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Synthesis and characterization of pn monoanionic ligands and their reactivity with actinides
(University of Missouri--Columbia, 2021)
-actinide complex reported has been with uranium as observed in 2018 by Schelter and Mindiola et al. With the introduction of the preliminary NP-Th complex comparisons between the two organoactinide complexes can be determined. In addition, a novel PN ligand...
Polyionic nanoclays as tailorable hybrid organic-inorganic platforms
(University of Missouri--Columbia, 2021)
, and the resulting heterogeneous catalysts are applied for the model reduction of 4-nitrophenol to 4-aminophenol to achieve the highest reaction turnover frequency yet reported in the literature (over 33,000 h-1 for nanoparticles comprising a 70:30 molar ratio of Au...
Lc-ms/ms method development for quantitation of nicotine in toenails as a biomaker for secondhand smoke and standard lipoprotein mimetic models
(University of Missouri--Columbia, 2021)
Passive smoke or (secondhand smoke) is defined as when a non-smoker is unintentionally exposed to a smoking environment from cigarettes, cigars, or pipes. Passive smoke can result in adverse health effects leading to heart ...
Acrylate synthesis from carbon dioxide - ethylene coupling catalyzed by first-row transition metal complexes
(University of Missouri--Columbia, 2021)
Carbon dioxide (CO2) is an abundant and renewable carbon source than can be used as feedstock for the synthesis of value-added materials. One such material is acrylic acid, and acrylate derivatives, which can be used in ...
Synthesis and characterization of cerium (III) and (IV) compounds
(University of Missouri--Columbia, 2022)
Treatment of Cp*2CeCl2K with various aryl alcohols and amines produces Cp*2Ce(O- 2,6-iPr2C6H3) and Cp*2Ce(N(C6H5)2). The crystallographic structures are presented as well as their fluorescence. Absorbance measurements ...
Measurement of radionuclides in biological tissues from occupationally exposed individuals
(University of Missouri--Columbia, 2022)
Keratinous materials have the potential to be used in criminal investigation of individuals who participate in nuclear smuggling or in the production of clandestine nuclear weapons. To develop the keratin biomonitor, its ...
Development of selective fluorescence neurosensor for neurotransmitter monitoring in live cells
(University of Missouri--Columbia, 2022)
detection. Over the last few years, various optical probes have been reported for neurotransmitters sensing, however, they usually suffer from lack of selectivity. In this work, we plan to develop a turn on fluorescence sensor based on coumarin-3- aldehyde...
LC-MS/MS method development for quantitative analysis of cyanogenic glycosides in elderberry and lipid peroxidation products in mice
(University of Missouri--Columbia, 2021)
Cyanogenic glycosides (CNGs) are naturally occurring plant molecules (nitrogenous plant secondary metabolites) which consist of an aglycone and a sugar moiety. Hydrogen cyanide (HCN) is released from these compounds following ...
Structural and kinetic studies of human aldh7a1 and aldh9a1
(University of Missouri--Columbia, 2021)
The regulation and detoxification of endogenously and exogenously derived aldehydes is paramount to cellular survival due to the highly reactive nature of aldehydes as electrophiles. Human aldehyde dehydrogenases (ALDHs) ...
The investigation of the self-assemblies of pyrogallol [4] arenes with large metal ions
(University of Missouri--Columbia, 2022)
Supramolecular chemistry involves the study of the non-covalent interactions between molecules. Host molecules such as C-pyrogallol[4]arenes form complexes via these supramolecular interactions. Pyrogallol[4]arenes are ...
Advancing Uranium(III) reductive chemistry through hetroleptic metallocene aryloxide ligand frameworks
(University of Missouri--Columbia, 2023)
This dissertation looks at the reductive chemistry of Uranium (III)bis- pentamethylcyclopentadienyl arylox-ide complexes. For chapter two, the reactivity of two metallocene aryloxide U(III) complexes, [(C5Me5)2U(O-Ar)], R ...
Biomimetic reactions relevant to the study of abasic sites in DNA
(University of Missouri--Columbia, 2020)
Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While ...
Self-assembly of functional metal-seamed pyrogallol[4]arene nanocapsules
(University of Missouri--Columbia, 2022)
C-alkylpyrogallol[4]arenes (PgCns, where n is the represents pendant alkyl chain lengths), bowl-shaped macrocycles, upon deprotonation, can self-assemble with metal ions into dimeric (M8L2) and hexameric (M24L6) metal-organic ...
Design and synthesis of group 8 transition metal complexes for C-C bond forming valorization of carbon dioxide
(University of Missouri--Columbia, 2023)
and CO2-C2H4 coupling. Several complexes have proven active for CO2 reduction, yielding value-added organic products such as oxalate, acrylate, propionic acid, and methylmalonic acid with divergent chemoselectivity of that reported for related iron...
Formation and properties of endogenous adducts and crosslinks generated by amine-catalyzed strand cleavage at an AP site in duplex DNA
(University of Missouri--Columbia, 2022)
Abasic sites in DNA are a very common lesion. They are formed spontaneously and in the presence of biological amines, enzymes, and proteins. If unrepaired, abasic sites lead to DNA strand breaks and crosslinks. This thesis ...
Development of selective fluorescent sensors for detection of biologically relevant analytes
(University of Missouri--Columbia, 2023)
Fluorescent sensing has become an important tool in the detection and monitoring of biological materials. Specifically, fluorescent sensing has allowed us to make inroads into understanding the complex roles of proteins ...
Ab-initio and thermodynamic study of 123I-MIBG and 76Br-MBBG : choosing an effective tracer and theoretical study of the binding mechanism of 1-allyl 2-Thiourea as a functional monomer of Methyl Nitrate template
(University of Missouri--Columbia, 2023)
The study of mechanisms of reactions, how molecules bind, reaction energetics, and thermochemistry of chemical reactions is possible computationally. This is because computational methods are well able to help understand ...
Synthesis and evaluation of modified NOTA chelators labeled with [99mTc]Tc/Re-tricarbonyl cores for potential theranostic agent development
(University of Missouri--Columbia, 2023)
To further optimize [99mTc]Tc/Re-tricarbonyl-NOTA complexes as potential theranostic agents, here we present the synthesis and evaluation of 1,4,7- triazacyclononane (TACN) chelators having different pendant arm functionalities. Briefly, we report...
Oxidative molecular layer deposition of redox-active thin-film polymers
(University of Missouri--Columbia, 2022)
. We identify the importance of a two-electron chemical oxidant with sufficient oxidation strength to oxidize both a surface and a gas-phase monomer to enable oMLD growth. The mechanistic insights we report will support rational molecular assembly of co...
A study of bacterial cellulose confined ionic liquid and deep eutectic solvent gel materials
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Pollutants have become more prevalent in the air, water, and ground, necessitating the development of technologies that would help, limit, ...