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The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
involved in the pathology of dementia. One promising intervention may appear to be beneficial for MCI is creatine (Cr), which has been proven to be effective for ameliorating cognitive deficiency in general. However, it is unclear whether Cr supplementation...
Maladaptation of cardiac and skeletal muscle in chronic disease : effects of exercise
(University of Missouri--Columbia, 2007)
OLEFT rat. Lastly, Part III (supplemental) provides a brief discussion on the effects of caloric restriction in obesity....
The effects of physical activity on adipose tissue metabolism and DNA methylation
(University of Missouri--Columbia, 2009)
The increased prevalence of obesity and diabetes threatens both the real and economic health of Western counties. There were two major goals of this dissertation, 1) to determine if in response to inactivity and hyperphagia ...
Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)
decreased Glutamate AMPA Receptor 1 (GluA1) protein levels, and neurogenesis. Our genetic model for high physical activity on the other hand had enhanced performance in cognitive behavioral testing, increased hippocampal volumes, and increased markers...