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Approaches for unveiling the kinetic mechanisms of voltage gated ion channels in neurons
(University of Missouri--Columbia, 2019)
Ionic currents drive cellular function within all living cells to perform highly specific tasks. For excitable cells, such as muscle and neurons, voltage-gated ion channels have finely tuned kinetics that allow the ...
Hierarchical nonlinear, multivariate, and spatially-dependent time-frequency functional methods
(University of Missouri--Columbia, 2013)
through carefully chosen basis expansions (empirical orthogonal functions) and feature-extraction stochastic search variable selection (SSVS). Properties of the methodology are examined through an extensive simulation study. Finally, we illustrate...
Omputational perspectives of memory storage and gamma oscillation within the amygdala
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Background and motivation: Survival is a key trait seen in all animal species. To survive, it is necessary to have the ability to associate fear ...
Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)
, and as we've seen with extensive HIV-1 studies, can be thrown into disarray through targeted drug design. The implications of this work stand to benefit the study of plant pararetroviruses and could greatly inform the study of HBV RT, which to this day has...
Comparing the impacts of biofuels using survey and non-survey data
(University of Missouri--Columbia, 2010)
This paper utilizes survey data to compare several non-survey methods of modeling the economic impacts of biofuels plants. It examines differences in the input coefficients derived from the survey versus the trade coefficients ...
The log in my eye : awareness, acceptance, and correction of partisan political bias
(University of Missouri--Columbia, 2019)
People are often unaware of or under-estimate their own cognitive biases, suggesting that political bias -- measured by the influence of irrelevant political information on otherwise non-political judgments -- may be ...
Mizzou, volume 102, number 1 (2013 Fall)
(MU Alumni Association, University of Missouri, 2013)
New perspective on the role of conceptus estrogens in conceptus development, maternal recognition, and the establishment of pregnancy in pigs.
(University of Missouri--Columbia, 2018)
The proposed signal for maternal recognition of pregnancy in pigs is estrogen, produced by the elongating conceptus. To understand the role of estrogen in porcine conceptus elongation and pregnancy establishment, a loss ...
Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the ...
Dance-based therapy to decrease fall risk in older persons
(University of Missouri--Columbia, 2010)
persons. This study was an extension of a pilot study conducted in 2008, which has been translated into practice with dance-based therapy offered weekly in a Program of All-inclusive Care for the Elderly (PACE). As demonstrated in the pilot session...
Preclinical evaluation of 177Lu-BBR2 antagonist radiothearpy of prostate cancer
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Castration resistant prostate cancer (CRPC) is the second most common cause of cancer death in the United States. Current treatment protocols offer ...
Development and analysis of ZnO-based semiconductor photodetectors for UV detection
(University of Missouri--Columbia, 2010)
The objective of this thesis is to develop ZnO-based semiconductor photodetectors for UV detection with low dark current, high responsivity, and fast response time. To achieve this objective, an understanding of carrier ...
Investigation of rare alleles in maize using the zea synthetic doubled haploid population
(University of Missouri--Columbia, 2019)
have not been extensively studied due to limited resolution and allelic representation issues. Therefore, a new genetic resource, the Zea Synthetic, was created utilizing both teosinte and maize. The Zea Synthetic is a randomly mated synthetic breeding...
Design and optimization of nanoformulation loaded with HIV microbicides
(2013)
The objective of this dissertation is to design and optimize nanoformulation for microbicides intended for the prevention of HIV/AIDS transmission. In chapters 1 and 2, the aims and the scope of this work are introduced, ...
A role for insulin in the central control of sympathetic nerve activity in humans
(University of Missouri--Columbia, 2010)
Although well recognized for the regulation of peripheral metabolism, an emerging body of literature has begun to also establish a role for insulin in neural-cardiovascular control. In this regard, direct administration ...
Merchants and the medieval mirror
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] My dissertation examines the representation of merchants in late medieval poems inspired by mirrors for princes. The mirror was a genre that had an ...
Molecular genetic analysis of DRO1 genes in soybean
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Under drought conditions, a strong and deep root system provides advantages for exploring and exploiting moisture in deeper soil layers where water is ...
Mizzou, volume 101, number 4 (2013 Summer)
(MU Alumni Association, University of Missouri, 2013)
From unique killers to a jumbo genome - isolation and characterization of phages that infect the plant pathogen, Agrobacterium tumefaciens
(University of Missouri--Columbia, 2019)
cell growth and blocks cell division in a broad range of bacteria including Agrobacterium, Sinorhizobium, and Escherichia strains. Another member of the Podoviridae family, Atu_ph08, carries remnants of a lysogen and shares 60.2% identity...