The University of Missouri School of Medicine has improved health, education and research in Missouri for more than 160 years. MU physicians treat patients from every county in the state, and MU is a primary provider of training for all physicians in Missouri. The School of Medicine's more than 650 faculty physicians and scientists educate approximately 1,000 medical students, residents, fellows and other students seeking advanced degrees. Their research is focused on potentially lifesaving discoveries that address the most prevalent health problems.

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  • Attenuation of rapid onset vasodilation with advanced age : roles of adrenergic and endothelial signaling 

    Sinkler, Shenghua Yuan (University of Missouri--Columbia, 2016)
    Rapid onset vasodilation (ROV) occurs immediately in response to skeletal muscle contraction and initiates a prompt increase in blood flow and oxygen delivery that facilitate the transition to exercise. Muscle blood flow ...
  • Discovery and characterization of regulatory mechanisms affecting the heteromeric acetyl-coenzyme a carboxylase in Arabidopsis 

    Salie, Matthew Jacob (University of Missouri--Columbia, 2016)
    Fatty acid biosynthesis (FAS) is an essential metabolic pathway used by all organisms to generate fatty acids. A staple component of this pathway is the enzyme acetyl-CoA carboxylase (ACCase), which catalyzes the committed ...
  • Large-scale analysis, management, and retrieval of biological and medical images 

    Han, Jing (University of Missouri--Columbia, 2016)
    Biomedical image data have been growing quickly in volume, speed, and complexity, and there is an increasing reliance on the analysis of these data. Biomedical scientists are in need of efficient and accurate analyses of ...
  • Ribozymes and aptamers in the RNA world, and in synthetic biology 

    Poudyal, Raghav Raj (University of Missouri--Columbia, 2016)
    The RNA world hypothesis postulates that Ribonucleic Acids (RNA) may have provided functions of catalysis and genetic information storage during the origin of life on earth. An RNA based life is hypothesized to have undergone ...
  • Advances in aptamer evolution and engineering 

    Alam, Khalid Kamal (University of Missouri--Columbia, 2016)
    Aptamers are single-stranded nucleic acids that fold into unique three-dimensional shapes that allow them to bind with high affinity and specificity to targets of interest. They are selected through the process of in vitro ...
  • MUtation, 2015 

    University of Missouri--Columbia. School of Medicine; University of Missouri--Columbia. School of Nursing (University of Missouri--Columbia, 2015)
  • MUtation, 2016 

    University of Missouri--Columbia. School of Medicine; University of Missouri--Columbia. School of Nursing (University of Missouri--Columbia, 2016)
  • I've got a feeling : Gestalt versus Wells for ruling out pulmonary embolus 

    Shelesky, Gretchen; Jarrett, Jennie B. (2017-04)
    Bottom line: Using Gestalt, or clinical opinion, is a good first step in assessing an outpatient with symptoms possibly consistent with PE. However, a Well's score was as reliable as Gestalt when used with a d-dimer, ...
  • In patients with osteoporosis, should subclinical hyperthyroidism be treated? 

    Adam, Patricia; Tsvilina, Alexandra (Family Physicians Inquiries Network, 2017-04)
    In patients with osteoporosis, should subclinical hyperthyroidism be treated? Evidence-based answer: Subclinical hyperthyroidism with thyroid-secreting hormone (TSH) [less than or equal to] 0.45 mIU/L is associated with ...
  • Melatonin : it ain't just for sleep anymore 

    Langner, Shannon (Family Physicians Inquiries Network, 2017-04)
    Bottom line: Melatonin is an option for migraine prophylaxis, as it appears as effective as amitriptyline for migraine prevention with fewer adverse effects.
  • A shot in the arm for renal colic : diclofenac feels the best 

    Maurer, Douglas M. (Family Physicians Inquiries Network, 2017-04)
    Bottom line: IM diclofenac is more effective than IV morphine or IV paracetamol at providing short-term pain relief (50 percent reduction in pain within 30 minutes of administration) in patients with symptoms of renal ...
  • What is the differential diagnosis for an incidentally discovered adrenal mass? 

    Hobart, Keeley; Ireland, A. Jade; Haynes, Jamie (Family Physicians Inquiries Network, 2017-04)
    What is the differential diagnosis for an incidentally discovered adrenal mass? Evidence-based answer: In patients with incidentally discovered adrenal masses on imaging and no history of malignancy or signs and symptoms ...
  • What is the effect of electronic health records on malpractice claims? 

    Kirsch, Caroline; Melville, Brian Tyler (2017-04)
    What is the effect of electronic health records on malpractice claims? Evidence-based answer: The use of electronic health records (EHRs) does not appear to effect the frequency of malpractice claims made or the frequency ...
  • What treatments are effective for relieving blepharospasm (eyelid twitching)? 

    O'Dowd, Stacy; San Juan, Maria (Family Physicians Inquiries Network, 2017-04)
    What treatments are effective for relieving blepharospasm (eyelid twitching)? Evidence-based answer: Botulinum neurotoxin type A (BoNT-A) is effective in up to 90 percent of patients with primary blepharospasm. IncobotulinumtoxinA ...
  • Fluticasone plus salmeterol in persistent stable asthma likely safe 

    Farrah, Roberta; Jarrett, Jennie B. (Family Physicians Inquiries Network, 2017-04)
    Bottom line: Clinicians have additional assurance of safety and efficacy when following current treatment guidelines to use long-acting beta-agonists in combination with inhaled glucocorticoids as recommended. It is unclear ...
  • What are the health risks of using insulin in patients with type 2 diabetes? 

    Kiani, Sarah; Hanif, Mohammad Yusuf; Somma, Lorenzo; Al Achkar, Morhaf (Family Physicians Inquiries Network, 2017-04)
    What are the health risks of using insulin in patients with type 2 diabetes? Evidence-based answer: Despite its effectiveness in improving blood sugar control, high-intensity insulin use is associated with more episodes ...
  • In low-risk pregnancies, is maternal morbidity increased for births occurring in birthing centers compared with hospital births? 

    Guard, Esther; Mercado, Michael (Family Physicians Inquiries Network, 2017-04)
    In low-risk pregnancies, is maternal morbidity increased for births occurring in birthing centers compared with hospital births? Evidence-based answer: The maternal morbidity rates in birthing centers are comparable to ...
  • Do mineral supplements decrease the efficacy of quinolone antibiotics? 

    Walker, William R.; Tyler, Carl (Family Physicians Inquiries Network, 2017-04)
    Do mineral supplements decrease the efficacy of quinolone antibiotics? Bottom line: Mineral supplements and antacids containing the metal cations of iron, zinc, calcium, and aluminum appear to significantly lessen the ...
  • Do mineral supplements decrease the efficacy of quinolone antibiotics? 

    Walker, William R.; Tyler, Carl (Family Physicians Inquiries Network, 2017-04)
    Do mineral supplements decrease the efficacy of quinolone antibiotics? Bottom line: Mineral supplements and antacids containing the metal cations of iron, zinc, calcium, and aluminum appear to significantly lessen the ...
  • What is the effect of electronic health records on malpractice claims? 

    Kirsch, Caroline; Melville, Brian Tyler (Family Physicians Inquiries Network, 2017-04)
    What is the effect of electronic health records on malpractice claims? Evidence-based answer: The use of electronic health records (EHRs) does not appear to effect the frequency of malpractice claims made or the frequency ...

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