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Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the ...
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)
Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...
Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In the United States, prostate cancer is the most commonly diagnosed cancer and the third leading cause of cancer related deaths in men. With early ...
Adding pieces to the monocytic ehrlichiosis puzzle : treatment, etiology and protection with a canine model
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Infections with Ehrlichia canis cause Canine Monocytic Ehrlichiosis (CME), a disease which causes morbidity and mortality of dogs worldwide. Currently, ...
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ...
Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. The research goal was to ...
Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)
Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)
Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ...
A study on three aspects of inflammatory bowel disease's triad of susceptibility : hormones, helminths and T regulatory cells, in the Helicobacter hepaticus mouse model for IBD /
(University of Missouri--Columbia, 2014)
Over 1.4 million American's have been diagnosed with an Inflammatory Bowel Disease (IBD). The etiology of IBDs is unknown, however, it is believed that these diseases develop due to an inappropriate immune response to the ...
Universal blood : the life stream all four one and one for all : an enzymatic methodology creating a universal blood supply
(University of Missouri--Columbia, 2012)
α-NAGA (α-N-acetylgalactosaminidase) is an exoglycosidase that cleaves a specific carbohydrate, terminal linked 1-3 α-N-acetylgalactosamine, from the A antigen. The enzymatic hydrolysis creates the H antigen. This modification ...
Kinetics of monocytotropic Ehrlichia infections, new insights from large animal models
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ehrlichia are tick-borne, obligate intracellular prokaryotic parasites found in host-derived parasitophorous vacuoles. The monocytotropic Erlichia ...
Ecomorphological implications of primate dietary variability: an experimental model
(University of Missouri--Columbia, 2013)
The evolution and function of the mammalian skull and feeding apparatus is intimately related to the mechanical demands imposed by food items. The diets of wild species are often seasonal and thus individuals may experience ...
Examine the role of minor splicing pathway in spinal muscular atrophy
(University of Missouri--Columbia, 2014)
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder mainly caused by deletions or mutations of one gene, Survival Motor Neuron (SMN). SMN is crucial in splicing processes for proper gene expression. Previous ...
The identification of a diagnostic biomarker panel for canine osteoarthritis
(University of Missouri--Columbia, 2010)
A novel biomarker panel for the diagnosis of early osteoarthritis (OA) in canines has been identified. This panel consists of monocyte chemoattractant protein 1 (MCP1), interleukin-8 (IL-8), keratinocyte-derived chemoattractant ...
Murine theiloviruses : characterization and pathogenesis of enteric and disseminated disease
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rat theilovirus (RTV), a member of the Theilovirus (ThV) species and closely related to Theiler's murine encephalomyelitis virus (TMEV), is a prevalent ...
Characterizing the progression of disease associated with human meniscal pathology
(University of Missouri--Columbia, 2013)
Meniscal fibrocartilaginous structures are subject to numerous stresses when performing its necessary functions to maintain intra-articular homeostasis. Pathological events causing a loss of tissue integrity will result ...
The evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilage
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage ...
Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction
(University of Missouri--Columbia, 2014)
Molecular genetic studies in canine inherited diseases including neonatal cerebellar ataxia, degenerative myelopathy and multiple system degeneration
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The inherited diseases of the domestic dog mimic a wide spectrum of common human disorders. By identifying the genes that harbor the mutations underlying ...
Inflammatory and cardiac response to end-stage pneumonic plague
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Yersinia pestis is the etiologic agent of pneumonic plague, a devastating disease in humans characterized by acute bronchopneumonia that is frequently ...