The University of Missouri School of Medicine has improved health, education and research in Missouri for more than 160 years. MU physicians treat patients from every county in the state, and MU is a primary provider of training for all physicians in Missouri. The School of Medicine's more than 650 faculty physicians and scientists educate approximately 1,000 medical students, residents, fellows and other students seeking advanced degrees. Their research is focused on potentially lifesaving discoveries that address the most prevalent health problems.

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  • Yeast mutants containing elevated methionine 

    Tarka, Eugene F. (University of Missouri--Columbia, 1983)
    Yeasts are deficient in methionine which restricts the nutritive value of the protein. The objective of this research was to produce a methionine-rich mutant. Mutants of Candida tropical is ATCC 1369, Candida tropica!is ...
  • Synergistic inactivation of Escherichia coli and phage T7 by near-ultraviolet radiation and hydrogen peroxide 

    Hartman, Philip (University of Missouri--Columbia, 1979)
    A non-1ethal concentration of H2O2 enhances NUV inactivation of Escherichia coli and its phages. Three distinct types of synergistic interaction were identified. Conditions were established which allowed the specific ...
  • L-tryptophan photoproduct : effect on DNA replication and DNA repair in Escherichia coli 

    Yoakum, George H. (University of Missouri--Columbia, 1974)
    "This study was stimulated by two important discoveries. The first of these came to a focus when it was observed that recombinationless (rec) mutants of bacteria were readily killed by near-UV irradiation. Recognition of ...
  • The role of serum-glucocorticoid-regulated kinase (SGK1) in arterial reactivity 

    Nahar, Lutfun (University of Missouri--Columbia, 2023)
    [EMBARGOED UNTIL 8/1/2024] Objective: In the vascular system, aldosterone exerts several actions via genomic and non-genomic pathways through MR receptor-dependent/independent mechanisms. Aldosterone exerts its effect by ...
  • Effects of hip joint orientation and skeletal torsion on human locomotor biomechanics and evolution 

    Lawrence, Austin B. (University of Missouri--Columbia, 2023)
    [EMBARGOED UNTIL 8/1/2024] Bipedal locomotion is a defining feature of the human lineage. However, the form of bipedality in different hominin taxa and the timing of emergence of a human-like striding bipedal gait have ...
  • Intervertebral disc degeneration : symptomatic and asymptomatic distinguishers 

    Kramer, Jacob Sidney (University of Missouri--Columbia, 2023)
    Introduction: It is currently not possible to distinguish symptomatic (S) from asymptomatic (A) intervertebral disc degeneration (IVDD) based on patient factors or the degree of degeneration. Additionally, it is not known ...
  • Should RAAS blockade therapy be continued in patients with advanced renal disease? 

    Pham, Kim; Beyer, Carli; Guthmann, Rick (Family Physicians Inquiries Network, 2023-04)
    Q: Should RAAS blockade therapy be continued in patients with advanced renal disease? Evidence-based answer: PROBABLY. Renin-angiotensinaldosterone system (RAAS) blockade therapy should be continued in most patients with ...
  • Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? 

    Dresang, Lee; Vellardita, Lia; Guthmann, Rick (Family Physicians Inquiries Network, 2023-03)
    Q: Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? Evidence-based answer:Possibly. Elevated BMI is associated with an increased risk for stillbirth (strength of recommendation [SOR], B; ...
  • Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? 

    Reddy, Vinay; Allison, James; Mounsey, Anne; Guthmann, Rick (Family Physicians Inquiries Network, 2023-06)
    Q: Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? Evidence-based answer: YES. In patients with known cardiovascular disease (CVD), ezetimibe with a statin decreases major adverse ...
  • Is low-dose naltrexone effective in chronic pain management? 

    Radi, Roxanne; Huang, Harriet; Rivera, Jason; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-09)
    Q: Is low-dose naltrexone effective in chronic pain management? Evidence-based answer: YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety ...
  • Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? 

    Wen, Frances K.; Bigelow, Simone; Crosby, Kimberly; Reeder, Raye; Hoberecht, Toni; Moreau, Emrys; Guthmann, Rick (Family Physicians Inquiries Network, 2023-07)
    Q: Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? Evidence-based answer: NO. In adults with insulin-treated type 2 diabetes (T2D), continuous glucose monitoring (CGM) and flash ...
  • Does regular walking improve lipid levels in adults? 

    Hatchell, Kayla; Chin, Emily; Vukelic, Brian; Fortenberry, Katherine; Ose, Dominick; Taylor, Eliza; Goossen, Rachel; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: Minimally. Regular moderateintensity walking for a period of 4 or more weeks minimally decreased total cholesterol (TC) and low-density lipoprotein (LDL) levels by about 7 mg/dL in women with ...
  • Does physical exercise reduce dementia-associated agitation? 

    Jabbour, Katarzyna; Wilson, Lynn M.; Mathieu, Susan S.; Keister, Drew; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: not consistently. Physical exercise demonstrates inconsistent benefit for neuropsychiatric symptoms, including agitation, in patients with dementia (strength of recommendation: b, inconsistent ...
  • Does hormone replacement therapy prevent cognitive decline in postmenopausal women? 

    Gates, Madeline; Beagle, Melissa; Bull, Lauren; Radi, Roxanne; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-05)
    Q: Evidence-based answer: NO. Hormone replacement therapy (HRT) does not prevent cognitive decline in postmenopausal women—and in fact, it may slightly increase risk (strength of recommendation, A; systematic review, ...
  • How does gender-affirming hormone therapy affect QOL in transgender patients? 

    Wilhelm, Sarah; Kelsberg, Gary; Safranek, Sarah; Guthmann, Rick (Family Physicians Inquiries Network, 2022-12)
    Q: How does gender-affirming hormone therapy affect QOL in transgender patients? Evidence-based answer: There are modest effects on depression but not anxiety. Gender-affirming hormone therapy (GAHT) is associated with ...
  • How accurate is transcutaneous bilirubin testing in newborns with darker skin tones? 

    Boden, Brandi; Buescher, Brittany; Kim, Amanda; Neher, Jon O.; Safranek, Sarah; Guthmann, Rick (Family Physicians Inquiries Network, 2022-11)
    Q: How accurate is transcutaneous bilirubin testing in newborns with darker skin tones? Evidence-based answer: Fairly accurate. Photometric transcutaneous bilirubin (TcB) testing may overestimate total serum bilirubin (TSB) ...
  • EC-SGK1 and EnNaC mediate vascular stiffening 

    Zhang, Liping (University of Missouri--Columbia, 2023)
    [EMBARGOED UNTIL 5/1/2024] Vascular stiffening is an independent predictor of cardiovascular diseases, the leading cause of death worldwide. High dietary salt intake has been shown to increase vascular stiffness in humans, ...
  • Characterization of novel bat influenza viruses and mammalian orthoreoviruses 

    Wang, Liping (University of Missouri--Columbia, 2023)
    [EMBARGOED UNTIL 5/1/2024] Emerging and reemerging RNA viruses including both segmented and nonsegmented viruses cause significant threats to public and animal health. Segmented RNA viruses such as influenza virus and ...
  • Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR 

    Turan, Ali (University of Missouri--Columbia, 2023)
    [EMBARGOED UNTIL 5/1/2024] The main aim of this dissertation was to display novel immunological ligands, Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory ...
  • The multiple roles of FzlA during cell division and stress responses in Agrobacterium tumefaciens 

    Santiago-Collazo, Gustavo (University of Missouri--Columbia, 2023)
    [EMBARGOED UNTIL 5/1/2024] Disruption of the complex and dynamic process of bacterial cell division results in cellular changes to protect the cells from lysis. In the plant pathogen Agrobacterium tumefaciens, absence of ...

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