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Phosphinimines as potential technetium environmental sensors
(University of Missouri--Columbia, 2007)
Phosphinimines, R₃P=NSiMe₃, undergo hydrolysis to form the phosphiniminiumcation, R₃P=NH₂+, which forms the ion pair [R₃P=NH₂+][X-] in the presence of an anion.Preliminary studies show that in the presence of TcO₄-, ...
Determination of total selenium and seleno-amino acids in yeast and aquatic organisms by liquid chromatography and inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2007)
The primary goal of this dissertation research was to develop methods for routine speciation analysis of selenium in tissues. A method for total selenium using on-line stable isotope dilution analysis with conventional ...
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family that has two subtypes: sigma1 and sigma2. Sigma1 receptors are involved in several physiological functions such as psychosis and depression. Sigma2 receptors are expressed in ...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Anisotropic organic materials are attracting increasing interesting for their highly electro-optic characteristics. We are especially interested in ...
Organo nickel and platinum chemistry at the edge of corannulene
(University of Missouri--Columbia, 2007)
of �ML[subscript 2]� (M = Ni, Pt) with tetrabromocorannulene (C[subscript 20]H[subscript 6]Br[subscript 4]) and well- isolated by the column chromatography. The corresponding bowl-to-bowl inversion barriers are evaluated by NMR experiments in the range...
Deantiaromatization as a driving force in an electrocyclization of cyclopentadienone and the total synthesis of 1-epi-esco-pseudopteroxazole
(University of Missouri--Columbia, 2007)
Deantiaromatization has been successfully demonstrated as a driving force in an electrocyclization of cyclopentadienones. The reaction was found to be general for a number of substrates and provides a unique way to access ...
Structure and synthesis of four supramolecular structures involving Cu(I) and 4,7-phenanthroline
(University of Missouri--Columbia, 2007)
The design and synthesis of supramolecular species with discrete geometric shapes has been an area of much interest and research in recent years. Three isolated species of square shaped molecules and one infinite network ...
Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Leinamycin is a structurally novel natural product isolated from the Streptomyces with potent antitumor and antibiotic activity. In a thiol rich ...
Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In recent years a great deal of interest has been focused on the exposure to nitrous acid (HNO2), nitric oxide (NO) and other nitrosating species ...
Diels-alder reactions of a cyclopentadienone derivative
(University of Missouri--Columbia, 2007)
An ester derivative of cyclopentadienone, a very reactive species, was generated from methyl-2-bromo-3-oxocyclopent-1-enecarboxylate (96) which dimerized instantaneously and decarbonylated to generate an indanone (97). ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an ...
Probing supramolecular assemblies via fluorescent reporter molecules
(University of Missouri--Columbia, 2007)
Supramolecular, self-assembled nanocapsules have shown the capability to encapsulate organic guests. Since most of the work was done previously in the solid state, the novelty of this research was its focus on probing ...
Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals
(University of Missouri--Columbia, 2007)
Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 ...
pH sensitive fluorescent sensors
(University of Missouri--Columbia, 2007)
Pheochromocytoma is a cancer of the adrenal gland. Pheochromoocytomas produce a variety of catecholamines, including norepinephrine. The result is high blood pressure which is caused by the release of catecholamines into ...
Pertechnetate immobilization with sulfide in aqueous media under anaerobic and aerobic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Technetium-99 (Tc-99) is a high yield radionuclide produced from thermal neutron fission. As a consequence of the development of nuclear weapons over ...