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What are the current treatment and monitoring recommendations for hepatitis C virus (HCV)?
(Family Physicians Inquiries Network, 2001)
. Genotype 1 should be treated with dual therapy for 48 weeks and all other types treated for 24 weeks. Evidence is lacking on the optimum monitoring approach for patients taking dual therapy; consensus recommendations are given in the TABLE 1. Recent...
Counseling or Antidepressants for Treating Depression?
(Family Physicians Inquiries Network, 2005)
, based on randomized controlled trials (RCTs) and systematic reviews] There is limited evidence that antidepressant medications and cognitive behavioral therapy are similarly effective for patients with severe depression [Strength of recommendation: B...
What is the best treatment for chronic constipation in the elderly?
(Family Physicians Inquiries Network, 2007)
There is no one best evidence-based treatment for chronic constipation in the elderly. While the most common first-line treatments are dietary fiber and exercise, the evidence is insufficient to support this approach in the geriatric population...
Is the long-term use of proton pump inhibitors safe?
(Family Physicians Inquiries Network, 2004)
Long-term use of proton pump inhibitors (PPIs) appears safe, resulting in no clinically relevant adverse effects (strength of recommendation: B, based on nonsystematic reviews, cohort studies, or low-quality randomized controlled trials...
Should we recommend universal neonatal hearing screening?
(Family Physicians Inquiries Network, 2005)
Universal neonatal hearing screening leads to both earlier detection and earlier treatment of infants with hearing loss (strength of recommendation [SOR]: A, based on a systematic review). Available evidence suggests early identification...
Do nasal decongestants relieve symptoms?
(Family Physicians Inquiries Network, 2003)
Oral and topical nasal decongestants result in a statistically significant improvement in subjective symptoms of nasal congestion and objective nasal airway resistance in adults' common colds (strength of recommendation [SOR]: A, based on randomized...
Are antibiotics helpful for acute maxillary sinusitis?
(Family Physicians Inquiries Network, 2003)
systematic reviews and randomized controlled trials). Antibiotics can provide symptomatic relief, best demonstrated in patients with bacterial maxillary sinusitis confirmed by computed tomography (CT) or sinus aspiration (SOR: A, based on 1 systematic review...
Is screening for lead poisoning justified?
(Family Physicians Inquiries Network, 2003)
Evidence is insufficient to recommend for or against universal screening of young children for lead poisoning in high- prevalence communities (strength of recommendation [SOR]: C). In low-prevalence communities, evidence is insufficient to recommend...
Do routine eye exams reduce occurrence of blindness from type 2 diabetes?
(Family Physicians Inquiries Network, 2004)
to 12 and 4 months, respectively (strength of recommendation [SOR]: B, based on 1 prospective cohort study). A reliably sensitive screening exam requires mydriatic retinal photography augmented by ophthalmoscopy when photographs are inconclusive (SOR: A...
What is the differential diagnosis of chronic leg edema in primary care?
(Family Physicians Inquiries Network, 2008)
(NSAIDs), and proteinuria (>1 g daily) (strength of recommendation: B, based on a nonconsecutive diagnostic cohort study with good reference standards)....
Which strategies work best to prevent obesity in adults?
(Family Physicians Inquiries Network, 2009)
Regular physical activity decreases long-term weight gain (strength of recommendation [SOR]: B, 2 high-quality, randomized controlled trials [RCTs]). Decreasing fat intake (SOR: B, 1 high-quality systematic review) and increasing fruit and vegetable...
Does a high-fiber diet prevent colon cancer in at-risk patients?
(Family Physicians Inquiries Network, 2003)
]=A, based on consistent randomized clinical trials). Furthermore, epidemiological evidence is inconsistent in demonstrating an association between dietary fiber consumption and the occurrence of colon cancer (SOR=C)....
What are appropriate screening tests for infants and children?
(Family Physicians Inquiries Network, 2006)
There is adequate evidence for screening neonates for hemoglobinopathies, congenital hypothyroidism, phenylketonuria (strength of recommendation [SOR]: A), and cystic fibrosis (SOR: B). Vision screening should be done for those younger than age 5...
Hip Pain in Preschool-Age Children
(Family Physicians Inquiries Network, 2009)
Evidence is lacking on the most common causes of hip pain in children because most data come from cohort studies and include referred patients. Based on these studies, transient synovitis is the most common cause of hip pain in preschool...
Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis?
(Family Physicians Inquiries Network, 2003)
No direct evidence suggests glucosamine or chrondroitin cause regeneration of cartilage in osteoarthritis. Use of glucosamine sulfate in knee osteoarthritis prevents joint space narrowing on radiographs (strength of recommendation [SOR]: B, based...
What predicts a successful smoking cessation attempt?
(Family Physicians Inquiries Network, 2006)
Quit date abstinence (strength of recommendation [SOR]: B, based on low-quality randomized controlled trial [RCT] of healthy subjects) and refraining from tobacco products within the first 2 weeks after an attempt (SOR: A, based on 2 RCTs) predict...
What's the most practical way to rule out adrenal insufficiency?
(Family Physicians Inquiries Network, 2009)
A morning serum cortisol level >13 mcg/dL reliably rules out adrenal insufficiency, and the test is easy and safe to perform. Because of low specificity, patients with a level of ≤13 mcg/dL need further evaluation with the cosyntropin stimulation...
Do statins delay onset or slow progression of Alzheimer's dementia?
(Family Physicians Inquiries Network, 2005)
on preventing or slowing all-cause cognitive decline (strength of recommendation [SOR]: A, based on large RCTs with narrow confidence interval). Specifically, there is insufficient evidence that statins delay the onset or slow the progression of Alzheimer...
What medication best prevents migraine in children?
(Family Physicians Inquiries Network, 2003)
controlled trial, prospective or retrospective cohort studies, or trials with conflicting evidence). Flunarizine and nimodipine have the best evidence of benefit in children; however, availability, cost, and side effects limit their usefulness (SOR: B, based...
Are overweight children more likely to be overweight adults?
(Family Physicians Inquiries Network, 2009)
Overweight at any age in childhood increases the risk for overweight in adulthood. The relative risk (RR) ranges from 1.9 to 10.1 and increases as children get older. Not all overweight children become overweight adults, however (strength...