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Using genetically diverse Collaborative Cross mouse strains to model SCN1A-related Dravet Syndrome
(University of Missouri--Columbia, 2024)Dravet Syndrome (DS) is classified as a rare neurodevelopmental and epileptic encephalopathy (DEE), characterized by persistent seizures, developmental delays, speech impairments, sleep disruptions, and other comorbidities. ... -
Relationship among body mass index, survival, and health-related quality of life among older patients with bladder cancer
(University of Missouri--Columbia, 2024)INTRODUCTION: The relationship between body composition and bladder cancer outcomes is complex. A higher Body Mass Index (BMI) seems to predispose to the development of bladder cancer, though the impact on survival is more ... -
Design and implementation of a tailored data management system for a rural cardiovascular clinic
(University of Missouri--Columbia, 2024)Health Information Technology (HIT) adoption and meaningful use continues to be a challenge in rural healthcare, specifically in Critical Access Hospitals (CAHs) and smaller clinics. This study addresses the gap in effective ... -
Association between Health-Related Quality of Life measures with bladder cancer characteristics and survival outcomes in older bladder cancer patients : a clustering approach
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 12/01/2024] Introduction: Bladder cancer significantly impacts the physical and mental well-being of elderly patients. This study employs clustering algorithms to 1) categorize patient survival based on ... -
Acetate mutants and obligate photoautotrophy in Chlamydomonas eugametos
(University of Missouri--Columbia., 1971)Incorporation of C-14 labelled sodium acetate by three species of Chlamydomonas: C. eugametos, C. reinhardii and C. moewusii indicates that all three species assimilate and metabolize exogenous acetate. All three species ... -
Cytogenetic analysis of a knobbed chromosome 9 in maize
(University of Missouri--Columbia., 1971)The K* knob of Mexican origin had a suppressive effect on recombination in the short arm of chromosome 9. It had the capacity to reduce recombination in both the distal and proximal regions or to reduce it only in the ... -
The role of tumor-associated macrophages in pancreatic cancer
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 8/1/2024] Due to the lack of early diagnosis and efficient therapy, it is projected that pancreatic cancer (PaC) will become the second leading cause of cancer-related death in the U.S. by 2030. Conventional ... -
Impact of the NAD+ salvage pathway on the motor system and bioenergetics
(University of Missouri--Columbia, 2023)Nicotinamide adenine dinucleotide (NAD+) is a metabolite pivotal to numerous cellular functions, including energy metabolism, DNA repair, and protein modification. The majority of NAD+ is generated by the NAD+ salvage ... -
Neurochemical, epigenetic, and structural brain changes associated with prenatal stress exposure, and the mitigating effects of DHA
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that in utero stress exposure can modify developmental trajectories, influencing adult health. Research indicates that ... -
Investigating the long-term effects of non-inertial low-intensity blast-induced mild traumatic brain injury in mice
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] In military contexts, mild traumatic brain injury (mTBI) is reported more than moderate or severe TBI and is frequently caused by low-intensity blast (LIB) exposure. Affected service members and ... -
A case-control based genomic analysis of Chronic Obstructive Pulmonary Disease
(University of Missouri--Columbia, 2023)Chronic Obstructive Pulmonary Disease is a respiratory illness that affects a large number of people all over the world. It is a major cause of chronic morbidity and mortality and a serious global public health problem. ... -
A study to reduce the number of preventable emergency visits at community level
(University of Missouri--Columbia, 2023)Introduction: Emergency Department overcrowding is a worldwide issue. The impact of increased unnecessary and preventable emergency visits in hospitals leads to reduced quality of care, inability to care for critically ill ... -
Design and implementation of serverless architecture for i2b2 on AWS cloud and Snowflake data warehouse
(University of Missouri--Columbia, 2023)Informatics for Integrating Biology and the Beside (i2b2) is an open-source medical tool for cohort discovery that allows researchers to explore and query clinical data. The i2b2 platform is designed to adopt any patient-centric ... -
Explainable artificial intelligence to stratify pan-cancer patients for immune checkpoint inhibitor decision making
(University of Missouri--Columbia, 2022)Immune checkpoints are a normal part of the immune system. It engages when proteins on the surface of immune cells called T cells recognize and bind to partner proteins on other cells, such as some tumor cells. Immune based ... -
Accelerating data-driven discover in type 1 diabetes: an informatics-based approach
(University of Missouri--Columbia, 2022)Type 1 diabetes (T1D) is a lifelong chronic disease characterized by the absolute or near-absolute loss of insulin. For affected individuals, management of T1D is an unremitting challenge that involves constant blood glucose ... -
Interactions between light and carbon dioxide availabilities as a control of algal species succession
(1974)In attempting to gain knowledge of or insight into the requirements of algal production and the rate of algal production investigators turned to both field studies of natural water and laboratory studies. From these studies ... -
Characterization and dewaterability of water treatment plant residues
(1974)A variety of water treatment residues were characterized in order to determine the influence of specific chemical constituents, process flow schemes and raw water quality on the performance of sludge dewatering processes. ... -
Information dissemination in the water resources field
(1976)A study of mercury accumulation in trout taken from the trout parks and streams of southern Missouri is presented. Mercury in trout is determined by digestion in nitric acid, sulfurid acid, and potassium permanganate, ... -
Integrating the effects of the Great Flood of 1993: changes in groundwater hydrology and quality in relation to changes in surface waters
(1994)The Great Flood of 1993 had far-reaching impacts upon surface waters in the State of Missouri. Many stations along the Missouri River were above flood stage for months during the summer of 1993. Researchers conducted ... -
Analysis of social, fiscal, and structural factors affecting integrated pest management programs in Missouri and implications for future programs to protect water quality
(1996)Integrated Pest Management (IPM) has experienced a resurgence of interest due in part to continuing reports of drinking water contamination by agricultural pesticides. In response to the decertification of certain pesticides ...