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Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries.
(2011-04-14)
Abstract
Background
Dietary supplementation with tocotrienols has been shown to decrease the risk of coronary artery disease. Tocotrienols are plant-derived forms of vitamin E, which have potent anti-inflammatory, ...
Meeting report: 2nd workshop of the United States culture collection network (May 19-21, 2014, State College, PA, USA)
(2014-12-29)
This report summarizes the activities and outcomes of the second workshop of the US Culture Collection Network, formally an activity of the US National Science Foundation sponsored Research Coordination Network for a ...
Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study
(2014-09-27)
Abstract
Introduction
Prompt treatment of severe sepsis in the Emergency Department reduces deaths, but the role of prehospital ...
RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
(2012-12-21)
Abstract
Background
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence ...
Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos
(2010-01-07)
Abstract
Background
Considerable progress has been made in our understanding of sex determination and dosage compensation mechanisms ...
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
(2010-10-05)
Abstract
Background
The ability to respond to changes in the extra-intracellular environment is prerequisite for cell survival. Cellular responses to the environment include elevating defense systems, such as the ...
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
(2010-12-16)
Abstract
Background
Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated. ...
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
(2010-12-16)
Abstract
Background
Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated. ...
HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-kappaB pathway and can be silenced by gp120-specific siRNA
(2010-12-29)
Abstract
Background
The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine ...
HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-kappaB pathway and can be silenced by gp120-specific siRNA
(2010-12-29)
Abstract
Background
The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine ...
Motivational Interviewing for encouraging quit attempts among unmotivated smokers: Study protocol of a randomized, controlled, efficacy trial.
(2012-06-19)
Abstract
Background
Although the current Clinical Practice Guideline recommend Motivational Interviewing for use with smokers not ready to quit, the strength of evidence for its use is rated ...
Perceptions of neighborhood social environment and drug dependence among incarcerated women and men: a cross-sectional analysis
(2012-09-10)
Abstract
Background
Perception of neighborhood social environment can influence an individual’s susceptibility to drug dependence. However, this has never been examined with a jailed ...
Association of 25-hydroxyvitamin D deficiency with NT-pro BNP levels in patients with acute myocardial infarction: a cross-sectional analysis
(2011-12-15)
Abstract
Background
Nutritional vitamin D deficiency is an emerging risk factor for acute myocardial infarction (AMI) and heart failure. The association of 25-hydroxyvitamin D levels with N-terminal pro B-type natriuretic ...
GAL1-SceI directed site-specific genomic (gsSSG) mutagenesis: a method for precisely targeting point mutations in S. cerevisiae.
(2011-12-05)
Abstract
Background
Precise targeted mutations are defined as targeted mutations that do not require the retention of other genetic changes, such as marker genes, near the mutation site. In the yeast, S. cerevisiae, ...
Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy
(2011-12-14)
Abstract
This study is designed to test the hypothesis that docetaxel [Doc] containing oily core nanocapsules [NCs] could be successfully prepared with a high percentage encapsulation efficiency [EE%] and high drug loading. ...
FEPI-MB: identifying SNPs-disease association using a Markov Blanket-based approach
(2011-11-24)
Abstract
Background
The interactions among genetic factors related to diseases are called epistasis. With the availability of ...
Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor
(2012-06-14)
Abstract
Background: Altered immune function during ageing results in increased production of nitric oxide (NO) and other inflammatory mediators. Recently, we have reported that NO production was inhibited ...
CPP-ZFN: A potential DNA-targeting anti-malarial drug
(2010-09-16)
Abstract
Background
Multidrug-resistant Plasmodium is of major concern today. Effective vaccines or successful applications of RNAi-based strategies for the treatment of malaria are currently unavailable. An unexplored ...
delta-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens
(2011-02-28)
Abstract
Background
Chronic, low-grade inflammation provides a link between normal ageing and the pathogenesis of age-related diseases. A series of in vitro tests confirmed the strong anti-inflammatory activities ...
The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity
(2011-09-27)
Abstract
Background
The fungal pathogen Candida albicans is frequently seen in immune suppressed patients, and resistance to one of the most widely used antifungals, fluconazole (FLC), can evolve rapidly. In recent years ...