Browsing School of Medicine (MU) by Thesis Department "Pathobiology Area Program (MU)"
Now showing items 1-11 of 11
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Biomechanical and immunological contributions to osteochondral allograft transplantation outcomes
(University of Missouri--Columbia, 2023)Osteochondral allograft (OCA) transplantation offers a reliable option for treating complex articular injuries in multiple joints, but treatment failure rates remain a concern. Lack of functional integration of OCAs is a ... -
Characterization of novel bat influenza viruses and mammalian orthoreoviruses
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Emerging and reemerging RNA viruses including both segmented and nonsegmented viruses cause significant threats to public and animal health. Segmented RNA viruses such as influenza virus and ... -
Chronic vagotomy induces nTS glial activation, reduced glutamatergic signaling, and blunted cardiorespiratory responses
(University of Missouri--Columbia, 2023)The brainstem nucleus tractus solitarii (nTS) is the first site of integration of viscerosensory information provided by afferents of the vagus nerves. The nTS critically contributes to cardiorespiratory function and ... -
Effects of hip joint orientation and skeletal torsion on human locomotor biomechanics and evolution
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 8/1/2024] Bipedal locomotion is a defining feature of the human lineage. However, the form of bipedality in different hominin taxa and the timing of emergence of a human-like striding bipedal gait have ... -
Emerging and infectious diseases: defending against a dynamic opponent
(University of Missouri--Columbia, 2022)Emerging infectious diseases (EID) pose a growing threat to public health each year. Viruses and bacteria alike are major causes of EIDs and as these pathogens mutate, reemergence occurs, leading to the need for advanced ... -
Environmental variability affects gut microbiota and experimental outcomes in mouse models
(University of Missouri--Columbia, 2023)The gut microbiome of humans and animals is critical to host health. Mice are used to investigate the microbiome and its influences; however, the predictive value of such studies is hindered by cage effects due to coprophagy. ... -
Intervertebral disc degeneration : symptomatic and asymptomatic distinguishers
(University of Missouri--Columbia, 2023)Introduction: It is currently not possible to distinguish symptomatic (S) from asymptomatic (A) intervertebral disc degeneration (IVDD) based on patient factors or the degree of degeneration. Additionally, it is not known ... -
Pass the salt : elucidating the chondroprotective properties of hyperosmolar saline irrigation solutions
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 12/1/2024] Arthroscopy is the most commonly performed orthopaedic surgery procedure. During arthroscopic surgery, a continuous flow of irrigation solution is necessary to distend the joint, remove debris, ... -
Pathobiological analysis of developmental dysplasia of the hip and its progression to osteoarthritis
(University of Missouri--Columbia, 2022)Developmental dysplasia of the hip (DDH) is recognized as one of the leading causes of early-onset hip osteoarthritis and a primary reason for undergoing total hip arthroplasty prior to 50 years of age. Even with an increase ... -
Patient adherence to orthopaedic treatment plans : toward patient-centered definitions, measurement, and management
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Patient adherence to prescribed management protocols is associated with improved function, higher patient satisfaction, and lower complication rates following orthopaedic treatments. While adherence ... -
The role of RECK in the pathogenesis of nonalcoholic steatohepatitis
(University of Missouri--Columbia, 2022)Reversion-inducing cysteine-rich protein with Kazal motifs, or RECK, is a cell surface-anchored glycoprotein and a critical regulator of the extracellular matrix (ECM). It has been examined extensively as an anti-metastatic ...