Abstracts (Missouri Regional Life Sciences Summit 2010)
This collection contains the abstracts for the three types of sessions of the Missouri Regional Life Sciences Summit 2010: posters; presentations; plenary speakers. Please enter text in the search box above or click on one of the browse options to explore this collection.
Items in MOspace are protected by copyright, with all rights reserved, unless otherwise indicated.
Recent Submissions
-
Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]
(2010-03)We present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 ... -
Temporal trends in the management of severe hyperglycemia among patients hospitalized with acute myocardial infarction [abstract]
(2010)Background: Elevated blood glucose (BG) is associated with an adverse prognosis in acute myocardial infarction (AMI) patients. While guidelines recommend insulin therapy to lower markedly elevated BG in AMI patients, it ... -
Small Business Support for Youth Physical Activity Opportunities
(2010-03)Background: Increasing the number of youth physical activity opportunities (YPAO) (e.g., programs) may be a promising approach for encouraging physically active lifestyles among youth. To do this effectively, we need ... -
Dangerous Drug Reactions on the S&A iPhone App [abstract]
(2010)The S&A drug database for handhelds, sold to dermatologists for 8 years, was uploaded as a new iPhone application (app), February 2010. Our program notes all warnings at the several FDA levels: boxed warnings, bold warnings, ... -
INFORMER and Potassium Values: A system to enhance detection, notification, and action upon a threat to patient safety in the emergency department [abstract]
(2010)Background: Quick remediation should occur after critically abnormal potassium levels are detected by the medical laboratory in blood from emergency department (ED) patients. Critical potassium levels can be elevated ... -
Classification of Body Motions Based on Posturographic Data [abstract]
(2010)Introduction: The human body, while standing, can be modeled as an unstable feedback system. This produces a continuous sway pattern, which manifests itself as varying ground reactions that are measured with force plates ... -
A Comparative Study between Antibody and Peptide Conjugated Gold Nanoparticles for In Vivo Targeting of EGFR in Pancreatic Cancer Bearing Mice Models [abstract]
(2010-03)Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States due to its severe aggressiveness and lethal malignancy. Epidermal Growth Factor Receptor (EGFR) is over expressed in more than 95% ... -
Shock Wave Based Cell Transfection and Fluorescent Organosilicate Nanoparticles for Targeted Drug Delivery [abstract]
(2010)Nanotechnology is a multidisciplinary field that has applications in life sciences, alternative energy, national defense, and electronics. In the field of medicine, nanotechnology may enable intelligent drug delivery using ... -
Toxicty of a Serotonin-derived Neuromelanin
(2010)Introduction: POCD (Postoperative Cognitive Dysfunction) is associated with increased mortality and disability and may develop as a consequence of lipid peroxidative byproducts (i.e. acrolein), which accumulate with aging. ... -
Effects of Isoflurane on Plasma-Membrane Calcium ATPase
(2010-03)Introduction: Plasma membrane Ca2+-ATPase (PMCA) is a transmembrane enzymatic protein present in human neurons, myocytes, and RBCs which plays a role in controlling cellular Ca2+ levels by regulating intracellular ATP. ... -
Regulation of Phosphorylation of Dopamine D3 Receptors in Mouse Striatal Neurons in vivo
(2010-03)Introduction: Dopamine D3 receptors (D3Rs) are G-protein-coupled receptors. These D3Rs inhibit adenylyl cyclase and the downstream formation of cAMP. Due to their preferential expression in the mesolimbic areas, especially ... -
Amphetamine Alters Group I mGluR Expression in the Rat Striatum and Medial Prefrontal Cortex
(2010-03)Introduction: Group I metabotropic glutamate receptors (mGluR1/mGluR5 subtypes) and their key scaffolding protein Homer1b/c are densely expressed in the striatum. These receptors are believed to play important roles in ... -
Amphetamine Alters Acid-Sensing Ion Channel Expression in the Rat Striatum
(2010-03)Introduction: The acid-sensing ion channel (ASIC) is specifically activated by a drop in the extracellular pH level. These channels are widely expressed in mammalian brains and actively modulate synaptic transmission and ... -
Synaptic dysfunction in migraine: novel approaches for drug development [abstract]
(2010)Migraine is a severe paroxysmal neurovascular disorder, affecting up to 16% of the Western population. Current migraine drugs are largely targeted towards the pain associated with the migraine headache, and their efficacy ... -
Leveraging Particle Size and Structure to Control Release of Pharmaceuticals for Human and Animal Health [abstract]
(2010)Orbis Biosciences advances human and animal health pharmaceuticals and vaccines by leveraging controlled release platform technologies. Using Precision Particle Fabrication (PPF) technology, Orbis provides desired delivery ... -
Continuous Monitoring of Tissue Regrowth Using Optical Biosensors
(2010-03)The engineered regeneration of bone is a significant challenge being undertaken to treat conditions such as traumatic casualties, bone cancer, osteoporosis, etc. Advances in regrowth of hard tissue may potentially lead to ... -
A Study of RO5217790 (HPV Targeted Immunotherapy) in Patients With High Grade Cervical Intraepithelial Neoplasia Associated With High Risk HPV Infection
(2010-03)This is a randomized, double blind, placebo controlled, parallel group multicenter study in women with biopsy confirmed Grade 2 or Grade 3 cervical intraepithelial neoplasia (CIN). Two hundred patients will be enrolled and ... -
3q26 Amplification is Rarely Present in Women Whose LSIL Cytology does not Represent CIN 2+ Disease
(2010-03)Objective: 10-17% of women with LSIL cytology truly have CIN 2+ disease at colposcopically directed biopsy and 20% of the CIN 2+ lesions derive from women with LSIL cytology. No molecular marker has yet been able to triage ... -
Pancreatic islet transplantation to treat diabetes - defining molecular tools to select suitable islets [abstract]
(2010)A complete understanding of pancreatic islet biology is essential to the development of preventive or curative interventions for diabetes. It has been known that subpopulations of islets of different sizes exist; however, ... -
Development of Absorption and Fluorescence Probes Based on Mouse Model for Molecular Optical Imaging [abstract]
(2010)In this work we summarize our collaborative research on a project to develop absorption and fluorescence targeting probes. Several groups from University of Missouri and Harry S. Truman Memorial Veteran's Hospital including ...