength of tantalum and rhenium
(2013)
The effects of pressure and temperature on the yield strength of tantalum and
the effects of pressure on the yield strength of rhenium were investigated using ruby
fluorescence. A new Raman system with a motorized stage ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
The objective of this dissertation is to present the various therapeutic approaches for two distinctly different diseases, prostate cancer and type-1 diabetes. Our objective (1) for prostate cancer is to evaluate the siRNA ...
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
(University of Missouri -- Kansas City, 2019)
Proteins are macromolecules involved in a diverse array of functions. Mutations or
abnormal levels of proteins are indicated in several diseases. Despite showing early
promise, the translation of protein therapeutics ...
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop a protein-based siRNA
nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently
discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...
Protein production and applications of NMR in pharmaceutical sciences
(2014-08-28)
The objective of Part I (Protein production for structural elucidation using NMR) is to design and develop strategies of producing amyloid beta protein for structural analysis using NMR. Amyloid beta oligomers are considered ...
Pressure-induced phase transitions in select molybdates and tungstates
(2013)
Mao-Bell and symmetric diamond anvil cells were used to study the effect of
high-pressure on a series of tungstate and molybdate compounds. The experimental
techniques of powder x-ray diffraction and Raman spectroscopy ...
Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
(University of Missouri--Kansas City, 2011-01-20)
HIV/AIDS has become one of the greatest threats to human health. Although inclusion of protease inhibitors (PIs) in HAART has greatly slowed the disease progression and improved the outcome of clinical treatment, the ...