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dc.contributor.advisorJen, Philip H.-S.eng
dc.contributor.authorWu, Chung-Hsin, 1965-eng
dc.date.issued2006eng
dc.date.submitted2006 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on August 9, 2007)eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (Ph. D.) University of Missouri-Columbia 2006.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Neuroscience.eng
dc.description.abstractSound duration is an important acoustic parameter that contributes to the distinct spectral and temporal attributes of individual biological sounds and is therefore important for sound recognition in human speech, animal communication and bat echolocation. The main objective of this thesis is to examine the duration selectivity of neurons in the central nucleus of the midbrain inferior colliculus (IC) using bats as the mammalian model system under stimulation conditions of single pulses, temporally patterned pulse trains and pulse-echo (P-E) pairs. This thesis also studies the role of GABAergic inhibition in shaping the duration selectivity of IC neurons using iontophoretic application of GABA or bicuculline, which is an antagonist for GABAA receptors. The data obtained from these studies show the following. (1) Neurons at upper IC have sharper duration selectivity than neurons in the deeper IC. (2) GABAergic inhibition contributes to sharpening of duration selectivity of IC neurons to sound pulses in rapid sequences, pulse repetition rate (PRR) of pulse trains, and shortening of pulse duration and P-E gap. (3) The effect of bicuculline application on duration selectivity is more pronounced at high than at low PRR while the opposite is true during GABA application.eng
dc.identifier.merlin.b59290316eng
dc.identifier.oclc163585619eng
dc.identifier.otherWuC-121306-D6162eng
dc.identifier.urihttp://hdl.handle.net/10355/4369eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations.eng
dc.subject.lcshMesencephaloneng
dc.subject.lcshInferior colliculuseng
dc.subject.lcshSound production by animalseng
dc.subject.lcshBat soundseng
dc.subject.lcshGABA -- Antagonistseng
dc.titleSound duration selectivity in bat midbrain inferior colliculuseng
dc.typeThesiseng
thesis.degree.disciplineNeuroscience (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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