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Spectroscopic investigations of dendritic polymers as molecular containers
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Previous research has shown the fluorescent probe phenol blue will associate with the dendritic polymers polypropyleneimine (PPI) and polyamidoamine (PAMAM). The phenol blue...
Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The novel molecular architecture of dendrimers facilitates use in many applications. Using the solvatochromic probe phenol blue, the first direct examination...
Synthesis of silyloxyacrolein for [4+3] cycloaddition and preparation of carbonate closomer
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Followed by Funk's method, I synthesized silyloxyacroleins and used them as dienophiles to react with different dienes in [4+3] cycloaddition reaction. These enals such as 2...
Finite element analysis for the insertion process of the press-fitted total hip arthroplasty
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] There are more than 300,000 total hip arthroplasty (THA) surgeries performed every year in the United States. Press-fitted artificial hip joints are wildly used for relatively...
Variable-temperature [superscript 1]H-NMR and AB initio study of 5-amino-imidazole-4-carboxamide (AICA) : competing paths for amide-H scrambling
(University of Missouri--Columbia, 2008)
5(4)-aminoimidazole-4(5)-carboxamide (AICA and TAICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular. Biotic nucleobase synthesis has been studied ...
Studies on the nucleophilic substitution reactions of a dimeric cyclopentadienone
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Nucleophilic substitution reactions of 3,5-Dibromo-3a,4,7,7a-tetrahydro-4,7-methano-indene-1,8-dione (48) have been studied. Amines, thiols and alcohols have been employed...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Superscript 105]RH has attractive nuclear and chemical properties to be investigated as a nuclide for development of potential radiopharmaceuticals. Complexes of Rh...
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
analogues were synthesized as sigma ligands. Sigma receptors binding assays were conducted for the piperidine analogues. The last chapter is concerned with the opioid receptors, which have three subtypes: mu, delta, and kappa. The [mu]-opioid receptor...
Oxidation & 1, 5-hydride shift of sulfoximine derivatives
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oxidation of N-alkyl and N-aryl sulfoximines and 1,5-hydride shift of S-alkenyl sulfoximines have been studied. Oxidation of N-alkyl sulfoximines using dimethyldioxirane gave...
Advancing Uranium(III) reductive chemistry through hetroleptic metallocene aryloxide ligand frameworks
(University of Missouri--Columbia, 2023)
-4-CH3C6H2 (BHT), with CO2 and CS2 are investigated. For chapter three, the U(III) complex, [(C5Me5)2U(OMes)(THF)], Mes = 2,4,6-Me3C6H2, with Fe(CO)5 forms [{(C5Me5)2(MesO)U}2([mu]2-(OC)2Fe(CO)2)] with the bridging, tetrahedral Fe(CO)4 moiety...
Diverse applications of covalent cross-links in duplex DNA: From anti-cancer drugs to the detection of disease-relevant single nucleotide polymorphisms to the synthesis of well-defined substrates for the study of novel DNA repair processes
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic (Ap) sites are a common form of DNA lesion that occur endogenously 50,000-200,000 per cell per day in mammals. The alkylation of the guanine and adenine residues...
Spatially resolved and bulk zinc analysis in biological samples of patients at different stages of Alzheimer's disease by high resolution inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2008)
One hypothesis that has gained considerable attention in the pathogenesis of Alzheimer's disease (AD) is trace element toxicity, and various elements, including zinc, have become the foci of renewed interest. The first ...
Purification and characterization of A[beta] and probing the interactions between myricetin and A[beta] using various spectroscopic methods
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Worldwide, millions of people suffer from symptoms of memory loss and confusion associated with Alzheimer's disease (AD). Mounting evidence suggests a close relationship between...
Investigating reaction conditions for controlling the self-assembly of metal-seamed pyrogallol[4]arene nanocapsules
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Upon coordination to metal ions, C-alkylpyrogallol[4]arenes (PgCn, where n is the number of carbon atoms in the pendant alkyl chains), can be assembled into spherical metal...
Development of advanced chemometric methods for the analysis of deep-UV resonance Raman spectra of proteins
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ultra violet resonance Raman (UVRR) is a powerful spectroscopic technique for determining the secondary structural content of proteins in solution. However, the analyses of UVRR...
Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroline-5-carboxylate (P5C...
The use of pluripotent stem cells as a model for early human placentation
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Throughout gestation, the placenta plays a critical role in ensuring proper development of the fetus. The placenta functions to exchange nutrients, oxygen, and fetal waste...
Studies of 2,1-benzothiazine, silver-catalyzed rearrangement and 1,5-hydride shift
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Dimethyl sulfoximine was used to synthesize benzothiazines by coupling reaction. When the substrate is dibromodibenzaldehyde, water was added to complete the reaction in meso...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Over the past decades, the Green Chemistry and Sustainability concept has aroused researchers to denounce their traditional ways of thinking regarding chemical processes...
Studies and synthetic methodology of Nampt inhibition
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various cancer cells and to synthesize...