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Toward polar 1,4-diphenylbutadiene materials
(University of Missouri--Columbia, 2004)
The fast response time of [pi]-electrons makes organic materials increasing interesting as highly anisotropic materials. We are especially interested in dipole parallel-aligned crystals because of the much higher chromophore ...
Probing supramolecular assemblies via fluorescent reporter molecules
(University of Missouri--Columbia, 2007)
the organization of the capsule interior when fluorescent reporter molecules, (1-(9-anthryl)-3-(4-dimethylaniline) propane) and pyrene butyric acid, became entrapped. Solution state spectroscopic data, in agreement with solid state single crystal X...
Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents
(University of Missouri--Columbia, 2008)
Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ...
Ammonia elimination from protonated nucleobases
(University of Missouri--Columbia, 2007)
The dediazoniations of the diazonium ion 1 of 4-aminopyrimidine and of the tautomeric cytosinediazonium ions 2 and 3 are facile and result in the formations of cations 4, 5, and 6. The pyrimidine ring-opening of 4, 5 and ...
Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
formed by this compound in double stranded DNA. We report here that depurination of this N7-alkylguanine lesion is unusually facile. This is very relevant to its biological activity because an in vitro study done in a preclinical report shows...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
reported within the literature use metal-ions as the directing influence in ligand assembly (i.e. without the metal-ions, the ligands would not assemble into spheroidal structures). However the C-alkylpyrogallol[4]arene molecules can assemble into hexameric...
Applications of elemental analysis for archaeometric studies : analytical and statistical methods for understanding geochemical trends in ceramics, ochre and obsidian
(University of Missouri--Columbia, 2006)
Three areas are covered in this dissertation: elemental analysis of Caborn-Welborn ceramics, elemental analysis and geochemical characterization of ochres, and construction and implementation of a portable XRF instrument ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...
Studies of natural products that reveal novel strategies for efficient modification of DNA
(University of Missouri--Columbia, 2006)
DNA is the central molecule in cells. The correct function of cells depends on the structure of DNA. DNA damaging natural products often show cytotoxic or mutagenic properties, which many times land them medicinal value ...
Studies of the chemistry of Tröger's base, cyclopentadienones, and 2,1-benzothiazines
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The sequential alkylation of Tröger's base was developed for the synthesis of symmetric dialkylation analogs. The products from this reaction were ...
Synthesis of silyloxyacrolein for [4+3] cycloaddition and preparation of carbonate closomer
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Followed by Funk's method, I synthesized silyloxyacroleins and used them as dienophiles to react with different dienes in [4+3] cycloaddition reaction. ...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Anisotropic organic materials are attracting increasing interesting for their highly electro-optic characteristics. We are especially interested in ...
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and ...
Evaluating the suitability of the human toenail as a biomonitor for manganese status: the one source cohort
(University of Missouri--Columbia, 2007)
Numerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the hypothesis that Mn intake is reflected in toenail ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Determination of total selenium and seleno-amino acids in yeast and aquatic organisms by liquid chromatography and inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2007)
The primary goal of this dissertation research was to develop methods for routine speciation analysis of selenium in tissues. A method for total selenium using on-line stable isotope dilution analysis with conventional ...
Organo nickel and platinum chemistry at the edge of corannulene
(University of Missouri--Columbia, 2007)
of corannulene, nickel and platinum corannulene complexes and derivatives are reported. Potential metal mediated functionalization method of PAHs via directing halogenation of C-H bond is established by photoinduced selective bromination. Therefore, this research...
From carbon to copper : studies of novel nanomaterials
(University of Missouri--Columbia, 2007)
structures reported are compared, and their potential applications are also discussed....
High valent uranium dioxo and imido complexes : synthesis and structure
(University of Missouri--Columbia, 2008)
, and uncovers the influences imparted by a variety of functional ligand designs. In the opening report, salicylidene derived Schiff base chelates adapt to equatorial coordination and control uranyl(VI) photo- and electrochemical activity. In the second study, a...
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family that has two subtypes: sigma1 and sigma2. Sigma1 receptors are involved in several physiological functions such as psychosis and depression. Sigma2 receptors are expressed in ...