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The utility and limitations of the TRAMP model system for studying the effects of hedgehog targeted therapy in prostate cancer
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Advanced prostate cancer has a very poor prognosis and no curative therapies. Understanding of the hedgehog (Hh) signaling pathway, a potential target ...
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR required for initiation of autoimmune neuroinflammation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Posttranscriptional gene regulation is a critical mechanism of controlling the gene expression. The RNA binding-proteins (RBPs) mediate RNA splicing, ...
Arsenic speciation of swine urine for possible use in human exposure assessments
(University of Missouri--Columbia, 2013)
Commonly found arsenic species in human urine are AsIII (arsenite), AsV (arsenate), MMA (monomethyl arsenic acid), DMA (dimethylarsinic acid) and AB (arsenobetaine). Evidence has shown that these species vary in toxicity ...
Identification of factors that promote satellite cell motilityIdentification of factors that promote satellite cell motility
(University of Missouri--Columbia, 2014)
An important but poorly understood aspect of stem cell-mediated skeletal muscle regeneration is stem cell recruitment and motility within the damaged tissue; a failure to spread after therapeutic engraftment is also a key ...
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia
(University of Missouri--Columbia, 2013)
Inflammatory bowel disease (IBD) is one of the most common immune-mediated diseases in the United States costing the average patient tens of thousands of dollars annually, and greatly diminishing quality-of-life. While ...
Ecomorphological implications of primate dietary variability: an experimental model
(University of Missouri--Columbia, 2013)
The evolution and function of the mammalian skull and feeding apparatus is intimately related to the mechanical demands imposed by food items. The diets of wild species are often seasonal and thus individuals may experience ...
Defining the therapeutic window in spinal muscular atrophy :time points study
(University of Missouri--Columbia, 2013)
Spinal muscular atrophy (SMA) is caused by the loss of a single gene, survival motor neuron-1 (SMN1), which results in the rapid deterioration of motor neuron integrity and function, most often leading to infantile death. ...
Biochemical characteristics of different subtypes of human immunodeficiency virus type 1 reverse transcriptase and its interactions with the host factor : apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Human immunodeficiency virus (HIV) is divided into type 1 (HIV-1) and type 2 (HIV-2). Whereas HIV-2 accounts for 5% of global infections, HIV-1 is ...
Examine the role of minor splicing pathway in spinal muscular atrophy
(University of Missouri--Columbia, 2014)
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder mainly caused by deletions or mutations of one gene, Survival Motor Neuron (SMN). SMN is crucial in splicing processes for proper gene expression. Previous ...
Mapping the language-specific cerebrocerebellar network of the human brain through diffusion tensor imaging
(University of Missouri--Columbia, 2015)
Language was arguably a key influence in the evolution of the human brain and the evolution of this behavior in humans was likely associated with gross morphological changes and novel neural networks. My dissertation looked ...
Universal blood : the life stream all four one and one for all : an enzymatic methodology creating a universal blood supply
(University of Missouri--Columbia, 2012)
α-NAGA (α-N-acetylgalactosaminidase) is an exoglycosidase that cleaves a specific carbohydrate, terminal linked 1-3 α-N-acetylgalactosamine, from the A antigen. The enzymatic hydrolysis creates the H antigen. This modification ...
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)
Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ...
Discovery of novel hepatitis B virus (HBV) antivirals and analysis of mechanisms of action of HBV-targeting agents
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chronic hepatitis B virus (HBV) infection leads to liver disease, cirrhosis, and hepatocellular carcinoma. Globally, an estimated 50% of all hepatocellular ...
Transcriptional regulation of ADAM-12 expression under normal and osteoarthritic conditions
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] ADAM 12 overexpression is linked to the pathology of diseases including osteoarthritis, cancer, cardiac hypertrophy, Alzheimers and multiple sclerosis. ...
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ...
Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)
Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...
Advances in the fundamental cryobiology of mammalian oocytes
(University of Missouri--Columbia, 2007)
Having effective means to cryopreserve mammalian oocytes could increase the efficiency of managing populations of laboratory animals, increase the effectiveness of breeding programs for livestock, and improve the means by ...
The role of load in initiation and progression of cartilage pathology
(University of Missouri--Columbia, 2007)
Articular cartilage is primarily responsible for dissipation of load in diarthrodial joints. Load plays a critical role in maintaining cartilage health, but can also be a primary contributing factor in cartilage disease ...
Isolation, characterization, and diagnosis of murine noroviruses, a newly recognized pathogen of mice
(University of Missouri--Columbia, 2007)
Murine norovirus (MNV) is a newly recognized pathogen of mice. To assess the extent of MNV infection in laboratory mice, a high-throughput serologic diagnostic assay termed the multiplex fluorescent immunoassay (MFI) was ...
Comparative fundamental cryobiology of mouse embryonic stem cells
(University of Missouri--Columbia, 2009)
Mouse embryonic stem cell (mESC) lines are central to projects such as the Knock-Out Mouse Project, which seek to create thousands of mutant mouse strains using mESCs for the production of human disease models. The ability ...