Browsing Theses (MU) by Thesis Department "Medical Pharmacology and Physiology (MU)"
Now showing items 1-20 of 21
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Chlorinated lipid induce inflammatory responses in the microcirculation
(University of Missouri--Columbia, 2017)Previous studies from our research group have shown that chlorinated lipid, generated from the neutrophil-myeloperoxidase (MPO) system, are elevated in a rat sepsis model as well as in plasma of septic patients. Other work ... -
The contribution of titin to striated muscle shortening
(University of Missouri--Columbia, 2008)Striated muscle shortens under various loads (i.e., performs work), which allows movement of the skeleton and pumping of blood throughout the circulatory system. The amount of work that a muscle can do is determined by the ... -
The control of blood flow in skeletal muscle arterioles
(University of Missouri--Columbia, 2010)Skeletal muscle arterioles dilate in response to application of acetylcholine (ACh), eliciting a conducted vasodilation (CVD) that travels along unbranched segments without decrement. CVD is known to entail cell-to-cell ... -
Dystrophic cardiomyopathy: the role of myofilaments
(University of Missouri--Columbia, 2022)Dystrophic cardiomyopathy is the consequence of diseases that affect the protein dystrophin. Dystrophin forms part of the dystrophin glycoprotein complex and is postulated to act as a membrane stabilizer, protecting the ... -
The effect of lead on Renal cell carcinoma progression
(University of Missouri--Columbia, 2023)Renal cell carcinoma (RCC) incidence has been steadily increasing over the past few decades, and has become the ninth most common cancer in the United States. It has the highest mortality rate of the genitourinary cancers, ... -
The effect of troponin I phosphorylation on the steepness of the Frank-Starling relationship
(University of Missouri--Columbia, 2013)Heart failure begins with a reduction in the contractile strength of the cardiac myocytes (systolic dysfunction.) Cardiac myofibrils compensate via sympathetic activation to maintain adequate cardiac output. Beta-adrenergic ... -
Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
(University of Missouri--Columbia, 2022)Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy that is caused by a mutation in the dystrophin gene which is located on the X chromosome. DMD affect 1 in 3,600 males at birth. Due to recent ... -
Endothelial phenotype differs by both sex and vessel function
(University of Missouri--Columbia, 2017)Endothelial cells (the cells that line our blood vessels) were once thought to be an inert cellophane-like wrapper separating flowing blood from tissue. However, as our understanding of the human body has progressed, we ... -
Expression of adiponectin receptors by vascular smooth muscle cells
(University of Missouri--Columbia, 2009)Adiponectin (APN) is a 30-kDA insulin-sensitizing protein with strong effects on the vasculature. It binds three receptors: AdipoR1, AdipoR2, and T-cadherin. APN and AdipoRs are well-studied in the vascular endothelium, ... -
Functional differences between pericytes and vascular smooth muscle cells during vascular morphogenesis
(University of Missouri--Columbia, 2011)During vascular morphogenic events, mural cells are recruited to developing endothelial tubes to aid in stabilization and maturation of the new vessels. There are two known types of mural cells, pericytes and vascular ... -
Hypochlorous acid stimulates heme oxygenase-1 gene expression in human endothelial cells
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] In the present study, we tested the hypothesis that Hypochlorous acid (HOCl) regulates the expression of the cytoprotective protein heme oxygenase-1 ... -
Metabolic and autonomic nervous system effects of bariatric surgery
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Despite avid attempts, non-surgical methods such as diet aids, behavioral modification and exercise are typically unsuccessful in achieving long term ... -
Myofibrillar regulatory mechanisms of stretch activation in mammalian striated muscle
(University of Missouri--Columbia, 2017)Stretch activation is described as a delayed increase in force after an imposed stretch. This process is essential in the flight muscles of many insects and is also observed, to some degree, in mammalian striated muscles. ... -
Preload-induced changes in systolic and diastolic performance in the aged and young murine heart
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The aged heart exhibits modifications limiting cardiac performance. The purpose of this study was to test the hypothesis that aged hearts exhibit ... -
Receptor for advanced glycation end-products blockade improves endothelial dependent vascular function in atherosclerotic mice
(University of Missouri--Columbia, 2012)Atherosclerosis is a progressive inflammatory disease that is present in large vessels in the body. We hypothesized that either adiponectin treatment or soluble Receptor for Advanced Glycation Products (sRAGE) treatment ... -
The role of perivascular adipose tissue and infiltrating macrophages in vascular dysfunction with inflammatory bowel disease
(University of Missouri--Columbia, 2022)Historically, adipose tissue (AT) throughout the body has been categorized as either brown adipose tissue (BAT) or white adipose tissue (WAT). These categories are determined by color, physical characteristics, and ... -
Role of plasminogen activator inhibitor-1 in the regulation of mitochondrial function in vascular smooth muscle cells
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor produced by vascular smooth muscle cells (VSMCs) and other cells, triggers metabolic dysfunction and cell senescence in ... -
The role of serum-glucocorticoid-regulated kinase (SGK1) in arterial reactivity
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 8/1/2024] Objective: In the vascular system, aldosterone exerts several actions via genomic and non-genomic pathways through MR receptor-dependent/independent mechanisms. Aldosterone exerts its effect by ... -
Sex differences in cardiac structure and function of Zucker diabetic fatty male and female rats
(University of Missouri--Columbia, 2016)Cardiovascular disease (CVD) is the leading cause of death for American adults, and diabetes mellitus (DM) is an independent risk factor for CVD. Diabetic women, both pre- and postmenopausal, have a greater risk for CVD ... -
The transient receptor potential vanilloid 4 ion channel and calcium homeostasis in cardiomyocytes of aged mice
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Aging and cardiovascular disease are critically linked and have now become a growing concern for the healthcare community. Unfortunately, medicine ...