Browsing Theses and Dissertations (MU) by Thesis Advisor "Daniels, Mark A."
Now showing items 1-4 of 4
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Establishing the posh scaffold as a novel therapeutic target for treatment of B cell leukemia
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] More than 60,000 new cases of leukemia will be diagnosed in the U.S. this year. B cells comprise 10 [percent] of acute lymphoblastic leukemias ... -
Proposed characterization of POSH function in human T-cell Acute Lymphoblastic Leukemia
(University of Missouri--Columbia, 2023)T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive malignancy that is characterized by leukemic T-cells that can express reduced T-cell markers (such as CD5, CD4, or CD8) reflecting their transformation from an ... -
The roles of ERK pathway localization and the regulation of [beta]-catenin/Bcl-XL kinetic in thymic selection
(University of Missouri--Columbia, 2011)Thymocytes undergo a process of development that serves to favor the differentiation of T-cells bearing self-MHC (major histo-compatibility complex) restricted T-cell receptors (TCR). Signaling through the TCR is crucial ... -
The scaffold protein POSH regulates T lymphocyte function
(University of Missouri--Columbia, 2015)T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, ...