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Study of human pupillary light reflex and its potential application in autism
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pupillary light reflex (PLR) can be used as an objective and non-invasive method to evaluate certain brain functions. In this research, we developed ...
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
(University of Missouri--Columbia, 2007)
In order to produce a more versatile, adaptable, and effective method for detection of biological analytes, a self-contained and robust fluorescent optical biosensor architecture utilizing fluorescence resonance energy ...
Photoacoustic discrimination of viable and thermally coagulated blood for burn injury imaging
(University of Missouri--Columbia, 2007)
Early and accurate determination of burn depth is crucial to monitoring and treatment of the burn wound. One such treatment, surgical excision and grafting, involves removal of necrotic tissue from the wound and replacing ...
Characterization of membrane viscosity changes with the novel molecular rotor FCVJ
(University of Missouri--Columbia, 2007)
Membrane viscosity can be defined as the "thickness" of a cell membrane. Membrane viscosity conditions are a useful indicator of cell health. Many diseases have been reported to induce changes in afflicted cell membrane ...
Development of high-resolution optical tomography with a larger-size projection acquisition
(University of Missouri--Columbia, 2007)
In the industrial countries, the mortality from arteriosclerosis and cardiovascular diseases has been decreased, but they remain the most common circulatory disease. Recently, new tissue engineering technologies such as ...
Modeling of phototransduction in vision systems
(University of Missouri--Columbia, 2007)
To improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics ...
Development of a flexible image-based approach for studying signal transduction in isolated arterioles
(University of Missouri--Columbia, 2007)
Myogenic constriction in arterioles occurs when membrane tension leads to smooth muscle depolarization and voltage-gated calcium channel activation. A barrier to understanding the exact signaling events is the limited ...
Regulation of calcium signaling by p130PH in astrocytes
(University of Missouri--Columbia, 2009)
Ca2+ signaling is a characteristic form of astrocyte excitability, but its role in ischemia is not clearly understood. Our previous study (Ding et al., 2009) demonstrated that astrocytes exhibit enhanced Ca2+ signaling ...
Propagation of polarized light in skeletal muscle
(University of Missouri--Columbia, 2009)
Skeletal muscle is a very important tissue in animals and humans. Optical polarization imaging is a non-invasive method to study biological tissues and provides unique polarization contrast. An imaging system was developed ...
Applications of gel electrophoresis in quantum dot conjugates' separation and purification
(University of Missouri--Columbia, 2009)
The objectives of this study were to build Quantum dot (QD) crosslinker complexes for antibody conjugation usage, to purify QD crosslinker complexes by gel electrophoresis and to check the biological functionalities of ...
Modeling of delayed fluorescence from photosystem II and applications in assessment of drought and chemical stresses
(University of Missouri--Columbia, 2009)
Photosynthesis is not only vital for plant growth and survival but also indicative of plant-environment interactions. This research was designed to analyze photoelectron kinetics and its dependence on environmental factors. ...
Ion-selective electrodes for simultaneous real-time analysis for soil macronutrients
(University of Missouri--Columbia, 2006)
Automated sensing of soil macronutrients (i.e., N, P, and K) would allow more efficient mapping of soil nutrient variability for variable-rate nutrient management. This study reports on the development of a sensor array ...
Optical characterization of skeletal muscles
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The optical absorption and reduced scattering coefficients of bulk skeleton muscle were measured by fitting the diffusion model to spatially resolved ...
Effects of oxidative stress and Alzheimer's amyloid-beta peptide on astrocytes
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oxidative stress and deposition of amyloid-[beta] peptide (A[beta]) in brains have been hypothesized as causes of Alzheimer's disease (AD), and research ...
Development of a human immunodeficiency virus (HIV-1) biosensor utilizing liquid core waveguides
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Millions of individuals are diagnosed each year with Human Immunodeficiency Virus Type 1. Each day more individuals are receiving antiretroviral ...
CCVJ's fluorescence lifetime as a viscosity measurement tool and its possible application as a tunable picoseconds reference lifetime standard
(University of Missouri--Columbia, 2007)
9-(2-carboxy-2-cyanovinyl) julolidine (CCVJ, a molecular rotor) was shown to perform as a viscosity sensitive probe. Using steady state spectroscopy, CCVJ was shown to have decreased emission intensity as the environmental ...
Optical stimulation of quantal exocytosis on transparent microchips
(University of Missouri--Columbia, 2007)
Photorelease of caged Ca²⁺ is a uniquely powerful tool to study the dynamics of Ca²⁺-triggered exocytosis from individual cells. Using photolithography and other microfabrication techniques, we have developed transparent ...
Ratiometric techniques to determine fluid viscosity using molecular rotors
(University of Missouri--Columbia, 2007)
Molecular rotors exhibit viscosity-dependent quantum yield, potentially allowing measurements of fluid viscosity in non-mechanical manner. Several diseases are accompanied by blood plasma viscosity changes; therefore, a ...
Development of electrospun synthetic bioabsorbable fibers for a novel bionanocomposite hernia repair material
(University of Missouri--Columbia, 2008)
In order to create a more durable and biocompatible hernia repair mesh, a novel bionanocomposite material based on the crosslinking of bioabsorbable polymer fibers to decellularized porcine diaphragm tissue is proposed. ...
Quantification of cell attachment on different materials as candidate electrodes for measurement of quantal exocytosis
(University of Missouri--Columbia, 2008)
A high throughput lab-on-a-chip device is being developed for single cell capture for the purpose of high time resolution quantal exocytosis measurement with high probability of cell docking. This device makes use of DLC ...