Search
Now showing items 1-13 of 13
Development of a flexible image-based approach for studying signal transduction in isolated arterioles
(University of Missouri--Columbia, 2007)
Myogenic constriction in arterioles occurs when membrane tension leads to smooth muscle depolarization and voltage-gated calcium channel activation. A barrier to understanding the exact signaling events is the limited ...
The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart
(University of Missouri--Columbia, 2008)
Heart is one of the most important organs of the body and also it is one of the first organs during to the development. The electrical activity of heart is essential for its function. It has been shown that the sodium-calcium ...
Regulation of calcium signaling by p130PH in astrocytes
(University of Missouri--Columbia, 2009)
Ca2+ signaling is a characteristic form of astrocyte excitability, but its role in ischemia is not clearly understood. Our previous study (Ding et al., 2009) demonstrated that astrocytes exhibit enhanced Ca2+ signaling ...
Characterization of membrane viscosity changes with the novel molecular rotor FCVJ
(University of Missouri--Columbia, 2007)
Membrane viscosity can be defined as the "thickness" of a cell membrane. Membrane viscosity conditions are a useful indicator of cell health. Many diseases have been reported to induce changes in afflicted cell membrane ...
Gating of CFTR chloride channels : distinct closed states revealed by the action of AMP-PNP
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The CFTR chloride channel is gated by ATP through an irreversible gating cycle driven by an input of free energy of ATP hydrolysis. The open state of ...
Effects of oxidative stress and Alzheimer's amyloid-beta peptide on astrocytes
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oxidative stress and deposition of amyloid-[beta] peptide (A[beta]) in brains have been hypothesized as causes of Alzheimer's disease (AD), and research ...
Optical glucose nanobiosensor encapsulated in erythrocytes
(University of Missouri--Columbia, 2007)
An implantable glucose biosensor encapsulated in erythrocytes, Red Blood Cells (RBC), will become a method for continuously measuring blood glucose concentration in diabetics. In 2005, the American Diabetes Association ...
Quantification of cell attachment on different materials as candidate electrodes for measurement of quantal exocytosis
(University of Missouri--Columbia, 2008)
A high throughput lab-on-a-chip device is being developed for single cell capture for the purpose of high time resolution quantal exocytosis measurement with high probability of cell docking. This device makes use of DLC ...
Ratiometric techniques to determine fluid viscosity using molecular rotors
(University of Missouri--Columbia, 2007)
Molecular rotors exhibit viscosity-dependent quantum yield, potentially allowing measurements of fluid viscosity in non-mechanical manner. Several diseases are accompanied by blood plasma viscosity changes; therefore, a ...
Natural and synthetic materials for the regeneration of osseous tissue
(University of Missouri--Columbia, 2017)
Bone is a complex tissue with many regulation mechanisms which can be taken advantage of through the release of simple signaling molecules delivered via a biodegradable material like a hydrogel. Hydrogels are water swollen ...
Study of human pupillary light reflex and its potential application in autism
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pupillary light reflex (PLR) can be used as an objective and non-invasive method to evaluate certain brain functions. In this research, we developed ...
CCVJ's fluorescence lifetime as a viscosity measurement tool and its possible application as a tunable picoseconds reference lifetime standard
(University of Missouri--Columbia, 2007)
9-(2-carboxy-2-cyanovinyl) julolidine (CCVJ, a molecular rotor) was shown to perform as a viscosity sensitive probe. Using steady state spectroscopy, CCVJ was shown to have decreased emission intensity as the environmental ...
A fiber-optic confocal scanner for scattering tissue
(University of Missouri--Columbia, 2009)
Confocal microscopy has become an important diagnostic tool in examining scattering tissues. The high resolution of confocal microscopy and its optical sectioning capabilities lend itself as a desirable modality in examining ...