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Mapping the language-specific cerebrocerebellar network of the human brain through diffusion tensor imaging
(University of Missouri--Columbia, 2015)
Language was arguably a key influence in the evolution of the human brain and the evolution of this behavior in humans was likely associated with gross morphological changes and novel neural networks. My dissertation looked ...
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR required for initiation of autoimmune neuroinflammation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Posttranscriptional gene regulation is a critical mechanism of controlling the gene expression. The RNA binding-proteins (RBPs) mediate RNA splicing, ...
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ...
Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. The research goal was to ...
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)
Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...
Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)
Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...
Universal blood : the life stream all four one and one for all : an enzymatic methodology creating a universal blood supply
(University of Missouri--Columbia, 2012)
α-NAGA (α-N-acetylgalactosaminidase) is an exoglycosidase that cleaves a specific carbohydrate, terminal linked 1-3 α-N-acetylgalactosamine, from the A antigen. The enzymatic hydrolysis creates the H antigen. This modification ...
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)
Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ...
A study on three aspects of inflammatory bowel disease's triad of susceptibility : hormones, helminths and T regulatory cells, in the Helicobacter hepaticus mouse model for IBD /
(University of Missouri--Columbia, 2014)
Over 1.4 million American's have been diagnosed with an Inflammatory Bowel Disease (IBD). The etiology of IBDs is unknown, however, it is believed that these diseases develop due to an inappropriate immune response to the ...
The evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilage
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage ...
Examine the role of minor splicing pathway in spinal muscular atrophy
(University of Missouri--Columbia, 2014)
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder mainly caused by deletions or mutations of one gene, Survival Motor Neuron (SMN). SMN is crucial in splicing processes for proper gene expression. Previous ...
Discovering disease causing variants in dogs through whole genome sequencing
(University of Missouri--Columbia, 2017)
This dissertation focuses on the use of whole genome sequencing (WGS) for the identification of disease causing variants in canine genomes. A brief review on the historical milestones of genetics, the creation and ...
Dietary nutrients implicated in the etiopathogenesis of human and animal diseases
(University of Missouri--Columbia, 2017)
Hyperthyroidism is a spontaneous disease that results in an abnormal elevation of circulating concentrations of one or more thyroid hormones. Despite being the most commonly diagnosed endocrine disorder of domestic cats, ...
Yersinia pestis YopJ, YopT, and YopK coordinate programmed cell death and cytokine responses to promote pneumonic plague
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Yersinia pestis has been responsible for three major pandemics of plague, including the infamous Black Death that killed 250 million people in Europe. ...
Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the ...
Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In the United States, prostate cancer is the most commonly diagnosed cancer and the third leading cause of cancer related deaths in men. With early ...
Adding pieces to the monocytic ehrlichiosis puzzle : treatment, etiology and protection with a canine model
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Infections with Ehrlichia canis cause Canine Monocytic Ehrlichiosis (CME), a disease which causes morbidity and mortality of dogs worldwide. Currently, ...
Microbiota modulation of behavior and stress responses : implications for neuro-immune research in zebrafish
(University of Missouri--Columbia, 2016)
The gut microbiota (GM) consists of a large microbial community whose collective set of genes encodes a vast array of functions. These microbes play a major role in many physiological processes within the host and are ...
Investigation of novel therapeutic strategies for attenuating corneal fibrosis
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corneal fibrosis (scarring) is a significant cause of vision loss worldwide resulting from an exuberant wound healing response driven in part by the ...
Cellular and molecular mechanisms underlying immune tolerance against type 1 diabetes /
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D), also known as insulin-dependent diabetes mellitus, is a chronic autoimmune disease caused by the destruction of insulin-producing ...