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dc.contributor.advisorJen, Philip H.-S.en
dc.contributor.authorWu, Chung-Hsin, 1965-en_US
dc.date.issued2006eng
dc.date.submitted2006 Fallen
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionTitle from title screen of research.pdf file (viewed on August 9, 2007)en_US
dc.descriptionVita.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2006.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Neuroscience.en_US
dc.description.abstractSound duration is an important acoustic parameter that contributes to the distinct spectral and temporal attributes of individual biological sounds and is therefore important for sound recognition in human speech, animal communication and bat echolocation. The main objective of this thesis is to examine the duration selectivity of neurons in the central nucleus of the midbrain inferior colliculus (IC) using bats as the mammalian model system under stimulation conditions of single pulses, temporally patterned pulse trains and pulse-echo (P-E) pairs. This thesis also studies the role of GABAergic inhibition in shaping the duration selectivity of IC neurons using iontophoretic application of GABA or bicuculline, which is an antagonist for GABAA receptors. The data obtained from these studies show the following. (1) Neurons at upper IC have sharper duration selectivity than neurons in the deeper IC. (2) GABAergic inhibition contributes to sharpening of duration selectivity of IC neurons to sound pulses in rapid sequences, pulse repetition rate (PRR) of pulse trains, and shortening of pulse duration and P-E gap. (3) The effect of bicuculline application on duration selectivity is more pronounced at high than at low PRR while the opposite is true during GABA application.en_US
dc.identifier.merlin.b59290316en_US
dc.identifier.oclc163585619en_US
dc.identifier.otherWuC-121306-D6162en_US
dc.identifier.urihttp://hdl.handle.net/10355/4369
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2006 Freely available dissertations (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2006 Dissertations
dc.subject.lcshMesencephalonen_US
dc.subject.lcshInferior colliculusen_US
dc.subject.lcshSound production by animalsen_US
dc.subject.lcshBat soundsen_US
dc.subject.lcshGABA -- Antagonistsen_US
dc.titleSound duration selectivity in bat midbrain inferior colliculusen_US
dc.typeThesisen_US
thesis.degree.disciplineNeuroscienceen_US
thesis.degree.disciplineNeuroscienceeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePh. D.en_US


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