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Effects of pressure and temperature on the yield strength of tantalum and rhenium
(2013)
The effects of pressure and temperature on the yield strength of tantalum and
the effects of pressure on the yield strength of rhenium were investigated using ruby
fluorescence. A new Raman system with a motorized stage ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Synthesis and analysis of siloranes for use as a biomaterial and extended twisted molecular ribbons
(2013)
The development of complex organic molecules with industrial potential requires
meticulous synthetic methodologies coupled with detailed investigations surrounding their
physical properties. This dissertation encompasses ...
Structural and enzymatic characterization of bacterial cell wall enzymes: focus on penicillin-binding proteins
(2013)
The research presented in this dissertation was aimed at understanding several structural and biochemical features underlying the bacterial cell wall biosynthetic process using statistical, biochemical and analytical tools. ...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)
Controlled drug delivery utilizing novel biodegradable and biocompatible pentablock copolymers could be a valuable strategy for the treatment of chronic eye diseases. In attempts to achieve controlled drug release, various ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Chirality directed self-assembly: in situ construction of recyclable and reusable Janus dendrimers
(2021)
. In order to move towards a more sustainable chemistry, optimization of the use of catalysts for better efficiency is essential. To that end, the ideal strategy should be focused on running a series of catalyzed reactions in a single vessel...
Studies of Conjugated Small Molecules, Polymers and Organic-Inorganic Hybrid Materials for Photovoltaic Applications
(2015)
This dissertation focuses on the photophysical properties and device studies of three different types of materials, namely polyoxometalate (POM)-containing organic-inorganic hybrids, near-IR absorbing conjugated polymers and discotic polycyclic...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ...
Practical Applications of Infrared, Raman and Nuclear Magnetic Resonance Spectroscopic Techniques for Qualitative, Quantitative and Structural Analysis of Pharmaceutical Drugs, Cementitious Material and Organic Molecules Containing Phosphorous
(University of Missouri--Kansas City, 2016)
techniques depending on the different types of radiation. This dissertation focuses on implementation of various spectroscopic techniques such as Infrared, Raman and Nuclear Magnetic Resonance (NMR) spectroscopy in order to determine theoretical...
Design, synthesis, characterization and photovoltaic applications of conjugated polymer hybrids containing coordinatively binded semiconducting nanocrystals
(2014-07-17)
Orgainc-inorganic hybrids containing organic conjugated polymers and inorganic semiconducting nanocrystals are fascinating optoelectronic materials which may combine the advantages of both worlds. This dissertation aims ...
Biogeochemistry and inorganic geochemistry as indicators of the paleoenvironment and paleohydrology of the Al-Azraq Basin, Jordan
(2013)
This study investigates the biogeochemical and inorganic geochemical
indicators for past environments and paleohydrology of a high resolution sediment record
from the Al-Azraq Basin, Jordan. The second largest basin in ...
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...
Design and optimization of nanoformulation loaded with HIV microbicides
(2013)
The objective of this dissertation is to design and optimize nanoformulation for microbicides intended for the prevention of HIV/AIDS transmission. In chapters 1 and 2, the aims and the scope of this work are introduced, ...
Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
(2014-08-28)
Tissues such as liver, kidney, brain and intestine expresses membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression ...
Molecular structure determination: solid-state NMR applications
(University of Missouri--Kansas City, 2012-12-14)
Solid-state Nuclear Magnetic Resonance (ssNMR) has become one of the best
techniques to determine molecular structure via inter/intra-molecular interactions.
Unlike the well-known solution state NMR, solid-state NMR ...
Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)
This dissertation is divided into two parts. Part #1 focuses on the development and characterization of closomer based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development and characterization of a...
Photoemission Spectroscopy Studies of New Topological Insulator Materials
(2015-08-04)
As the size of a solid shrinks, the ratio of surface area to bulk volume grows and
surface effects become more important. In a world where technologies advance with the
shrinking size of electronic devices, one phase of ...