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Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)
Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ...
I. Structure-Activity Relationship Studies of 6,7-Annulated-5-Substituted Libraries. II. Current Efforts Towards The Synthesis of 4-Azaindole Aryne Precursors
(2015)
A contemporary and highly valued method for drug discovery involves the synthesis of libraries or collections of novel compounds from interesting molecular scaffolds, often inspired by biologically active, naturally occuring ...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ...
Indole Arynes in organic synthesis : discovery and applications for the total synthesis of complex natural products
(University of Missouri -- Kansas City, 2011-05-03)
Arynes and heteroarynes are very important and useful reactive intermediates with many applications in organic synthesis, including natural products total synthesis. Although benzyne, the parent and most famous aryne, has ...
Evaluation of therapeutic effect of PCBP2 siRNA on hepatic stellate cells and development of a streptavidin-based siRNA delivery system
(2014)
Type I collagen accumulates during liver fibrosis primarily because α-complex protein-2 (αCP2), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3′end of the collagen mRNA and increases its half-life. ...
Enantioselective hydrolysis of 1-arylpropargylic esters by enzymatic kinetic resolution and dynamic kinetic resolution of 1-arylallylic esters
(2013)
racemization and will report our results for In and Cu compounds. While kinetic resolution has been performed on the 1-arylallylic acetates with excellent yield and enantioselectivity and the DKR regime has been designed, the resulting site-isolation system has...
The Investigation of Configurationally Stable Longitudinally Twisted Acenes and the Development of a Silorane-Based Biomaterial for Use as an Antimicrobial Delivery Device
(2019)
Longitudinally twisted acenes (LTAs) adopt a helical twist in order to alleviate steric congestion caused by bulky substituents along the acene backbone and are inherently chiral. As is observed in helicenes, this helical ...
Studies of Conjugated Small Molecules, Polymers and Organic-Inorganic Hybrid Materials for Photovoltaic Applications
(2015)
This dissertation focuses on the photophysical properties and device studies of three different types of materials, namely polyoxometalate (POM)-containing organic-inorganic hybrids, near-IR absorbing conjugated polymers ...
Engineering of Human Acid Phosphatase Enzyme Sensitive Nanomedicine for HIV/AIDS Prevention by Topical Route
(University of Missouri -- Kansas City, 2018)
This study is divided into two aims. Aim #1 focuses on the development and
characterization of tenofovir (TFV) loaded a stimuli sensitive nanomedicine against male to
female HIV/AIDS infection. Aim #2 focus on the ...
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
(2013)
Total synthesis of benzannulated indole alkaloid natural products (±)-cis-trikentrin B,
(±)-herbindole A and (±)-herbindole B via intermolecular indole aryne cycloaddition are
described. The 5,6,7-tribromoindole was ...
Part I: The synthesis of chenodeoxycholic acid derived macrocyles and cage compounds. Part II. Sonogashira coupling for the synthesis of well-defined π-conjugated arylene ethynylene oligomers as blue-light-emitting materials
(University of Missouri--Kansas City, 2012-01-20)
The design and development of novel chenodeoxychoic acid (CDCA) derivatives and its molecular architecture was accomplished. A novel CDCA derivative with an ambient CO2 insertion to 7α-side chain has been serendipitously ...
Conformational and Structural Determinations of Substituted Four and Five Membered Rings by Infrared, Raman, and Microwave Spectral Studies
(2014)
Studies of the structure and conformational stabilities of molecules have become
increasingly important due in part to advances in the fields of biochemistry and nanochemistry.
Specifically the conformation of organoamines ...
The Bulk and Interfacial Electronic and Chemical Structure of Amorphous Hydrogenated Boron Carbide
(2013)
The chemical and electronic structure, as related to the surface, interface and bulk of amorphous hydrogenated boron carbide (a-BxC:Hy), is of interest in neutron detection and microelectronics. This dissertation investigates ...
Development and Evaluation of Nanocarriers against Atherosclerosis
(University of Missouri--Kansas City, 2016)
The objective of this project was to develop advanced nanocarriers such as
nanographene and graphene quantum dots against atherosclerosis. Mannosylated-reduced
graphene oxide (Man-rGO) was developed as a targeted ...
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)
We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ...
Conformational stability of some silanes and amines from temperature dependent Infrared spectra of rare as solutions, r₀ structural parameters, ab initio calculations, and vibrational assignments
(University of Missouri--Kansas City, 2012-06-12)
rotation are also reported for some of the silane molecules. Potential functions governing conformational interchange were also determined, based on torsional transitions frequencies, conformational enthalpy differences and dihedral angles...
Organoisocyanates: the conformational stability determination by infrared, raman and microwave spectroscopy and ab initio calculation
(University of Missouri-Kansas City, 2012)
Conformational stability studies have been carried out for several quasilinear organoisocyanates and organoisothiocyanates. The infrared and Raman spectra in the gaseous, liquid and solid phases have been recorded as well ...
The Study of Initiation Systems and Formulations for the Development of a Novel Silorane Biomaterial
(2015)
change to their
composition. They provide strength and longevity for total joint replacements, however
they are not without their disadvantages. Issues such as polymerization shrinkage, high
curing temperatures, and component toxicity have been reported...
Design, synthesis, characterization and photovoltaic applications of conjugated polymer hybrids containing coordinatively binded semiconducting nanocrystals
(2014-07-17)
polymer. They are found to form close and intimate contacts with both TiO2 through carboxylic acid binding and P3HT polymer presumably by way of π–π interaction. The resulting hybrid solar cells showed the highest photocurrent ever reported among...