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An Electro-magnetic cell stimulator [abstract]
(2010-03)
A device to stimulate bone and muscle cell growth and possibly for treatment of bone and muscle injuries is presented. The device, called EStim, generates electric and magnetic pulses at programmable intervals. This device ...
Creation of 'Super Avastin': A New Nanomedicine Approach for the Treatment of PXE and AMD [abstract]
(2010-02)
Nanomedicine is an emerging medical area that utilizes nanoparticles for the detection and treatment of diseases. The ubiquitous place of gold in Nanomedicine stems from its chemical ability to serve in an unoxidized state ...
Clinical Translation of Nanopharmaceuticals for Cancer Therapy [abstract]
(2010-02)
The most recent study involving 77,000 North American men has shown that regular prostate specific antigen (PSA) screening did not provide accurate diagnosis of prostate cancer and therefore did not save lives of cancer ...
Acid-sensing ion channels as a novel target for drug addiction [abstract]
(2010-03)
Improving the treatment and prevention of drug addiction is an important goal for modern medicine. Ion channels have recently become very attractive targets in the search of new pharmacotherapies. Extracellular proton ...
Nanostructures for Diagnostics and Delivery [abstract]
(2010)
Nanostructures are increasingly being recognized for their novel applications in biological systems including nanomedicine— the application of nanoscale technologies for diagnosis, treatment and prevention of diseases. ...
Mechanism-based Inhibitor of Matrix Metalloproteinase-9 Rescues Brain from Focal Cerebral Ischemia-induced Damage and Improve Neurological Outcomes in Mice [abstract]
(2010-02)
Stroke is the third leading cause of death in the US and the primary cause of long-term disability. Acute ischemic stroke, the most common form of stroke, is caused by clotting in the cerebral arteries leading to brain ...
Quantitative Profiling of S-Nitrosylated Proteins in Parkinson's Disease Paradigms for the Effects of Botanical Phenolics [abstract]
(2010-02)
A convergent feature for most aging-related neurological diseases, such as Parkinson's Disease (PD), is excessive generation of free radicals - reactive nitrogen and oxygen species, which can contribute to neuronal cell ...
Comparative oncology and clinical translation of glyco protein conjugated gold nano therapeutic agent (GA-198AuNP) [abstract]
(2010)
As part of our efforts toward clinical translation of GA-198AuNP, our studies are focused on therapeutic efficacy of nanoparticulate GA198AuNP agent in dogs with prostatic carcinoma. The overall goal is to gain clinical ...
UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT) [abstract]
(2010-03)
Diseases of mineralized tissues such as bone and teeth or of the muscles that control bone movement result in significant health costs in terms of suffering, loss of work and productivity, and even death. There is a ...
Targeting the guanylate cyclase c receptor with an agonist peptide from enterotoxegenic Y. Enterocolitica [abstract]
(2010-03)
Heat-stable enterotoxin peptides (ST's) are expressed by enterotoxigenic strains of bacteria in order to co-opt an endogenous ligand-receptor system that regulates fluid homeostasis within the gut. Bacteria such as E. coli, ...
Applications of Energetic Materials and Copper Oxide Nanorods for Decontamination [abstract]
(2010-03)
We demonstrate the potential of nanoenergetic coatings and CuO nanorods to decontaminate surfaces infected with bacteria. The methods of decontamination include (i) fast combustion of an energetic paint applied on contaminated ...
Investigation and Optimization of Silorane-Based Polymer System [abstract]
(2010-03)
This research is a collaboration between Department of Oral Biology in the School of Dentistry at UMKC, Department of Chemistry in The College of Arts and Sciences at UMKC, Department of Chemistry at Missouri Science and ...
Translational Approach to Examine the Importance of Aerobic Fitness on Nonalcoholic Fatty Liver Disease [abstract]
(2010)
Low cardiorespiratory fitness, independent of physical activity levels, is the best predictor of early mortality and is linked to type 2 diabetes and CVD. In the absence of exercise training, it is believed that genetic ...
Derivation and characterization of LIF and FGF2 dependent Porcine Induced Pluripotent Stem Cells [abstract]
(2010-02)
Authentic embryonic stem cells (ESC) have probably never been derived from the inner cell mass (ICM) of pig, despite over 25 years of effort. Recently, several groups, including ours, have reported derivation of induced ...
The use of the Nintendo Wii for balance and cognition as a trement modality in occupational therapy in persons with multiple sclerosis for increased independence in activities of daily living [abstract]
(2010-03)
Objective: Examine the effectiveness of the Nintendo Wii on balance and cognition deficits to increase independence in activities of daily living for an individual with MS. Design: ABA single subject experimental design ...
Development of an in vitro model of quail vasculogenesis [abstract]
(2010-02)
Blood supply to virtually all tissues depends on endothelial cells, which form the linings of blood vessels. Growth and formation of endothelial cells occurs in two ways. Vasculogenesis describes the initial proliferation ...
Estrogen receptor and estrogen related receptor may corporatley regulate hypoxic gene expression [abstract]
(2010-03)
Tumor cells can undergo adaptation to the hypoxia environment created by rapid growth of tumor cells to persist growing. A main regulator of hypoxia induced gene expression is hypoxia-inducible factor (HIF), and HIF can ...
Skeletal Muscle - Bone Crosstalk Regulating Osteocyte Function [abstract]
(2010-03)
Osteocytes are thought to be the primary cell in bone that responds to mechanical loading and the traditional view is that skeletal muscle's role relative to bone is in the application of those loads. We have hypothesized ...
A Single Antibody based ELISA for the N-terminal sequence of BAG-75, a New Biomarker for Bone Formation [abstract]
(2010)
Bone acidic glycoprotein-75 (BAG-75) is a secreted product of osteoblastic cells localized predominantly to areas of new bone formation. We have identified the N-terminal sequence of BAG-75 as LPVARYQNTEEEE and shown that ...
Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]
(2010-03)
We present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 ...