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Functional study of Kcv potassium channel through manipultion [sic] of individual subunits
(University of Missouri--Columbia, 2010)
Potassium channels make up a ubiquitous, physiologically essential class of integral membrane proteins. Many K+ channels contain four identical symmetrically associated subunits. To explore the role of an individual subunit ...
Manure management using precision agriculture
(University of Missouri--Columbia, 2010)
The overall purpose of this project was to develop and implement a manure application record system that was solely based on Global Positioning Systems (GPS). This system will have the ability to provide steering and ...
Study of human pupillary light reflex and its potential application in autism
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pupillary light reflex (PLR) can be used as an objective and non-invasive method to evaluate certain brain functions. In this research, we developed ...
Amyloid- [beta] peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A₂
(University of Missouri--Columbia, 2010)
Oligomeric amyloid-[beta] peptide (A[beta]) is known to induce cytotoxic effects and damage cell functions in Alzheimer's disease. However, mechanisms underlying the effects of A[beta] on cell membranes have yet to be fully ...
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
(University of Missouri--Columbia, 2007)
In order to produce a more versatile, adaptable, and effective method for detection of biological analytes, a self-contained and robust fluorescent optical biosensor architecture utilizing fluorescence resonance energy ...
Photoacoustic discrimination of viable and thermally coagulated blood for burn injury imaging
(University of Missouri--Columbia, 2007)
Early and accurate determination of burn depth is crucial to monitoring and treatment of the burn wound. One such treatment, surgical excision and grafting, involves removal of necrotic tissue from the wound and replacing ...
Characterization of membrane viscosity changes with the novel molecular rotor FCVJ
(University of Missouri--Columbia, 2007)
Membrane viscosity can be defined as the "thickness" of a cell membrane. Membrane viscosity conditions are a useful indicator of cell health. Many diseases have been reported to induce changes in afflicted cell membrane ...
Development of high-resolution optical tomography with a larger-size projection acquisition
(University of Missouri--Columbia, 2007)
In the industrial countries, the mortality from arteriosclerosis and cardiovascular diseases has been decreased, but they remain the most common circulatory disease. Recently, new tissue engineering technologies such as ...
Modeling of phototransduction in vision systems
(University of Missouri--Columbia, 2007)
To improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics ...
Development of a flexible image-based approach for studying signal transduction in isolated arterioles
(University of Missouri--Columbia, 2007)
Myogenic constriction in arterioles occurs when membrane tension leads to smooth muscle depolarization and voltage-gated calcium channel activation. A barrier to understanding the exact signaling events is the limited ...
Regulation of calcium signaling by p130PH in astrocytes
(University of Missouri--Columbia, 2009)
Ca2+ signaling is a characteristic form of astrocyte excitability, but its role in ischemia is not clearly understood. Our previous study (Ding et al., 2009) demonstrated that astrocytes exhibit enhanced Ca2+ signaling ...
Propagation of polarized light in skeletal muscle
(University of Missouri--Columbia, 2009)
Skeletal muscle is a very important tissue in animals and humans. Optical polarization imaging is a non-invasive method to study biological tissues and provides unique polarization contrast. An imaging system was developed ...
Molecularly imprinted polymer labeled with quantum dots for detection of nitroaromatic explosives
(University of Missouri--Columbia, 2010)
A sensing device for explosive compounds is a fundamental step towards the capability to detect the presence of landmines, improvised explosive devices (IEDs), and other unexploded ordinance. To detect high explosive ...
Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development
(University of Missouri--Columbia, 2010)
For several decades, optical ring resonators have played an important role in the field of telecommunications. Within only the past decade however, ring resonators have been applied for the purposes of biological and ...
Applications of gel electrophoresis in quantum dot conjugates' separation and purification
(University of Missouri--Columbia, 2009)
The objectives of this study were to build Quantum dot (QD) crosslinker complexes for antibody conjugation usage, to purify QD crosslinker complexes by gel electrophoresis and to check the biological functionalities of ...
Geographic information systems used for precision agriculture : knowledge and use by agriculture students at the University of Missouri (MU)
(University of Missouri--Columbia, 2010)
The use of GIS in PA technology helps manage the information intensive environment in production agriculture by intertwining site-specific (within field) management with computer software modeling for analyses and ...
Assessing the biocompatibility of different sizes and concentrations of gold nanoparticles conjugated to decellularized tissue scaffolds
(University of Missouri--Columbia, 2016)
Gold nanoparticles conjugated to decellularized scaffolds have been studied previously within the fields of tissue engineering and biomaterials. They hold much potential for applications in soft tissue repair and improved ...
Knee contact force prediction during a step-up task using a subject specific musculoskeletal model with anatomical knee
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Better understanding of knee mechanics can aid in injury prevention and rehabilitation. Multi-body computational models can be used to better understand ...
Development of a composite acellular tissue graft for musculoskeletal tissue engineering
(University of Missouri--Columbia, 2015)
A composite acellular tissue graft comprised of decellularized tendon conjugated with nanomaterials has been developed for musculoskeletal tissue engineering applications. The focus of this dissertation is on the development ...
Imaging fiber orientation in articular cartilage using optical polarization tractography
(University of Missouri--Columbia, 2016)
Articular cartilage plays a vital role in providing a low-friction surface between the bones of joints. This mechanical function is highly related to the special collagen organization in cartilage, especially in the ...