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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
(University of Missouri--Kansas City, 2012-10-02)
Herpes simplex virus infections (HSV) in the eye are one of the leading causes of blindness across the world. Current available treatment options to treat HSV infections are solutions of trifluorothymidine (TFT), idoxuridine ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
(2014-08-28)
Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic
intracellular drug concentration, is one of the predominant factors limiting effective cancer
chemotherapy. Several possible mechanisms and ...
Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
(University of Missouri--Kansas City, 2011-01-20)
HIV/AIDS has become one of the greatest threats to human health. Although inclusion of protease inhibitors (PIs) in HAART has greatly slowed the disease progression and improved the outcome of clinical treatment, the ...
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
The objective of this dissertation is to present the various therapeutic approaches for two distinctly different diseases, prostate cancer and type-1 diabetes. Our objective (1) for prostate cancer is to evaluate the siRNA ...
Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
(University of Missouri--Kansas City, 2017)
The bacterial cell wall is made up of peptidoglycan (PG) and its synthesis is of
interest as a target for several antibiotics and for new inhibitor development. Peptidoglycan
biosynthesis is a complex process which ...
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to design and optimize a nanoformulations
(nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for
HIV prevention in women.
In chapters 1 and ...
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
Design and optimization of nanoformulation loaded with HIV microbicides
(2013)
review of its technical background. In chapter 3, the formulation and process variables involved in the production of spray-dried oily-core nanocapsules (NC) are investigated using Box-Behnken Design (BBD) and Fractional Factorial Experimental Design...
Preparation, Characterization and Performance Study of Modified Titanium Dioxide Nanocrystals for the Lithium-Ion Battery
(2015-08-04)
The lithium-ion battery is one of the most widely used rechargeable batteries in
today’s life. As an energy storage device, it can convert the stored chemical energy into
electrical energy when it is being used. Titanium ...
Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
(University of Missouri--Kansas City, 2012)
Recurrent brain tumors are one of the most lethal forms of solid tumors with poor
prognosis. Molecularly targeted therapy, inhibiting the tyrosine kinase domain of
epidermal growth factor receptor (EGFR), platelet derived ...
Formulation of nanoparticles encapsulating hydrophilic molecules following their ionic complexation
(University of Missouri--Kansas City, 2011-06-01)
Part 1: Dexamethasone is one of the most widely used drug molecules for the treatment of posterior segment ocular diseases. The major problems associated with the delivery of dexamethasone include its poor aqueous solubility ...
Molecular structure determination: solid-state NMR applications
(University of Missouri--Kansas City, 2012-12-14)
Solid-state Nuclear Magnetic Resonance (ssNMR) has become one of the best
techniques to determine molecular structure via inter/intra-molecular interactions.
Unlike the well-known solution state NMR, solid-state NMR ...
Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
(University of Missouri-Kansas City, 2011-12-21)
Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of
the most common infectious diseases causing corneal blindness in the United States. In this
study, polymeric nanoparticles ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)
We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ...
Novel Approaches for Targeted Delivery of Cancer Therapeutics to Nuclei of Malignant Cells
(University of Missouri--Kansas City, 2016)
The primary goal of this project is to increase specific uptake of anti-cancer therapeutics by
nuclei of cancer cells. A lot of research has been done to target therapeutics specifically across
plasma membrane of ...
Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
(2015-06-19)
Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized.
Low molecular weight diblock co-polymers, ...