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Meiotic aspects of chromosome organization : (meiosis, pachytene DNA)
(University of Missouri, Agricultural Experiment Station, 1983)
Homologous chromosome pairing regulates the expression of a set of metabolic activities that is unique to the zygotene-pachytene interval , These activities probably relate to crossing-over and they involve specific proteins ...
Pattern formation in the drosophila embryo : (Developmental genetics, combinatorial code, compartments)
(University of Missouri, Agricultural Experiment Station, 1981)
Three plausible hypotheses about developmental commitments in the Drosophila embryo propose: 1) A micromosaic of localized determinants in the egg trigger somatic commitments. 2) Monotonic anterior-posterior and dorsal-ventral ...
Chi sites, RecBC enzyme, and geneneralized recombination
(University of Missouri, Agricultural Experiment Station, 1981)
With the goal of elucidating the molecular basis of genetic recombination, our laboratory has studied special sites that promote recombination in their neighborhood and enzymes essential for recombination in Escherichia ...
Nuclear genes and chloroplast modifications in maize : (Zea mays, iojap , cytoplasmic inheritance, nucleus-cytoplasm interaction, sorting-out, morphological modifications)
(University of Missouri, Agricultural Experiment Station, 1982)
The recessive nuclear genes (ij) and chloroplast mutator (cm) in maize have been studied as examples of genes whose roles affect the continuity of the plastid and its genetic machinery. The phenotypic expression of cm is ...
Neurogenetics of courtship in drosophila : (courtship and mating, behavioral mutants, Drosophila gynandromorphs, visual and olfactory defects, circadian rhythms, learning and memory, neurotransmitter mutants)
(University of Missouri, Agricultural Experiment Station, 1980)
Courtship behavior in Drosophila is programmed by the action of genes that control the development and function of the nervous system. Several genes have been identified that appear to be involved in reproduction, because ...
The integration of human DNA and expression tumor virus genes : (cell transformation, transcription, integration, human cancer)
(University of Missouri, Agricultural Experiment Station, 1980)
DNA tumor viruses offer excellent model systems to study the molecular biology of eucaryotic cells and to establish the molecular basis for cell transformation. Our laboratory has focused on the human adenovirus type 2 ...
Evolution of DNA sequence : mechanisms and models as seen in small phages : (small isometric phages, evolution of their nucleotide sequence, duplication, deletion, overlapping genes, secondary structure)
(University of Missouri, Agricultural Experiment Station, 1980)
Extensive nucleotide sequence data is new known for six small isometric phages, ([o with diagonal slash]Xl 74, G4, St-1, Sl3, [lowercase alpha]3 and [phi]K).Comparison of these sequences allows us to observe the role of ...
Tailoring the agrobacterium Ti plasmid as a vector for plant genetic engineering : (site specific insertions, chimeric gene construction, regeneration of plants containing T- DNA)
(University of Missouri, Agricultural Experiment Station, 1981)
Agrobacterium tumefaciens and its tumor-inducing (Ti) plasmidi constitute a promising vector system for the introduction of desirable genes into higher plant cells. This bacterialpathogen has an unusually wide host range, ...
The structure and function of yeast centromeres : (saccharomyces cerevisiae, yeast transformation, centromere cloning, functional minichromosomes , recombinant DNA, nucleotide sequencing )
(University of Missouri, Agricultural Experiment Station, 1981)
Segments of Saccharomyces cerevisiae DNA have been isolated that contain centromeric sequences (CEN3 and CEN11) from chromosomes III and XI. When present on a plasmid vector capable of replication in yeast (pLC544 or Yrp7), ...
Arrangement and rearrangement of the bacterial chromosome : (chromosome rearrangements, transposable elements)
(University of Missouri, Agricultural Experiment Station, 1981)
Several lines of evidence suggest that the arrangement of genes in the bacterial chromosome may have selective importance. To investigate the significance of chromosomal gene order and the effect of position on gene ...
A molecular analysis of three unstable alleles in drosophila : (transposable elements, mutable alleles, white locus)
(University of Missouri, Agricultural Experiment Station, 1982)
We have determined the structure of several unstable mutant alleles of the white locus in Drosophila melanogaster. The white ivory (w[superscript i]) allele is a moderately unstable allele, which gave rise to the highly ...
Nuclear control of the expression of the cytochrome b gene in yeast mitochondrial DNA : (apocytochrome b gene, Saccharomyces cerevisiae, CBP1 gene)
(University of Missouri, Agricultural Experiment Station, 1982)
The mitochondrial gene encoding apocytochrome b is mosaic, containing two intervening sequences in the Saccharomyces cerevisiae strain D273-10B. Five nuclear genes and one mitochondrial gene have been identified that are ...
Meiotic mutants in potato breeding : (haploids, 2n gametes, germplasm transfer)
(University of Missouri, Agricultural Experiment Station, 1982)
Three factors provide unusual opportunities for potato improvement: (1) The wild and cultivated tuber-bearing relatives of the potato represent a large source of valuable germplasm. This genetic diversity can be incorporated ...
Bacteriophage 16-3 of Rhizobium meliloti and its pattern of recombination : (Rhizobium, phage - vector, recombination)
(University of Missouri, Agricultural Experiment Station, 1982)
The ontogenetic and evolutionary origins of antibody diversity : (antibody diversity, ontogeny, evolution, transposable elements)
(University of Missouri, Agricultural Experiment Station, 1982)
Three ontogenetic origins of antibody diversity have been identified. First, there is a large number of germline gene segments. Second, multiple combinatorial strategies are used to amplify antibody diversity. These include ...
Somatic cell genetic analysis of the interferon system : (interferon genetics, interferon receptors , cell hybrids )
(University of Missouri, Agricultural Experiment Station, 1981)
The interferon system is amenable to somatic cell genetic analysis since the genes governing the synthesis of interferon and the cellular responses to interferon can be expressed in tissue culture cells. Limited species ...
Characteristics of cms-S reveversion to male fertility in maize : (cytoplasmic male sterility, male fertility restoration S-type cytoplasm, mitochondrial DNA)
(University of Missouri, Agricultural Experiment Station, 1981)
The association of cytoplasmic reversion of cms-S male-sterile strains to male fertility with disappearance of the S1 and S2 mtDNA plasmids as discrete molecules has been established for all 23 cytoplasmic revertant strains ...
Divergent and concerted evolution of the two regions encompassing the iso-1- cytochrome c and iso-2-cytochrome c genes of yeast : (saccharomyces cerevisiae, cytochrome c of yeast, evolution of yeast, cloning yeast genes, recombinant DNA, transpositions, composite genes)
(University of Missouri, Agricultural Experiment Station, 1982)
The yeast Saccharomyces cerevisiae contains a cluster of three genes CYC1-0SM1-RAD7, denoted COR, located on the right arm of chromosome X and a cluster of three genes ANP1-RAD23 -C YC7, denoted ARC, located on the left ...
The mechanism and control of Tn5 transposition
(University of Missouri, Agricultural Experiment Station, 1982)
Analyses of transposition from pBR322
Transposable elements and genetic instabilities in crop plants : (controlling elements, recurrent mutations, hybrid dysgenesis, somatic mutations, tissue culture)
(University of Missouri, Agricultural Experiment Station, 1981)
Transposable elements have long been associated with certain unstable loci in maize and have been intensively studied by McClintock and others. It is known that a transposable element can control the expression of the ...